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We investigate several scaling properties of a translocating homopolymer through a thin pore driven by an external field present inside the pore only using Langevin Dynamics (LD) simulation in three dimension (3D). Specifically motivated by…

Theoretical derivation and numerical confirmation are provided for the scaling of pore-blockade times as $N^{2+\nu}$ for unbiased translocation in two and three dimensions, with $N$ as the polymer length and $\nu$ as the Flory exponent of…

软凝聚态物质 · 物理学 2010-02-12 Debabrata Panja , Gerard T. Barkema

We determine the scaling exponents of polymer translocation (PT) through a nanopore by extensive computer simulations of various microscopic models for chain lengths extending up to N=800 in some cases. We focus on the scaling of the…

DNA translocation through nanopores is one of the most promising strategies for the next-generation sequencing technologies. Most part of experimental and numerical works has focused on polymer translocation biased by electrophoresis, where…

软凝聚态物质 · 物理学 2018-02-07 Timothée Menais

We present a numerical study of forced polymer translocation by using two separate pore models. Both of them have been extensively used in previous forced translocation studies. We show that variations in the pore model affect the forced…

生物物理 · 物理学 2015-05-19 V. V. Lehtola , K. Kaski , R. P. Linna

We study the driven translocation of a flexible polymer through an interacting conical pore using Langevin dynamics simulations. We find that, for a fixed value of externally applied force and pore polymer interaction strength, the mean…

软凝聚态物质 · 物理学 2021-02-17 Rajneesh Kumar , Abhishek Chaudhuri , Rajeev Kapri

We study pore blockade times for a translocating polymer of length $N$, driven by a field $E$ across the pore in three dimensions. The polymer performs Rouse dynamics, i.e., we consider polymer dynamics in the absence of hydrodynamical…

软凝聚态物质 · 物理学 2008-02-15 Henk Vocks , Debabrata Panja , Gerard T. Barkema , Robin C. Ball

Polymer translocation has long been a topic of interest in the field of biological physics given its relevance in both biological (protein and DNA/RNA translocation through nuclear and cell membranes) and technological processes (nanopore…

软凝聚态物质 · 物理学 2023-09-11 Alejandro Sainz-Agost , Fernando Falo , Alessandro Fiasconaro

Langevin Dynamics simulations of polymer translocation are performed where the polymer is stretched via two opposing forces applied on the first and last monomer before and during translocation. In this setup, polymer translocation is…

软凝聚态物质 · 物理学 2018-08-08 Hendrick W. de Haan , David Sean , Gary W. Slater

We consider the passage of long polymers of length N through a hole in a membrane. If the process is slow, it is in principle possible to focus on the dynamics of the number of monomers s on one side of the membrane, assuming that the two…

软凝聚态物质 · 物理学 2009-11-10 Yacov Kantor , Mehran Kardar

I did off-lattice 3D Monte Carlo simulations for polymer translocation through a narrow pore at low external field, trying to be as close to a direct approach as possible. The process was found non equilibrium globally, but dynamics of the…

软凝聚态物质 · 物理学 2008-06-18 Stanislav Kotsev

We investigate the problem of polymer translocation through a nanopore in the absence of an external driving force. To this end, we use the two-dimensional (2D) fluctuating bond model with single-segment Monte Carlo moves. To overcome the…

计算物理 · 物理学 2012-12-06 Kaifu Luo , Tapio Ala-Nissila , See-chen Ying

We study the translocation of a flexible polymer through a pore in a membrane induced by its adsorption on \trans side of the membrane. When temperature $T$ is higher than $T_c$, the adsorption-desorption transition temperature, attractive…

软凝聚态物质 · 物理学 2009-10-31 Pyeong Jun Park , Wokyung Sung

We use the Bond Fluctuation Model (BFM) to study the pore-blockade times of a translocating polymer of length $N$ in two dimensions, in the absence of external forces on the polymer (i.e., unbiased translocation) and hydrodynamic…

软凝聚态物质 · 物理学 2010-01-05 Debabrata Panja , Gerard T. Barkema

One of the most fundamental quantities associated with polymer translocation through a nanopore is the translocation time $\tau$ and its dependence on the chain length $N$. Our simulation results based on both the bond fluctuation Monte…

软凝聚态物质 · 物理学 2008-11-08 Kaifu Luo , Tapio Ala-Nissila , See-Chen Ying , Pawel Pomorski , Mikko Karttunen

We investigate the dynamics of polymer translocation through a nanopore under an externally applied field using the 2D fluctuating bond model with single-segment Monte Carlo moves. We concentrate on the influence of the field strength $E$,…

软凝聚态物质 · 物理学 2011-08-26 Kaifu Luo , Ilkka Huopaniemi , Tapio Ala-Nissila , See-Chen Ying

The motion of polymers with inhomogeneous structure through nanopores is discussed theoretically. Specifically, we consider the translocation dynamics of polymers consisting of double-stranded and single-stranded blocks. Since only the…

统计力学 · 物理学 2009-11-11 Stanislav Kotsev , Anatoly B. Kolomeisky

We investigate the influence of polymer-pore interactions on the translocation dynamics using Langevin dynamics simulations. An attractive interaction can greatly improve translocation probability. At the same time, it also increases…

软凝聚态物质 · 物理学 2007-10-01 Kaifu Luo , Tapio Ala-Nissila , See-chen Ying , Aniket Bhattacharya

We study the driven translocation of polymers under time-dependent driving forces using $N$-particle Langevin dynamics simulations. We consider the force to be either sinusoidally oscillating in time or dichotomic noise with exponential…

软凝聚态物质 · 物理学 2015-06-12 Timo Ikonen , Jaeoh Shin , Tapio Ala-Nissila , Wokyung Sung

Translocation through a nanopore is a new experimental technique to probe physical properties of biomolecules. A bulk of theoretical and computational work exists on the dependence of the time to translocate a single unstructured molecule…

生物大分子 · 定量生物学 2009-05-04 Malcolm McCauley , Robert Forties , Ulrich Gerland , Ralf Bundschuh