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Previous work has highlighted that existing post-hoc explanation methods exhibit disparities in explanation fidelity (across 'race' and 'gender' as sensitive attributes), and while a large body of work focuses on mitigating these issues at…

机器学习 · 计算机科学 2024-01-29 Vishwali Mhasawade , Salman Rahman , Zoe Haskell-Craig , Rumi Chunara

The recent advancements in Deep Learning models and techniques have led to significant strides in performance across diverse tasks and modalities. However, while the overall capabilities of models show promising growth, our understanding of…

人工智能 · 计算机科学 2025-04-04 Erik Arakelyan

Predicting the bioactivity of a ligand is one of the hardest and most important challenges in computer-aided drug discovery. Despite years of data collection and curation efforts by research organizations worldwide, bioactivity data remains…

定量方法 · 定量生物学 2023-08-21 Lucian Chan , Marcel Verdonk , Carl Poelking

The study of model bias and variance with respect to decision boundaries is critically important in supervised classification. There is generally a tradeoff between the two, as fine-tuning of the decision boundary of a classification model…

机器学习 · 计算机科学 2020-02-25 Matthew Almeida , Wei Ding , Scott Crouter , Ping Chen

When we use the normal mixture model, the optimal number of the components describing the data should be determined. Testing homogeneity is good for this purpose; however, to construct its theory is challenging, since the test statistic…

统计理论 · 数学 2019-12-24 Natsuki Kariya , Sumio Watanabe

A commonly observed pattern in machine learning models is an underprediction of the target feature, with the model's predicted target rate for members of a given category typically being lower than the actual target rate for members of that…

机器学习 · 计算机科学 2023-07-06 Owen O'Neill , Fintan Costello

Homogeneity bias in Large Language Models (LLMs) refers to their tendency to homogenize the representations of some groups compared to others. Previous studies documenting this bias have predominantly used encoder models, which may have…

计算与语言 · 计算机科学 2024-12-13 Messi H. J. Lee , Calvin K. Lai

Classical learning theory suggests that the optimal generalization performance of a machine learning model should occur at an intermediate model complexity, with simpler models exhibiting high bias and more complex models exhibiting high…

机器学习 · 统计学 2020-11-09 Ben Adlam , Jeffrey Pennington

Development of resistance limits transferability of most anticancer therapies into curative treatment and understanding mechanisms beyond it remains a big challenge. Many high resolution experimental observations show enormous intratumor…

种群与进化 · 定量生物学 2013-07-03 B. Brutovsky , D. Horvath

Discrimination can occur when the underlying unbiased labels are overwritten by an agent with potential bias, resulting in biased datasets that unfairly harm specific groups and cause classifiers to inherit these biases. In this paper, we…

机器学习 · 计算机科学 2023-12-27 Yixuan Zhang , Boyu Li , Zenan Ling , Feng Zhou

This paper introduces a novel decomposition framework to explain heterogeneity in causal effects observed across different studies, considering both observational and randomized settings. We present a formal decomposition of between-study…

统计方法学 · 统计学 2025-12-18 Brian Gilbert , Ivan Dıaz , Kara E. Rudolph , Nicholas Williams , Tat-Thang Vo

In heterogeneous cohorts and those where censoring by non-primary risks is informative many conventional survival analysis methods are not applicable; the proportional hazards assumption is usually violated at population level and the…

Meta-analysis is a powerful tool for assessing drug safety by combining treatment-related toxicological findings across multiple studies, as clinical trials are typically underpowered for detecting adverse drug effects. However, incomplete…

统计方法学 · 统计学 2024-02-12 Xinyue Qi , Shouhao Zhou , Christine B. Peterson , Yucai Wang , Xinying Fang , Michael L. Wang , Chan Shen

The main objective of this study is to quantify how different policy-sensitive factors are associated with risk of motorcycle injury crashes, while controlling for rider-specific, psycho-physiological, and other observed/unobserved factors.…

应用统计 · 统计学 2018-08-22 Behram Wali , Asad Khattak , Aemal Khattak

Treatment effect heterogeneity occurs when individual characteristics influence the effect of a treatment. We propose a novel approach that combines prognostic score matching and conditional inference trees to characterize effect…

Interval-censored competing risks data arise when each study subject may experience an event or failure from one of several causes and the failure time is not observed exactly but rather known to lie in an interval between two successive…

统计方法学 · 统计学 2016-03-02 Lu Mao , D. Y. Lin , Donglin Zeng

Restricting randomization in the design of experiments (e.g., using blocking/stratification, pair-wise matching, or rerandomization) can improve the treatment-control balance on important covariates and therefore improve the estimation of…

计量经济学 · 经济学 2020-11-02 Brian Quistorff , Gentry Johnson

Adjusting for latent covariates is crucial for estimating causal effects from observational textual data. Most existing methods only account for confounding covariates that affect both treatment and outcome, potentially leading to biased…

计算与语言 · 计算机科学 2023-11-27 Yuxiang Zhou , Yulan He

In recent years, machine learning algorithms have become ubiquitous in a multitude of high-stakes decision-making applications. The unparalleled ability of machine learning algorithms to learn patterns from data also enables them to…

机器学习 · 计算机科学 2022-07-14 José Pombal , André F. Cruz , João Bravo , Pedro Saleiro , Mário A. T. Figueiredo , Pedro Bizarro

Studies often estimate associations between an outcome and multiple variates. For example, studies of diagnostic test accuracy estimate sensitivity and specificity, and studies of predictive and prognostic factors typically estimate…