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The Luria-Delbr{\"u}ck experiment is a cornerstone of evolutionary theory, demonstrating the randomness of mutations before selection. The distribution of the number of mutants in this experiment has been the subject of intense…

生物物理 · 物理学 2015-07-20 Bahram Houchmandzadeh

Baldwinian and Lamarckian evolution have existed for a long time in evolutionary algorithms (EAs) without ever dominating the academic literature or practical applications. In this work, we use modern empirical and theoretical methods to…

神经与进化计算 · 计算机科学 2026-05-28 Inès Benito , Johannes F. Lutzeyer , Benjamin Doerr

We discuss the evaluation of Luria-Delbrueck fluctuation experiments under Bellman-Harris models of cell proliferation. It is shown that under certain very natural assumptions concerning the life-time distributions and the offspring…

概率论 · 数学 2007-05-23 Wolfgang P. Angerer

The classical Luria-Delbr\"uck model for fluctuation analysis is extended to the case where cells can either divide or die at the end of their generation time. This leads to a family of probability distributions generalizing the…

种群与进化 · 定量生物学 2013-05-30 Bernard Ycart

Originally developed to elucidate the mechanisms of natural selection in bacteria, the Luria-Delbr\"uck model assumed that cells are intrinsically capable of dividing an unlimited number of times. This assumption however, is not true for…

种群与进化 · 定量生物学 2015-11-17 Ignacio A Rodriguez-Brenes , Dominik Wodarz , Natalia L. Komarova

The Luria--Delbr\"uck mutation model is a cornerstone of evolution theory and has been mathematically formulated in a number of ways. In this paper we illustrate how this model of mutation rates can be derived by means of classical…

种群与进化 · 定量生物学 2022-12-02 Lorenzo Pareschi , Giuseppe Toscani

This study explores the integration of Lamarckian system into evolutionary robotics (ER), comparing it with the traditional Darwinian model across various environments. By adopting Lamarckian principles, where robots inherit learned traits,…

机器人学 · 计算机科学 2024-03-29 Jie Luo , Karine Miras , Carlo Longhi , Oliver Weissl , Agoston E. Eiben

Microbial populations adapt to their environment by acquiring advantageous mutations, but in the early twentieth century, questions about how these organisms acquire mutations arose. The experiment of Salvador Luria and Max Delbr\"uck that…

种群与进化 · 定量生物学 2021-06-24 Stephen Montgomery-Smith , Hesam Oveys

Lamarckian inheritance has been shown to be a powerful accelerator in systems where the joint evolution of robot morphologies and controllers is enhanced with individual learning. Its defining advantage lies in the offspring inheriting…

机器人学 · 计算机科学 2026-04-20 Jed R Muff , Karine Miras , A. E. Eiben

Instructive influence of environment on heredity has been a debated topic for centuries. Darwin's identification of natural selection coupled to chance variation as the driving force for evolution, against a formal interpretation proposed…

基因组学 · 定量生物学 2007-05-23 Antoine Danchin

At the fundamental conceptual level, two alternatives have traditionally been considered for how mutations arise and how evolution happens: 1) random mutation and natural selection, and 2) Lamarckism. Recently, the theory of…

神经与进化计算 · 计算机科学 2026-04-15 Liudmyla Vasylenko , Adi Livnat

Dietrich and Haider (2014) justify their integrative framework for creativity founded on evolutionary theory and prediction research on the grounds that "theories and approaches guiding empirical research on creativity have not been…

神经元与认知 · 定量生物学 2016-04-15 Liane Gabora , Stuart Kauffman

The Luria-Delbr\"uck distribution is a classical model of mutations in cell kinetics. It is obtained as a limit when the probability of mutation tends to zero and the number of divisions to infinity. It can be interpreted as a compound…

应用统计 · 统计学 2013-09-11 Agnès Hamon , Bernard Ycart

The Luria-Delbr\"uck mutation model has a long history and has been mathematically formulated in several different ways. Here we tackle the problem in the case of a continuous distribution using some mathematical tools from nonlinear…

数学物理 · 物理学 2011-12-14 Eugene Kashdan , Lorenzo Pareschi

In recent years, studies in epigenetic inheritance in biological systems as well as studies on evolution in non-biological systems e.g., machine learning and robotics, have reopened the discussion of non-Darwinian methods of evolutionary…

适应与自组织系统 · 物理学 2023-05-02 Kristoffer Reinholt Thomsen , Steen Rasmussen

Evolutionary robot systems offer two principal advantages: an advanced way of developing robots through evolutionary optimization and a special research platform to conduct what-if experiments regarding questions about evolution. Our study…

机器人学 · 计算机科学 2023-09-26 Jie Luo , Karine Miras , Jakub Tomczak , Agoston E. Eiben

The Luria-Delbr\"uck model is a classic model of population dynamics with random mutations, that has been used historically to prove that random mutations drive evolution. In typical scenarios, the relevant mutation rate is exceedingly…

生物物理 · 物理学 2024-02-22 Deng Pan , Jie Lin , Ariel Amir

The estimation of mutation probabilities and relative fitnesses in fluctuation analysis is based on the unrealistic hypothesis that the single-cell times to division are exponentially distributed. Using the classical Luria-Delbr\"{u}ck…

定量方法 · 定量生物学 2014-03-05 Bernard Ycart

The paper is devoted to the study of Darwinian evolution in two mathematical models. The first one is a variation on the Malthusian population growth model with Verhulst's environmental capacity. The second model is grounded in the theory…

概率论 · 数学 2025-04-22 Mateusz Krukowski

Current models of animal evolution focus on selection of individuals, ignoring the much faster selection of symbiotic bacteria. Here we take host-symbiont interactions into account by introducing a Population Genetics-like model of…

种群与进化 · 定量生物学 2016-12-28 Dino Osmanovic , David A Kessler , Yitzhak Rabin , Yoav Soen
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