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Diffusion Magnetic Resonance Imaging (MRI) exploits the anisotropic diffusion of water molecules in the brain to enable the estimation of the brain's anatomical fiber tracts at a relatively high resolution. In particular, tractographic…

计算工程、金融与科学 · 计算机科学 2016-09-14 Yu Jin , Joseph F. JaJa , Rong Chen , Edward H. Herskovits

Functional networks characterize the coordinated neural activity observed by functional neuroimaging. The prevalence of different networks during resting state periods provide useful features for predicting the trajectory of…

信号处理 · 电气工程与系统科学 2021-11-16 Hassan Baker , Austin J. Brockmeier

High-throughput methods for yielding the set of connections in a neural system, the connectome, are now being developed. This tutorial describes ways to analyze the topological and spatial organization of the connectome at the macroscopic…

神经元与认知 · 定量生物学 2011-12-23 Marcus Kaiser

The question of controllability of natural and man-made network systems has recently received considerable attention. In the context of the human brain, the study of controllability may not only shed light into the organization and function…

最优化与控制 · 数学 2021-02-10 Tommaso Menara , Shi Gu , Danielle S. Bassett , Fabio Pasqualetti

Self-organization and pattern formation in network-organized systems emerges from the collective activation and interaction of many interconnected units. A striking feature of these non-equilibrium structures is that they are often…

物理与社会 · 物理学 2016-02-23 Christos Nicolaides , Ruben Juanes , Luis Cueto-Felgueroso

In order to understand the complex cognitive functions of the human brain, it is essential to study the structural connectome, i.e., the wiring of different brain regions to each other through axonal pathways. However, the high degree of…

神经元与认知 · 定量生物学 2021-01-25 Anand Pathak , Shakti N. Menon , Sitabhra Sinha

Recurrent neural networks (RNNs) trained on low-dimensional tasks have been widely used to model functional biological networks. However, the solutions found by learning and the effect of initial connectivity are not well understood. Here,…

神经元与认知 · 定量生物学 2021-05-17 Friedrich Schuessler , Francesca Mastrogiuseppe , Alexis Dubreuil , Srdjan Ostojic , Omri Barak

Understanding the human brain remains the Holy Grail in biomedical science, and arguably in all of the sciences. Our brains represent the most complex systems in the world (and some contend the universe) comprising nearly one hundred…

定量方法 · 定量生物学 2016-02-03 Sean L. Simpson , Paul J. Laurienti

A computer model is described which is used to assess the dynamical complexity of a class of networks of spiking neurons with small-world properties. Networks are constructed by forming an initially segregated set of highly intra-connected…

生物物理 · 物理学 2009-11-13 Murray Shanahan

Signal propagation along the structural connectome of the brain induces changes in the patterns of activity. These activity patterns define global brain states and contain information in accordance with their expected probability of…

The connectivity of individual neurons of large neural networks determine both the steady state activity of the network and its answer to external stimulus. Highly diluted random networks have zero activity. We show that increasing the…

凝聚态物理 · 物理学 2008-02-03 Albert-László Barabási

Typical brain networks consist of many peripheral regions and a few highly central ones, i.e. hubs, playing key functional roles in cerebral inter-regional interactions. Studies have shown that networks, obtained from the analysis of…

神经元与认知 · 定量生物学 2016-07-19 Manlio De Domenico , Shuntaro Sasai , Alex Arenas

Functional connectivity (FC) refers to the investigation of interactions between brain regions to understand integration of neural activity in several regions. FC is often estimated using functional magnetic resonance images (fMRI). There…

应用统计 · 统计学 2023-01-24 Nathan Tung , Jerome Sanes , Eli Upfal , Ani Eloyan

The human brain has a complex, intricate functional architecture. While many studies primarily emphasize pairwise interactions, delving into high-order associations is crucial for a comprehensive understanding of how functional brain…

神经元与认知 · 定量生物学 2023-10-30 Qiang Li , Vince D. Calhoun , Adithya Ram Ballem , Shujian Yu , Jesus Malo , Armin Iraji

The idea to estimate the statistical interdependence among (interacting) brain regions has motivated numerous researchers to investigate how the resulting connectivity patterns and networks may organize themselves under any conceivable…

神经元与认知 · 定量生物学 2021-02-03 Matteo Fraschini , Simone Maurizio La Cava , Luca Didaci , Luigi Barberini

Neural networks are high-dimensional nonlinear dynamical systems that process information through the coordinated activity of many connected units. Understanding how biological and machine-learning networks function and learn requires…

神经元与认知 · 定量生物学 2023-09-13 David G. Clark , L. F. Abbott , Ashok Litwin-Kumar

A theoretical framework describing the set of interactions between neurons in the brain, or functional connectivity, should include dynamical functions representing the propagation of signal from one neuron to another. Green's functions and…

神经元与认知 · 定量生物学 2021-03-24 Francesco Randi , Andrew M. Leifer

Functional magnetic resonance imaging (fMRI) data is characterized by its complexity and high--dimensionality, encompassing signals from various regions of interests (ROIs) that exhibit intricate correlations. Analyzing fMRI data directly…

应用统计 · 统计学 2024-01-18 Yeseul Jeon , Jeong-Jae Kim , SuMin Yu , Junggu Choi , Sanghoon Han

Many recent efforts in computational modeling of macro-scale brain dynamics have begun to take a data-driven approach by incorporating structural and/or functional information derived from subject data. Here, we discuss recent work using…

神经元与认知 · 定量生物学 2018-11-15 Kanika Bansal , Johan Nakuci , Sarah Feldt Muldoon

It has been said that complexity lies between order and disorder. In the case of brain activity, and physiology in general, complexity issues are being considered with increased emphasis. We sought to identify features of brain organization…

神经元与认知 · 定量生物学 2017-01-11 R. Guevara Erra , D. M. Mateos , R. Wennberg , J. L. Perez Velazquez