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In clinical treatment, identifying potential adverse reactions of drugs can help assist doctors in making medication decisions. In response to the problems in previous studies that features are high-dimensional and sparse, independent…

定量方法 · 定量生物学 2024-07-30 Yufeng Li , Wenchao Zhao , Bo Dang , Xu Yan , Weimin Wang , Min Gao , Mingxuan Xiao

Simultaneous administration of multiple drugs can have synergistic or antagonistic effects as one drug can affect activities of other drugs. Synergistic effects lead to improved therapeutic outcomes, whereas, antagonistic effects can be…

计算与语言 · 计算机科学 2017-08-15 Sunil Kumar Sahu , Ashish Anand

The use of multiple drugs accounts for almost 30% of all hospital admission and is the 5th leading cause of death in America. Since over 30% of all adverse drug events (ADEs) are thought to be caused by drug-drug interactions (DDI), better…

定量方法 · 定量生物学 2020-09-02 Ricky Wang

Attention-based models have become the leading approach in modeling medical language for Natural Language Processing (NLP) in clinical notes. These models outperform traditional techniques by effectively capturing contextual representations…

计算与语言 · 计算机科学 2025-09-26 Tariq Abdul-Quddoos , Xishuang Dong , Lijun Qian

We present an analysis of the problem of identifying biological context and associating it with biochemical events in biomedical texts. This constitutes a non-trivial, inter-sentential relation extraction task. We focus on biological…

计算与语言 · 计算机科学 2018-12-18 Enrique Noriega-Atala , Paul D. Hein , Shraddha S. Thumsi , Zechy Wong , Xia Wang , Clayton T. Morrison

Relation Extraction (RE) aims to label relations between groups of marked entities in raw text. Most current RE models learn context-aware representations of the target entities that are then used to establish relation between them. This…

计算与语言 · 计算机科学 2019-02-26 Gaurav Singh , Parminder Bhatia

Adverse drug events (ADE) are prevalent and costly. Clinical trials are constrained in their ability to identify potential ADEs, motivating the development of spontaneous reporting systems for post-market surveillance. Statistical methods…

计算与语言 · 计算机科学 2020-08-11 Xiruo Ding , Trevor Cohen

With the advancements in Artificial intelligence (AI) and the accumulation of healthrelated big data, it has become increasingly feasible and commonplace to leverage machine learning technologies to analyze clinical and omics metadata to…

基因组学 · 定量生物学 2022-04-14 Attayeb Mohsen , Lokesh P. Tripathi , Kenji Mizuguchi

In recent years, there has been an increasing number of frameworks developed for biomedical entity and relation extraction. This research effort aims to address the accelerating growth in biomedical publications and the intricate nature of…

计算与语言 · 计算机科学 2024-08-14 Minh Nguyen , Phuong Le

Capturing interactions among event arguments is an essential step towards robust event argument extraction (EAE). However, existing efforts in this direction suffer from two limitations: 1) The argument role type information of contextual…

计算与语言 · 计算机科学 2021-07-02 Xiangyu Xi , Wei Ye , Shikun Zhang , Quanxiu Wang , Huixing Jiang , Wei Wu

We study the problem of event extraction from text data, which requires both detecting target event types and their arguments. Typically, both the event detection and argument detection subtasks are formulated as supervised sequence…

计算与语言 · 计算机科学 2020-10-23 Rui Feng , Jie Yuan , Chao Zhang

Recent works in relation extraction (RE) have achieved promising benchmark accuracy; however, our adversarial attack experiments show that these works excessively rely on entities, making their generalization capability questionable. To…

计算与语言 · 计算机科学 2024-04-05 Dawei Li , William Hogan , Jingbo Shang

Distantly supervised relation extraction intrinsically suffers from noisy labels due to the strong assumption of distant supervision. Most prior works adopt a selective attention mechanism over sentences in a bag to denoise from wrongly…

计算与语言 · 计算机科学 2019-11-28 Yang Li , Guodong Long , Tao Shen , Tianyi Zhou , Lina Yao , Huan Huo , Jing Jiang

Background: Drug-drug interactions (DDIs) refer to processes triggered by the administration of two or more drugs leading to side effects beyond those observed when drugs are administered by themselves. Due to the massive number of possible…

定量方法 · 定量生物学 2020-12-25 Kyriakos Schwarz , Ahmed Allam , Nicolas Andres Perez Gonzalez , Michael Krauthammer

Event extraction (EE), which acquires structural event knowledge from texts, can be divided into two sub-tasks: event type classification and element extraction (namely identifying triggers and arguments under different role patterns). As…

计算与语言 · 计算机科学 2022-08-19 Qian Li , Shu Guo , Jia Wu , Jianxin Li , Jiawei Sheng , Lihong Wang , Xiaohan Dong , Hao Peng

Recurrent Neural Networks (RNNs) have achieved remarkable performance on a range of tasks. A key step to further empowering RNN-based approaches is improving their explainability and interpretability. In this work we present MEME: a model…

机器学习 · 计算机科学 2021-04-15 Dmitry Kazhdan , Botty Dimanov , Mateja Jamnik , Pietro Liò

Argument structure extraction (ASE) aims to identify the discourse structure of arguments within documents. Previous research has demonstrated that contextual information is crucial for developing an effective ASE model. However, we observe…

计算与语言 · 计算机科学 2023-10-10 Yun Luo , Zhen Yang , Fandong Meng , Yingjie Li , Jie Zhou , Yue Zhang

Contextual Relation Extraction (CRE) is mainly used for constructing a knowledge graph with a help of ontology. It performs various tasks such as semantic search, query answering, and textual entailment. Relation extraction identifies the…

计算与语言 · 计算机科学 2023-09-14 R. Priyadharshini , G. Jeyakodi , P. Shanthi Bala

Adverse drug interactions are a critical concern in pharmacovigilance, as both clinical trials and spontaneous reporting systems often lack the breadth to detect complex drug interactions. This study introduces a computational framework for…

应用统计 · 统计学 2025-04-02 Jules Bangard , Einar Holsbø , Kristian Svendsen , Vittorio Perduca , Etienne Birmelé

We advance the state of the art in biomolecular interaction extraction with three contributions: (i) We show that deep, Abstract Meaning Representations (AMR) significantly improve the accuracy of a biomolecular interaction extraction…

计算与语言 · 计算机科学 2015-12-08 Sahil Garg , Aram Galstyan , Ulf Hermjakob , Daniel Marcu