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Cellular Electron Cryo-Tomography (CECT) is a powerful imaging technique for the 3D visualization of cellular structure and organization at submolecular resolution. It enables analyzing the native structures of macromolecular complexes and…

定量方法 · 定量生物学 2018-05-16 Chang Liu , Xiangrui Zeng , Ruogu Lin , Xiaodan Liang , Zachary Freyberg , Eric Xing , Min Xu

Cryo-electron tomography (Cryo-ET) is a 3D imaging technique that enables the systemic study of shape, abundance, and distribution of macromolecular structures in single cells in near-atomic resolution. However, the systematic and efficient…

生物大分子 · 定量生物学 2021-06-29 Kai Yi , Jianye Pang , Yungeng Zhang , Xiangrui Zeng , Min Xu

Motivation: Cellular Electron CryoTomography (CECT) enables 3D visualization of cellular organization at near-native state and in sub-molecular resolution, making it a powerful tool for analyzing structures of macromolecular complexes and…

定量方法 · 定量生物学 2017-04-14 Min Xu , Xiaoqi Chai , Hariank Muthakana , Xiaodan Liang , Ge Yang , Tzviya Zeev-Ben-Mordehai , Eric Xing

Cellular Electron Cryotomography (CryoET) offers the ability to look inside cells and observe macromolecules frozen in action. A primary challenge for this technique is identifying and extracting the molecular components within the crowded…

定量方法 · 定量生物学 2021-08-04 Muyuan Chen , Wei Dai , Ying Sun , Darius Jonasch , Cynthia Y He , Michael F. Schmid , Wah Chiu , Steven J Ludtke

Hyperspectral image analysis has become an important topic widely researched by the remote sensing community. Classification and segmentation of such imagery help understand the underlying materials within a scanned scene, since…

计算机视觉与模式识别 · 计算机科学 2020-12-02 Jakub Nalepa , Michal Myller , Yasuteru Imai , Ken-ichi Honda , Tomomi Takeda , Marek Antoniak

Diagnosing hematological malignancies requires identification and classification of white blood cells in peripheral blood smears. Domain shifts caused by different lab procedures, staining, illumination, and microscope settings hamper the…

计算机视觉与模式识别 · 计算机科学 2022-07-04 Raheleh Salehi , Ario Sadafi , Armin Gruber , Peter Lienemann , Nassir Navab , Shadi Albarqouni , Carsten Marr

Learning latent representations of registered meshes is useful for many 3D tasks. Techniques have recently shifted to neural mesh autoencoders. Although they demonstrate higher precision than traditional methods, they remain unable to…

计算机视觉与模式识别 · 计算机科学 2020-10-22 Yi Zhou , Chenglei Wu , Zimo Li , Chen Cao , Yuting Ye , Jason Saragih , Hao Li , Yaser Sheikh

Automatic segmentation of anatomical structures with convolutional neural networks (CNNs) constitutes a large portion of research in medical image analysis. The majority of CNN-based methods rely on an abundance of labeled data for proper…

图像与视频处理 · 电气工程与系统科学 2020-03-20 Cheryl Sital , Tom Brosch , Dominique Tio , Alexander Raaijmakers , Jürgen Weese

Cryo-electron microscopy (cryo-EM) is capable of producing reconstructed 3D images of biomolecules at near-atomic resolution. As such, it represents one of the most promising imaging techniques in structural biology. However, raw cryo-EM…

定量方法 · 定量生物学 2021-05-25 Nina Miolane , Frédéric Poitevin , Yee-Ting Li , Susan Holmes

Spatially localized deformation components are very useful for shape analysis and synthesis in 3D geometry processing. Several methods have recently been developed, with an aim to extract intuitive and interpretable deformation components.…

图形学 · 计算机科学 2017-12-19 Qingyang Tan , Lin Gao , Yu-Kun Lai , Jie Yang , Shihong Xia

The analysis of deforming 3D surface meshes is accelerated by autoencoders since the low-dimensional embeddings can be used to visualize underlying dynamics. But, state-of-the-art mesh convolutional autoencoders require a fixed connectivity…

计算机视觉与模式识别 · 计算机科学 2021-10-22 Sara Hahner , Jochen Garcke

Advancements in digital imaging technologies have sparked increased interest in using multiplexed immunofluorescence (mIF) images to visualise and identify the interactions between specific immunophenotypes with the tumour microenvironment…

图像与视频处理 · 电气工程与系统科学 2024-07-01 Piumi Sandarenu , Julia Chen , Iveta Slapetova , Lois Browne , Peter H. Graham , Alexander Swarbrick , Ewan K. A. Millar , Yang Song , Erik Meijering

Feature selection is a dimensionality reduction technique that selects a subset of representative features from high dimensional data by eliminating irrelevant and redundant features. Recently, feature selection combined with sparse…

计算机视觉与模式识别 · 计算机科学 2018-04-24 Siwei Feng , Marco F. Duarte

In this work we introduce an Autoencoder for molecular conformations. Our proposed model converts the discrete spatial arrangements of atoms in a given molecular graph (conformation) into and from a continuous fixed-sized latent…

机器学习 · 计算机科学 2021-01-06 Robin Winter , Frank Noé , Djork-Arné Clevert

Cryogenic electron microscopy (cryo-EM) provides a unique opportunity to study the structural heterogeneity of biomolecules. Being able to explain this heterogeneity with atomic models would help our understanding of their functional…

Cryo-electron tomography enables 3D visualization of cells in a near native state at molecular resolution. The produced cellular tomograms contain detailed information about all macromolecular complexes, their structures, their abundances…

定量方法 · 定量生物学 2019-04-30 Min Xu , Elitza I Tocheva , Yi-Wei Chang , Grant J Jensen , Frank Alber

Electron Cryo-Tomography (ECT) allows 3D visualization of subcellular structures at the submolecular resolution in close to the native state. However, due to the high degree of structural complexity and imaging limits, the automatic…

定量方法 · 定量生物学 2019-08-08 Bo Zhou , Qiang Guo , Xiangrui Zeng , Min Xu

Electron and scanning probe microscopy produce vast amounts of data in the form of images or hyperspectral data, such as EELS or 4D STEM, that contain information on a wide range of structural, physical, and chemical properties of…

机器学习 · 计算机科学 2023-06-09 Arpan Biswas , Maxim Ziatdinov , Sergei V. Kalinin

Protein function is inherently linked to its localization within the cell, and fluorescent microscopy data is an indispensable resource for learning representations of proteins. Despite major developments in molecular representation…

定量方法 · 定量生物学 2022-05-25 Anastasia Razdaibiedina , Alexander Brechalov

In this paper, we introduce a novel 3D mesh convolution-based autoencoder for geometry compression, able to deal with irregular mesh data without requiring neither preprocessing nor manifold/watertightness conditions. The proposed approach…

计算机视觉与模式识别 · 计算机科学 2026-03-03 Germain Bregeon , Marius Preda , Radu Ispas , Titus Zaharia
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