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Recent developments in high throughput profiling of individual neurons have spurred data driven exploration of the idea that there exist natural groupings of neurons referred to as cell types. The promise of this idea is that the immense…

神经元与认知 · 定量生物学 2019-11-14 Rohan Gala , Nathan Gouwens , Zizhen Yao , Agata Budzillo , Osnat Penn , Bosiljka Tasic , Gabe Murphy , Hongkui Zeng , Uygar Sümbül

Cellular processes are governed by macromolecular complexes inside the cell. Study of the native structures of macromolecular complexes has been extremely difficult due to lack of data. With recent breakthroughs in Cellular electron cryo…

定量方法 · 定量生物学 2018-06-12 Chengqian Che , Ruogu Lin , Xiangrui Zeng , Karim Elmaaroufi , John Galeotti , Min Xu

The idea of using a deep autoencoder to encode seismic waveform features and then use them in different seismological applications is appealing. In this paper, we designed tests to evaluate this idea of using autoencoders as feature…

Cryo-electron microscopy (cryo-EM) allows for the high-resolution reconstruction of 3D structures of proteins and other biomolecules. Successful reconstruction of both shape and movement greatly helps understand the fundamental processes of…

计算机视觉与模式识别 · 计算机科学 2023-10-12 Xinhang Liu , Yan Zeng , Yifan Qin , Hao Li , Jiakai Zhang , Lan Xu , Jingyi Yu

The gap between our ability to collect interesting data and our ability to analyze these data is growing at an unprecedented rate. Recent algorithmic attempts to fill this gap have employed unsupervised tools to discover structure in data.…

机器学习 · 计算机科学 2018-01-23 Genevieve Flaspohler , Nicholas Roy , Yogesh Girdhar

This work proposed kernel selection approaches for probabilistic classifiers based on features produced by the convolutional encoder of a variational autoencoder. Particularly, the developed methodologies allow the selection of the most…

Cryo-Electron Tomography (cryo-ET) is a 3D imaging technology that enables the visualization of subcellular structures in situ at near-atomic resolution. Cellular cryo-ET images help in resolving the structures of macromolecules and…

Cryo-electron microscopy (cryo-EM) is an emerging experimental method to characterize the structure of large biomolecular assemblies. Single particle cryo-EM records 2D images (so-called micrographs) of projections of the three-dimensional…

应用统计 · 统计学 2013-12-02 Mikhail Langovoy , Michael Habeck , Bernhard Schoelkopf

Autoencoding is a popular method in representation learning. Conventional autoencoders employ symmetric encoding-decoding procedures and a simple Euclidean latent space to detect hidden low-dimensional structures in an unsupervised way.…

机器学习 · 计算机科学 2024-10-07 Stefan C. Schonsheck , Scott Mahan , Timo Klock , Alexander Cloninger , Rongjie Lai

Gene expression profiles have been widely used to characterize patterns of cellular responses to diseases. As data becomes available, scalable learning toolkits become essential to processing large datasets using deep learning models to…

机器学习 · 计算机科学 2019-02-01 Ya Ju Fan , Jonathan E. Allen , Sam Ade Jacobs , Brian C. Van Essen

Modeling the 3D structures of cells and tissues is crucial in biology. Sequential cross-sectional images from electron microscopy provide high-resolution intracellular structure information. The segmentation of complex cell structures…

定量方法 · 定量生物学 2025-02-14 Jin Kousaka , Atsuko H. Iwane , Yuichi Togashi

Cryo-electron tomography (cryo-ET) has emerged as a powerful tool for studying the structural heterogeneity of proteins and their complexes, offering insights into macromolecular dynamics directly within cells. Driven by recent…

生物大分子 · 定量生物学 2025-07-01 Jackson Carrion , Joseph H. Davis

Cell detection in microscopy images is important to study how cells move and interact with their environment. Most recent deep learning-based methods for cell detection use convolutional neural networks (CNNs). However, inspired by the…

图像与视频处理 · 电气工程与系统科学 2022-06-15 Royden Wagner , Karl Rohr

This work investigates a practical and novel method for automated unsupervised fault detection in vehicles using a fully convolutional autoencoder. The results demonstrate the algorithm we developed can detect anomalies which correspond to…

机器学习 · 计算机科学 2024-09-10 Anthony Geglio , Eisa Hedayati , Mark Tascillo , Dyche Anderson , Jonathan Barker , Timothy C. Havens

Cellular Electron Cryo-Tomography (CECT) is a powerful 3D imaging tool for studying the native structure and organization of macromolecules inside single cells. For systematic recognition and recovery of macromolecular structures captured…

计算机视觉与模式识别 · 计算机科学 2018-07-04 Chang Liu , Xiangrui Zeng , Kaiwen Wang , Qiang Guo , Min Xu

Autoencoders are unsupervised deep learning models used for learning representations. In literature, autoencoders have shown to perform well on a variety of tasks spread across multiple domains, thereby establishing widespread…

计算机视觉与模式识别 · 计算机科学 2018-10-16 Maneet Singh , Shruti Nagpal , Mayank Vatsa , Richa Singh , Afzel Noore

Automatic detecting anomalous regions in images of objects or textures without priors of the anomalies is challenging, especially when the anomalies appear in very small areas of the images, making difficult-to-detect visual variations,…

计算机视觉与模式识别 · 计算机科学 2022-07-05 Jie Yang , Yong Shi , Zhiquan Qi

This work contributes to breast cancer sub-type classification using histopathological images. We utilize masked autoencoders (MAEs) to learn a self-supervised embedding tailored for computer vision tasks in this domain. This embedding…

计算机视觉与模式识别 · 计算机科学 2025-06-10 Annalisa Chiocchetti , Marco Dossena , Christopher Irwin , Luigi Portinale

Binary change detection in bi-temporal co-registered hyperspectral images is a challenging task due to a large number of spectral bands present in the data. Researchers, therefore, try to handle it by reducing dimensions. The proposed work…

计算机视觉与模式识别 · 计算机科学 2021-09-13 Debasrita Chakraborty , Ashish Ghosh

We present a conditional generative model to learn variation in cell and nuclear morphology and the location of subcellular structures from microscopy images. Our model generalizes to a wide range of subcellular localization and allows for…

机器学习 · 统计学 2017-05-02 Gregory R. Johnson , Rory M. Donovan-Maiye , Mary M. Maleckar