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Researchers in biomedical studies often work with samples that are not selected uniformly at random from the population of interest, a major example being a case-control study. While these designs are motivated by specific scientific…

The recently proposed fixed-X knockoff is a powerful variable selection procedure that controls the false discovery rate (FDR) in any finite-sample setting, yet its theoretical insights are difficult to show beyond Gaussian linear models.…

统计方法学 · 统计学 2023-11-28 Han Su , Panxu Yuan , Qingyang Sun , Mengxi Yi , Gaorong Li

This paper develops a framework for testing for associations in a possibly high-dimensional linear model where the number of features/variables may far exceed the number of observational units. In this framework, the observations are split…

统计方法学 · 统计学 2018-05-04 Rina Foygel Barber , Emmanuel J. Candes

Knockoffs are a popular statistical framework that addresses the challenging problem of conditional variable selection in high-dimensional settings with statistical control. Such statistical control is essential for the reliability of…

统计方法学 · 统计学 2025-04-30 Alexandre Blain , Angel Reyero Lobo , Julia Linhart , Bertrand Thirion , Pierre Neuvial

Thanks to its fine balance between model flexibility and interpretability, the nonparametric additive model has been widely used, and variable selection for this type of model has been frequently studied. However, none of the existing…

统计方法学 · 统计学 2022-01-10 Xiaowu Dai , Xiang Lyu , Lexin Li

One limitation of the most statistical/machine learning-based variable selection approaches is their inability to control the false selections. A recently introduced framework, model-x knockoffs, provides that to a wide range of models but…

机器学习 · 统计学 2025-09-03 Deniz Koyuncu , Alex Gittens , Bülent Yener

In many fields of science, we observe a response variable together with a large number of potential explanatory variables, and would like to be able to discover which variables are truly associated with the response. At the same time, we…

统计方法学 · 统计学 2015-10-15 Rina Foygel Barber , Emmanuel J. Candès

We propose a novel multiple testing methodology for controlling the false discovery rate (FDR) in high-dimensional linear models that integrates model-X knockoff techniques with debiased penalized regression estimators. At the foundation of…

统计方法学 · 统计学 2026-03-17 Jinyuan Chang , Chenlong Li , Cheng Yong Tang , Zhengtian Zhu

Power and reproducibility are key to enabling refined scientific discoveries in contemporary big data applications with general high-dimensional nonlinear models. In this paper, we provide theoretical foundations on the power and robustness…

统计理论 · 数学 2017-09-04 Yingying Fan , Emre Demirkaya , Gaorong Li , Jinchi Lv

Variable selection properties of procedures utilizing penalized-likelihood estimates is a central topic in the study of high dimensional linear regression problems. Existing literature emphasizes the quality of ranking of the variables by…

This paper develops a method based on model-X knockoffs to find conditional associations that are consistent across diverse environments, controlling the false discovery rate. The motivation for this problem is that large data sets may…

统计方法学 · 统计学 2021-06-09 Shuangning Li , Matteo Sesia , Yaniv Romano , Emmanuel Candès , Chiara Sabatti

We investigate the robustness of the model-X knockoffs framework with respect to the misspecified or estimated feature distribution. We achieve such a goal by theoretically studying the feature selection performance of a practically…

统计方法学 · 统计学 2024-06-06 Yingying Fan , Lan Gao , Jinchi Lv

This paper introduces an innovative method for conducting conditional independence testing in high-dimensional data, facilitating the automated discovery of significant associations within distinct subgroups of a population, all while…

统计方法学 · 统计学 2023-09-19 Matteo Sesia , Tianshu Sun

In this article, we propose a novel strategy for conducting variable selection without prior model topology knowledge using the knockoff method with boosted tree models. Our method is inspired by the original knockoff method, where the…

统计方法学 · 统计学 2020-02-24 Tao Jiang , Yuanyuan Li , Alison A. Motsinger-Reif

A core strength of knockoff methods is their virtually limitless customizability, allowing an analyst to exploit machine learning algorithms and domain knowledge without threatening the method's robust finite-sample false discovery rate…

统计理论 · 数学 2021-07-15 Xiao Li , William Fithian

We propose a unified theoretical framework for studying the robustness of the model-X knockoffs framework by investigating the asymptotic false discovery rate (FDR) control of the practically implemented approximate knockoffs procedure.…

机器学习 · 统计学 2025-02-11 Yingying Fan , Lan Gao , Jinchi Lv , Xiaocong Xu

Barber and Candes recently introduced a feature selection method called knockoff+ that controls the false discovery rate (FDR) among the selected features in the classical linear regression problem. Knockoff+ uses the competition between…

统计方法学 · 统计学 2019-11-25 Kristen Emery , Uri Keich

We address challenges in variable selection with highly correlated data that are frequently present in finance, economics, but also in complex natural systems as e.g. weather. We develop a robustified version of the knockoff framework,…

计量经济学 · 经济学 2022-06-14 Konstantin Görgen , Abdolreza Nazemi , Melanie Schienle

We consider the problem of variable selection in regression models. In particular, we are interested in selecting explanatory covariates linked with the response variable and we want to determine which covariates are relevant, that is which…

统计方法学 · 统计学 2019-07-09 Anne Gégout-Petit , Aurélie Gueudin-Muller , Clémence Karmann

We introduce local conditional hypotheses that express how the relation between explanatory variables and outcomes changes across different contexts, described by covariates. By expanding upon the model-X knockoff filter, we show how to…

统计方法学 · 统计学 2026-01-12 Paula Gablenz , Matteo Sesia , Tianshu Sun , Chiara Sabatti