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We consider the problem of model-based clustering in the presence of many correlated, mixed continuous and discrete variables, some of which may have missing values. Discrete variables are treated with a latent continuous variable approach…

In many biomedical research, multiple views of data (e.g., genomics, proteomics) are available, and a particular interest might be the detection of sample subgroups characterized by specific groups of variables. Biclustering methods are…

统计方法学 · 统计学 2021-11-12 W. Zhang , C. Wendt , R. Bowler , C. P. Hersh , S. E. Safo

Multiple types or views of data (e.g. genetics, proteomics) measured on the same set of individuals are now popularly generated in many biomedical studies. A particular interest might be the detection of sample subgroups (e.g. subtypes of…

统计方法学 · 统计学 2025-05-09 Kaifeng Yang , Thierry Chekouo , Sandra E. Safo

Disease heterogeneity has been a critical challenge for precision diagnosis and treatment, especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple distinct brain phenotypes across individuals, potentially…

Given genetic variations and various phenotypical traits, such as Magnetic Resonance Imaging (MRI) features, we consider two important and related tasks in biomedical research: i)to select genetic and phenotypical markers for disease…

机器学习 · 计算机科学 2013-10-17 Shandian Zhe , Zenglin Xu , Yuan Qi

ADHD is a prevalent disorder among the younger population. Standard evaluation techniques currently use evaluation forms, interviews with the patient, and more. However, its symptoms are similar to those of many other disorders like…

人工智能 · 计算机科学 2023-02-02 Abhishek Sharma , Arpit Jain , Shubhangi Sharma , Ashutosh Gupta , Prateek Jain , Saraju P. Mohanty

Multi-view data are increasingly prevalent in practice. It is often relevant to analyze the relationships between pairs of views by multi-view component analysis techniques such as Canonical Correlation Analysis (CCA). However, data may…

机器学习 · 统计学 2019-12-10 Eric Lei , Kyle Miller , Michael R. Pinsky , Artur Dubrawski

Epidemiology aims at identifying subpopulations of cohort participants that share common characteristics (e.g. alcohol consumption) to explain risk factors of diseases in cohort study data. These data contain information about the…

Understanding the biological and behavioral heterogeneity underlying psychiatric disorders is critical for advancing precision diagnosis, treatment, and prevention. This paper addresses the scientific question of how multimodal data,…

统计方法学 · 统计学 2025-11-10 Yinjun Zhao , Yuanjia Wang , Ying LIu

Integrating heterogeneous datasets across different measurement platforms is a fundamental challenge in many scientific applications. A common example arises in deconvolution problems, such as cell type deconvolution, where one aims to…

统计方法学 · 统计学 2025-09-30 Dongyue Xie , Lin Gui , Jingshu Wang

The Latent Block Model (LBM) is a prominent model-based co-clustering method, returning parametric representations of each block cluster and allowing the use of well-grounded model selection methods. The LBM, while adapted in literature to…

We consider dimension reduction of multiview data, which are emerging in scientific studies. Formulating multiview data as multi-variate data with block structures corresponding to the different views, or views of data, we estimate top…

统计方法学 · 统计学 2024-06-18 Lin Xiao , Luo Xiao

Bipolar Disorder (BD) is a complex disease. It is heterogeneous, both at the phenotypic and genetic level, although the extent and impact of this heterogeneity is not fully understood. In this paper, we leverage recent advances in…

Multi-view clustering has attracted much attention thanks to the capacity of multi-source information integration. Although numerous advanced methods have been proposed in past decades, most of them generally overlook the significance of…

计算机视觉与模式识别 · 计算机科学 2023-05-08 Rui Chen , Yongqiang Tang , Wensheng Zhang , Wenlong Feng

The multifactorial etiology of autism spectrum disorder (ASD) suggests that its study would benefit greatly from multimodal approaches that combine data from widely varying platforms, e.g., neuroimaging, genetics, and clinical…

定量方法 · 定量生物学 2023-08-11 Nicha C. Dvornek , Catherine Sullivan , James S. Duncan , Abha R. Gupta

Multi-view learning is widely applied to real-life datasets, such as multiple omics biological data, but it often suffers from both missing views and missing labels. Prior probabilistic approaches addressed the missing view problem by using…

机器学习 · 计算机科学 2025-08-18 Yiyang Shen , Weiran Wang

Although multi-view multi-label learning has been extensively studied, research on the dual-missing scenario, where both views and labels are incomplete, remains largely unexplored. Existing methods mainly rely on contrastive learning or…

计算机视觉与模式识别 · 计算机科学 2026-04-07 Xu Yan , Jun Yin , Shiliang Sun , Minghua Wan

Multi-view clustering leverages consistent and complementary information across multiple views to provide more comprehensive insights than single-view analysis. However, the heterogeneity and redundancy of multi-view data pose significant…

最优化与控制 · 数学 2025-08-12 Xiangru Xing , Yan Li , Xin Wang , Huangyue Chen , Xianchao Xiu

Understanding whether and how treatment effects vary across subgroups is crucial to inform clinical practice and recommendations. Accordingly, the assessment of heterogeneous treatment effects (HTE) based on pre-specified potential effect…

统计方法学 · 统计学 2023-12-04 Bryan S. Blette , Scott D. Halpern , Fan Li , Michael O. Harhay

We propose a novel method for multiple clustering that assumes a co-clustering structure (partitions in both rows and columns of the data matrix) in each view. The new method is applicable to high-dimensional data. It is based on a…

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