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Common models for two-phase lipid bilayer membranes are based on an energy that consists of an elastic term for each lipid phase and a line energy at interfaces. Although such an energy controls only the length of interfaces, the membrane…

偏微分方程分析 · 数学 2016-03-10 Michael Helmers

A model of lipid bilayers made of a mixture of two lipids with different average compositions on both leaflets, is developed. A Landau hamiltonian describing the lipid-lipid interactions on each leaflet, with two lipidic fields $\psi_1$ and…

软凝聚态物质 · 物理学 2014-08-28 Guillaume Gueguen , Nicolas Destainville , Manoel Manghi

We propose a model that accounts for budding behavior of domains in lipid bilayers, where each of the bilayer leaflets has a coupling between its local curvature and local lipid composition. The compositional asymmetry between the two…

软凝聚态物质 · 物理学 2015-03-31 Jean Wolff , Shigeyuki Komura , David Andelman

An elastic bilayer, consisting of an equibiaxially pre-stretched sheet bonded to a stress-free one, spontaneously morphs into curved shapes in the absence of external loads or constraints. Using experiments and numerical simulations, we…

软凝聚态物质 · 物理学 2018-11-28 Noè Caruso , Aleksandar Cvetković , Alessandro Lucantonio , Giovanni Noselli , Antonio DeSimone

We present Monte Carlo simulations of an ultra coarse-grained lipid bilayer with different number of lipids on both leaflets. In the simulations, we employ a new method for measuring the elastic parameters of the membrane, including the…

软凝聚态物质 · 物理学 2025-05-20 Oded Farago

The electrostatic contribution to spontaneous membrane curvature is calculated within Poisson-Boltzmann theory under a variety of assumptions and emphasizing parameters in the physiological range. Asymmetric surface charges, either fixed…

凝聚态物理 · 物理学 2009-10-28 Tom Chou , Marko V. Jaric' , Eric D. Siggia

Cellular membranes are elastic lipid bilayers that contain a variety of proteins, including ion channels, receptors, and scaffolding proteins. These proteins are known to diffuse in the plane of the membrane and to influence the bending of…

软凝聚态物质 · 物理学 2020-10-28 Arijit Mahapatra , David Saintillan , Padmini Rangamani

A cell membrane can be simply regarded as composite material consisting of lipid bilayer, membrane cytoskeleton beneath lipid bilayer, and proteins embedded in lipid bilayer and linked with membrane cytoskeleton if one only concerns its…

其他定量生物学 · 定量生物学 2007-06-26 Z. C. Tu , R. An , Z. C. Ou-Yang

We investigate how an externally imposed curvature influences lipid segregation on two-phase-coexistent membranes. We show that the bending-modulus contrast of the two phases and the curvature act together to yield a reduced effective line…

软凝聚态物质 · 物理学 2018-06-21 Fangfu Ye , Robin L. B. Selinger , Jonathan V. Selinger

We present a model for the efficient simulation of generic bilayer membranes. Individual lipids are represented by one head- and two tail-beads. By means of simple pair potentials these robustly self-assemble to a fluid bilayer state over a…

软凝聚态物质 · 物理学 2009-11-11 Ira R. Cooke , Kurt Kremer , Markus Deserno

Curvature in biological membranes can be generated by a variety of different molecular mechanisms such as protein scaffolding, lipid or protein asymmetry, cytoskeletal forces, etc. These mechanisms have the net effect of generating stresses…

We study stationary points of the bending energy of curves $\gamma\colon[a,b]\to\mathbb{R}^n$ subject to constraints on the arc-length and the curve's holonomy while simultaneously allowing for a variable bending stiffness along the…

微分几何 · 数学 2025-08-05 Oliver Gross , Ulrich Pinkall , Moritz Wahl

We study closed liquid membranes that segregate into three phases due to differences in the chemical and physical properties of its components. The shape and in-plane membrane arrangement of the phases are coupled through phase-specific…

软凝聚态物质 · 物理学 2012-08-17 Matthew F. Demers , Rastko Sknepnek , Monica Olvera de la Cruz

Morphological change of bilayer membrane in vivo is not a spontaneous procedure but modulated by various types of proteins in general. Most of these modulations are associated with the localization of related proteins in the crowded lipid…

定量方法 · 定量生物学 2016-06-30 Michael Mikucki , Y. C. Zhou

This paper is devoted to classical variational problems for planar elastic curves of clamped endpoints, so-called Euler's elastica problem. We investigate a straightening limit that means enlarging the distance of the endpoints, and obtain…

经典分析与常微分方程 · 数学 2020-10-15 Tatsuya Miura

The Canham--Helfrich free-energy density for a lipid bilayer has drawn considerable attention. Aside from the mean and Gaussian curvatures, this free-energy density involves a spontaneous mean-curvature that encompasses information…

生物物理 · 物理学 2013-01-22 Brian Seguin , Eliot Fried

We preset a computational study of bending models for the curvature elasticity of lipid bilayer membranes that are relevant for simulations of vesicles and red blood cells. We compute bending energy and forces on triangulated meshes and…

计算工程、金融与科学 · 计算机科学 2020-01-08 Xin Bian , Sergey Litvinov , Petros Koumoutsakos

Induced by proteins within the cell membrane or by differential growth, heating, or swelling, spontaneous curvatures can drastically affect the morphology of thin bodies and induce mechanical instabilities. Yet, the interaction of…

软凝聚态物质 · 物理学 2018-01-31 Matteo Pezzulla , Norbert Stoop , Mark P. Steranka , Abdikhalaq J. Bade , Douglas P. Holmes

Motivated by recent experimental work on multicomponent lipid membranes supported by colloidal scaffolds, we report an exhaustive theoretical investigation of the equilibrium configurations of binary mixtures on curved substrates. Starting…

软凝聚态物质 · 物理学 2018-09-12 Piermarco Fonda , Melissa Rinaldin , Daniela J. Kraft , Luca Giomi

In this work, we study a phase-field model for curvature-driven pattern formation in biomembranes. The model is derived as a gradient flow of an energy functional that approximates the two-phase Canham--Helfrich energy. This leads to a…

偏微分方程分析 · 数学 2025-11-27 Patrik Knopf , Anastasija Pešić , Dennis Trautwein
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