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To date a number of studies have shown that receptive field shapes of early sensory neurons can be reproduced by optimizing coding efficiency of natural stimulus ensembles. A still unresolved question is whether the efficient coding…

神经元与认知 · 定量生物学 2014-03-18 Wiktor Mlynarski

The human brain encodes stimuli from the environment into representations that form a sensory perception of the world. Despite recent advances in understanding visual and auditory perception, olfactory perception remains an under-explored…

机器学习 · 计算机科学 2024-11-06 Farzaneh Taleb , Miguel Vasco , Antônio H. Ribeiro , Mårten Björkman , Danica Kragic

Cells continuously sense their surroundings to detect modifications and generate responses. Very often changes in extracellular concentrations initiate signaling cascades that eventually result in changes in gene expression. Increasing…

细胞行为 · 定量生物学 2024-08-27 Alan Givré , Alejandro Colman-Lerner , Silvina Ponce Dawson

Developments in reinforcement learning (RL) have allowed algorithms to achieve impressive performance in highly complex, but largely static problems. In contrast, biological learning seems to value efficiency of adaptation to a…

人工智能 · 计算机科学 2022-05-20 Eric Chalmers , Artur Luczak

To perform recognition, molecules must locate and specifically bind their targets within a noisy biochemical environment with many look-alikes. Molecular recognition processes, especially the induced-fit mechanism, are known to involve…

生物大分子 · 定量生物学 2010-07-27 Yonatan Savir , Tsvi Tlusty

We present a generalized theoretical framework for olfactory representation and plasticity, using the theory of smooth manifolds and sheaves to depict categorical odor learning via distributed neural computation. Beginning with the space of…

神经元与认知 · 定量生物学 2023-10-13 Jack A. Cook , Thomas A. Cleland

This paper considers neural representation through the lens of active inference, a normative framework for understanding brain function. It delves into how living organisms employ generative models to minimize the discrepancy between…

The application of deep learning techniques on aroma-chemicals has resulted in models more accurate than human experts at predicting olfactory qualities. However, public research in this domain has been limited to predicting the qualities…

机器学习 · 计算机科学 2024-06-06 Laura Sisson , Aryan Amit Barsainyan , Mrityunjay Sharma , Ritesh Kumar

Communication signals often comprise an array of colors, lines, spots, notes or odors that are arranged in complex patterns, melodies or blends. Receiver perception is assumed to influence preference and thus the evolution of signal design,…

种群与进化 · 定量生物学 2019-01-04 Julien P. Renoult , Tamra C. Mendelson

Today, mobile robots are expected to carry out increasingly complex tasks in multifarious, real-world environments. Often, the tasks require a certain semantic understanding of the workspace. Consider, for example, spoken instructions from…

机器人学 · 计算机科学 2014-01-21 Javier Velez , Garrett Hemann , Albert S. Huang , Ingmar Posner , Nicholas Roy

Cells measure concentrations of external ligands by capturing ligand molecules with cell surface receptors. The numbers of molecules captured by different receptors co-vary because they depend on the same extrinsic ligand fluctuations.…

神经元与认知 · 定量生物学 2016-09-21 Vijay Singh , Martin Tchernookov , Ilya Nemenman

Learning to automatically perceive smell is becoming increasingly important with applications in monitoring the quality of food and drinks for healthy living. In todays age of proliferation of internet of things devices, the deployment of…

机器学习 · 计算机科学 2019-12-03 Kehinde Owoeye

The reliable detection of environmental molecules in the presence of noise is an important cellular function, yet the underlying computational mechanisms are not well understood. We introduce a model of two interacting sensors which allows…

生物物理 · 物理学 2020-02-25 Vudtiwat Ngampruetikorn , David J. Schwab , Greg J. Stephens

Autonomous neural systems must efficiently process information in a wide range of novel environments, which may have very different statistical properties. We consider the problem of how to optimally distribute receptors along a…

神经元与认知 · 定量生物学 2017-04-04 Marc W. Howard , Karthik H. Shankar

Mitral cells of the olfactory bulb form sparse representations of the odorants and transmit this information to the cortex. The olfactory code carried by the mitral cells is sparser than the inputs that they receive. In this study we…

神经元与认知 · 定量生物学 2010-03-01 Alexei A. Koulakov , Dmitry Rinberg

Cells use surface receptors to estimate the concentration of external ligands. Limits on the accuracy of such estimations have been well studied for pairs of ligand and receptor species. However, the environment typically contains many…

分子网络 · 定量生物学 2015-06-02 Vijay Singh , Ilya Nemenman

In natural scenes, objects generally appear together with other objects. Yet, theoretical studies of neural population coding typically focus on the encoding of single objects in isolation. Experimental studies suggest that neural responses…

神经元与认知 · 定量生物学 2015-01-05 A. Emin Orhan , Wei Ji Ma

Redundancies and correlations in the responses of sensory neurons seem to waste neural resources but can carry cues about structured stimuli and may help the brain to correct for response errors. To assess how the retina negotiates this…

神经元与认知 · 定量生物学 2014-03-05 K. D. Simmons , J. S. Prentice , G. Tkacik , J. Homann , H. K. Yee , S. E. Palmer , P. C. Nelson , V. Balasubramanian

Mitral cells, the principal neurons in the olfactory bulb, respond to odorants by firing bursts of action potentials called sharp events. A given cell produces a sharp event at a fixed phase during the sniff cycle in response to a given…

神经元与认知 · 定量生物学 2014-07-02 Honi Sanders , Brian Kolterman , Roman Shusterman , Dmitry Rinberg , Alexei A. Koulakov , John Lisman

In this paper, we propose a novel concept for engineered molecular communication (MC) systems inspired by animal olfaction. We focus on a multi-user scenario where transmitters employ unique mixtures of different types of signaling…

信息论 · 计算机科学 2022-04-19 Vahid Jamali , Helene M. Loos , Andrea Buettner , Robert Schober , H. Vincent Poor