相关论文: Mechanical model of Golgi apparatus
The thesis is about an application of the shape optimization to the morphological evolution of Golgi stack. Golgi stack consists of multiple layers of cisternae. It is an organelle in the biological cells. Inspired by the Helfrich Model…
Organelle patterning and its heritability remain central mysteries in cell biology, highlighting the fundamental tension between genetic inheritance and self-assembly. Here, we explore the nonequilibrium assembly and emdedded size control…
From the Golgi apparatus to endosomes, organelles in the endomembrane system exhibit complex and varied morphologies that are often related to their function. Such membrane-bound organelles operate far from equilibrium due to directed…
The dynamical organization of membrane-bound organelles along intracellular transport pathways relies on vesicular exchange between organelles and on biochemical maturation of the organelle content by specific enzymes. The relative…
A central issue in cell biology is the physico-chemical basis of organelle biogenesis in intracellular trafficking pathways, its most impressive manifestation being the biogenesis of Golgi cisternae. At a basic level, such morphologically…
The mechanisms controlling the transport of proteins across the Golgi stack of mammalian and plant cells is the subject of intense debate, with two models, cisternal progression and inter-cisternal exchange, emerging as major contenders. A…
The generation of two non-identical membrane compartments via exchange of vesicles is considered to require two types of vesicles specified by distinct cytosolic coats that selectively recruit cargo and two membrane-bound SNARE pairs that…
Despite the enormous theoretical and application interests, a fundamental understanding of the glassy dynamics remains elusive. The static properties of glassy and ordinary liquids are similar, but their dynamics are dramatically different.…
We study fundamental groups of algebraic stacks. We show that these fundamental groups carry an additional structure coming from the inertia groups. Then use this additional structure to analyze geometric/ topological properties of stacks.…
Recent literature indicates that attractive interactions between particles of a dense liquid play a secondary role in determining its bulk mechanical properties. Here we show that, in contrast with their apparent unimportance to the bulk…
This paper is largely concerned with constructing coarse moduli spaces for Artin stacks. The main purpose of this paper is to introduce the notion of stability on an arbitrary Artin stack and construct a coarse moduli space for the open…
The purpose of the study is to further investigate the classical Gibbs analysis of the heterogeneous system "stressed crystal - melt." It is demonstrated that each equilibrium configuration is stable with respect to a special class of…
We study the dynamics of a one-dimensional fluid of orientable hard rectangles with a non-coarse-grained microscopic mechanism of facilitation. The length occupied by a rectangle depends on its orientation, which is coupled to an external…
The interface shape of a fluid in rigid body rotation about its axis and partially filling the container is often the subject of a homework problem in the first graduate fluids class. In that problem, surface tension is neglected, the…
How pattern and form are generated in a reproducible manner during embryogenesis remains poorly understood. Intestinal organoid morphogenesis involves a number of mechanochemical regulators, including cell-type specific cytoskeletal forces…
We study the geometry of the moduli stack of torsion-free sheaves on ribbons. We introduce a stratification of the stack by the complete type of the sheaves, and we investigate the geometric properties of the strata and their closure…
Moduli theory has captured the imagination of algebraic geometers for at least two centuries. Up until the end of the 20th century, moduli spaces were constructed and studied by rigidifying the moduli problem using extrinsic data and…
In this paper we focus on the mechanical properties of oligomeric glasses (waxes), employing a microscopic model that provides, via numerical simulations, information about the shear modulus of such materials, the failure mechanism via…
Deformations of heavy elastic cylinders with their axis in the direction of earth's gravity field are investigated. The specimens, made of polyacrylamide hydrogels, are attached from their top circular cross section to a rigid plate. An…
We discuss the statistical mechanics of a gas of gauged vortices in the canonical formalism. At critical self-coupling, and for low temperatures, it has been argued that the configuration space for vortex dynamics in each topological class…