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Tandem duplication is the process of inserting a copy of a segment of DNA adjacent to the original position. Motivated by applications that store data in living organisms, Jain et al. (2017) proposed the study of codes that correct tandem…

信息论 · 计算机科学 2018-01-09 Yeow Meng Chee , Johan Chrisnata , Han Mao Kiah , Tuan Thanh Nguyen

A tandem duplication denotes the process of inserting a copy of a segment of DNA adjacent to its original position. More formally, a tandem duplication can be thought of as an operation that converts a string $S = AXB$ into a string $T =…

计算复杂性 · 计算机科学 2021-03-16 Ferdinando Cicalese , Nicolò Pilati

The set of all $ q $-ary strings that do not contain repeated substrings of length $ \leqslant\! 3 $ (i.e., that do not contain substrings of the form $ a a $, $ a b a b $, and $ a b c a b c $) constitutes a code correcting an arbitrary…

信息论 · 计算机科学 2022-07-01 Mladen Kovačević

The ability to store data in the DNA of a living organism has applications in a variety of areas including synthetic biology and watermarking of patented genetically-modified organisms. Data stored in this medium is subject to errors…

信息论 · 计算机科学 2016-11-17 Siddharth Jain , Farzad Farnoud , Moshe Schwartz , Jehoshua Bruck

Tandem duplication is an evolutionary process whereby a segment of DNA is replicated and proximally inserted. The different configurations that can arise from this process give rise to some interesting combinatorial questions. Firstly, we…

组合数学 · 数学 2016-11-25 L Penso-Dolfin , CD Greenman

Due to its high data density and longevity, DNA is considered a promising medium for satisfying ever-increasing data storage needs. However, the diversity of errors that occur in DNA sequences makes efficient error-correction a challenging…

信息论 · 计算机科学 2020-11-12 Yuanyuan Tang , Farzad Farnoud

A (tandem) duplication of length $ k $ is an insertion of an exact copy of a substring of length $ k $ next to its original position. This and related types of impairments are of relevance in modeling communication in the presence of…

信息论 · 计算机科学 2020-08-13 Mladen Kovačević , Vincent Y. F. Tan

In computational biology, tandem duplication is an important biological phenomenon which can occur either at the genome or at the DNA level. A tandem duplication takes a copy of a genome segment and inserts it right after the segment - this…

数据结构与算法 · 计算机科学 2019-06-13 Manuel Lafond , Binhai Zhu , Peng Zou

Because of its high data density and longevity, DNA is emerging as a promising candidate for satisfying increasing data storage needs. Compared to conventional storage media, however, data stored in DNA is subject to a wider range of errors…

信息论 · 计算机科学 2020-08-20 Yuanyuan Tang , Farzad Farnoud

Motivated by applications in DNA storage, we study a setting in which strings are affected by tandem-duplication errors. In particular, we look at two settings: disjoint tandem-duplication errors, and equal-length tandem-duplication errors.…

信息论 · 计算机科学 2024-01-10 Wenjun Yu , Moshe Schwartz

In this work, we propose constructions that correct duplications of multiple consecutive symbols. These errors are known as tandem duplications, where a sequence of symbols is repeated; respectively as palindromic duplications, where a…

信息论 · 计算机科学 2017-12-29 Andreas Lenz , Antonia Wachter-Zeh , Eitan Yaakobi

Motivated by applications in in-vivo DNA storage, we study codes for correcting duplications. A reverse-complement duplication of length $k$ is the insertion of the reversed and complemented copy of a substring of length $k$ adjacent to its…

信息论 · 计算机科学 2026-02-03 Yubo Sun , Gennian Ge

We propose a list-decoding scheme for reconstruction codes in the context of uniform-tandem-duplication noise, which can be viewed as an application of the associative memory model to this setting. We find the uncertainty associated with…

信息论 · 计算机科学 2021-06-30 Yonatan Yehezkeally , Moshe Schwartz

Due to its higher data density, longevity, energy efficiency, and ease of generating copies, DNA is considered a promising storage technology for satisfying future needs. However, a diverse set of errors including deletions, insertions,…

信息论 · 计算机科学 2022-08-05 Yuanyuan Tang , Shuche Wang , Hao Lou , Ryan Gabrys , Farzad Farnoud

We consider the problem of efficiently designing sets (codes) of equal-length DNA strings (words) that satisfy certain combinatorial constraints. This problem has numerous motivations including DNA computing and DNA self-assembly. Previous…

数据结构与算法 · 计算机科学 2007-05-23 Ming-Yang Kao , Manan Sanghi , Robert Schweller

We study codes that can correct backtracking errors during nanopore sequencing. In this channel, a sequence of length $n$ over an alphabet of size $q$ is being read by a sliding window of length $\ell$, where from each window we obtain only…

信息论 · 计算机科学 2024-08-16 Wenjun Yu , Zuo Ye , Moshe Schwartz

Designing short DNA words is a problem of constructing a set (i.e., code) of n DNA strings (i.e., words) with the minimum length such that the Hamming distance between each pair of words is at least k and the n words satisfy a set of…

数据结构与算法 · 计算机科学 2012-02-01 Ming-Yang Kao , Henry C. M. Leung , He Sun , Yong Zhang

Twins in a finite word are formed by a pair of identical subwords placed at disjoint sets of positions. We investigate the maximum length of twins in a random word over a $k$-letter alphabet. The obtained lower bounds for small values of…

组合数学 · 数学 2023-04-25 Andrzej Dudek , Jarosław Grytczuk , Andrzej Ruciński

DNA as a data storage medium has several advantages, including far greater data density compared to electronic media. We propose that schemes for data storage in the DNA of living organisms may benefit from studying the reconstruction…

信息论 · 计算机科学 2019-09-10 Yonatan Yehezkeally , Moshe Schwartz

We consider the problem of identifying tandem scattered subsequences within a string. Our algorithm identifies a longest subsequence which occurs twice without overlap in a string. This algorithm is based on the Hunt-Szymanski algorithm,…

数据结构与算法 · 计算机科学 2020-06-26 Luís M. S. Russo , Alexandre P. Francisco
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