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相关论文: Individual Treatment Effect Prediction for ALS Pat…

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Single-subject health data are becoming increasingly available thanks to advances in self-tracking technology (e.g., wearable devices, mobile apps, sensors, implants). Many users and health caregivers seek to use such observational time…

应用统计 · 统计学 2019-01-23 Eric Jay Daza

Randomized experiments have been used to assist decision-making in many areas. They help people select the optimal treatment for the test population with certain statistical guarantee. However, subjects can show significant heterogeneity in…

人工智能 · 计算机科学 2017-05-25 Yan Zhao , Xiao Fang , David Simchi-Levi

Personalized medicine has received increasing attention among statisticians, computer scientists, and clinical practitioners. A major component of personalized medicine is the estimation of individualized treatment rules (ITRs). Recently,…

统计方法学 · 统计学 2015-08-14 Xin Zhou , Nicole Mayer-Hamblett , Umer Khan , Michael R. Kosorok

We address a core problem in causal inference: estimating heterogeneous treatment effects using panel data with general treatment patterns. Many existing methods either do not utilize the potential underlying structure in panel data or have…

机器学习 · 统计学 2024-06-11 Retsef Levi , Elisabeth Paulson , Georgia Perakis , Emily Zhang

Because many illnesses show heterogeneous response to treatment, there is increasing interest in individualizing treatment to patients [Arch. Gen. Psychiatry 66 (2009) 128--133]. An individualized treatment rule is a decision rule that…

统计理论 · 数学 2011-05-18 Min Qian , Susan A. Murphy

Automatic prediction of amyotrophic lateral sclerosis (ALS) disease progression provides a more efficient and objective alternative than manual approaches. We propose ALS longitudinal speech transformer (ALST), a neural network-based…

The identification of heterogeneous treatment effects (HTE) across subgroups is of significant interest in clinical trial analysis. Several state-of-the-art HTE estimation methods, including causal forests, apply recursive partitioning for…

统计方法学 · 统计学 2025-06-10 Vik Shirvaikar , Andrea Storås , Xi Lin , Chris Holmes

In the fight against hard-to-treat diseases such as cancer, it is often difficult to discover new treatments that benefit all subjects. For regulatory agency approval, it is more practical to identify subgroups of subjects for whom the…

统计方法学 · 统计学 2014-10-09 Wei-Yin Loh , Xu He , Michael Man

The Predictive Approaches to Treatment Effect Heterogeneity statement focused on baseline risk as a robust predictor of treatment effect and provided guidance on risk-based assessment of treatment effect heterogeneity in the RCT setting.…

Estimating treatment effects from observational data is of central interest across numerous application domains. Individual treatment effect offers the most granular measure of treatment effect on an individual level, and is the most useful…

机器学习 · 统计学 2024-08-06 Hengrui Cai , Huaqing Jin , Lexin Li

Estimation of heterogeneous treatment effects (HTE) is of prime importance in many disciplines, ranging from personalized medicine to economics among many others. Random forests have been shown to be a flexible and powerful approach to HTE…

统计方法学 · 统计学 2025-10-07 Susanne Dandl , Torsten Hothorn , Heidi Seibold , Erik Sverdrup , Stefan Wager , Achim Zeileis

Randomized experiments have been the gold standard for drawing causal inference. The conventional model-based approach has been one of the most popular ways for analyzing treatment effects from randomized experiments, which is often carried…

统计方法学 · 统计学 2024-11-19 Tianyi Qu , Jiangchuan Du , Xinran Li

Identifying patients who benefit from a treatment is a key aspect of personalized medicine, which allows the development of individualized treatment rules (ITRs). Many machine learning methods have been proposed to create such rules.…

Individualized treatment rules (ITR) can improve health outcomes by recognizing that patients may respond differently to treatment and assigning therapy with the most desirable predicted outcome for each individual. Flexible and efficient…

统计方法学 · 统计学 2017-09-25 Brent R. Logan , Rodney Sparapani , Robert E. McCulloch , Purushottam W. Laud

In this paper, we outline a principled approach to estimate an individualized treatment rule that is appropriate for data from observational studies where, in addition to treatment assignment not being independent of individual…

统计方法学 · 统计学 2019-06-05 Jeremy Roth , Noah Simon

The inclusion of the propensity score as a covariate in Bayesian regression trees for causal inference can reduce the bias in treatment effect estimations, which occurs due to the regularization-induced confounding phenomenon. This study…

统计方法学 · 统计学 2018-08-30 Pedro Henrique Filipini dos Santos , Hedibert Freitas Lopes

Many estimators of the average effect of a treatment on an outcome require estimation of the propensity score, the outcome regression, or both. It is often beneficial to utilize flexible techniques such as semiparametric regression or…

统计方法学 · 统计学 2019-05-14 Cheng Ju , David Benkeser , Mark J. van der Laan

In this paper, we propose a data-adaptive empirical likelihood-based approach for treatment effect estimation and inference, which overcomes the obstacle of the traditional empirical likelihood-based approaches in the high-dimensional…

统计方法学 · 统计学 2020-12-15 Wei Liang , Ying Yan

Uplift modeling is crucial in various applications ranging from marketing and policy-making to personalized recommendations. The main objective is to learn optimal treatment allocations for a heterogeneous population. A primary line of…

统计方法学 · 统计学 2023-12-20 Preetam Nandy , Xiufan Yu , Wanjun Liu , Ye Tu , Kinjal Basu , Shaunak Chatterjee

Individualizing treatment assignment can improve outcomes for diseases with patient-to-patient variability in comparative treatment effects. When a clinical trial demonstrates that some patients improve on treatment while others do not, it…

统计方法学 · 统计学 2022-11-02 Nina Galanter , Marco Carone , Ronald C. Kessler , Alex Luedtke