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Light sheet fluorescence microscopy provides optical sectioning and is widely used in volumetric imaging of large specimens. However, the axial resolution and the lateral Field of View (FoV) of the system, defined by the light sheet,…

光学 · 物理学 2021-06-16 Hongjin Li , Zihan Wu , Zhichao Yang , Karl Zhanghao , Peng Xi , Dayong Jin

3D super-resolution fluorescence microscopy typically requires sophisticated setups, sample preparation, or long measurements. A notable exception, SOFI, only requires recording a sequence of frames and no hardware modifications whatsoever…

光学 · 物理学 2024-03-01 Pawel Szczypkowski , Monika Pawlowska , Radek Lapkiewicz

Photobleaching is a major limitation of superresolution Stimulated Depletion Emission (STED) microscopy. Fast scanning has long been considered an effective means to reduce photobleaching in fluorescence microscopy, but a careful…

生物物理 · 物理学 2015-10-07 Yong Wu , Xundong Wu , Rong Lu , Jin Zhang , Ligia Toro , Enrico Stefani

With recent developments in microscopy, such as stimulated emission depletion (STED) microscopy, far-field imaging at resolutions better than the diffraction limit is now a commercially available technique. Here, we show that, in the…

光学 · 物理学 2012-05-29 Chris J. Lee , Klaus J. Boller

In this work we present a modification to conventional X-rays fluorescence using electrons as excitation source, and compare it with the traditional X-ray excitation for the study of pigments. For this purpose we have constructed a…

仪器与探测器 · 物理学 2016-08-24 F. Valle Brozas , A. Crego , L. Roso , A. Peralta Conde

Evanescent-wave microscopy achieves sub-diffraction axial sectioning by confining fluorescence excitation to a thin layer close to the cell/substrate interface. How thin this light sheet exactly is, however, is often unknown. Particularly…

生物物理 · 物理学 2013-02-08 Maia Brunstein , Maxime Teremetz , Christophe Tourain , Martin Oheim

Recent observations of reflected propagating and standing slow-mode waves in hot flaring coronal loops have spurred our investigation into their underlying excitation and damping mechanisms. To understand these processes, we conduct 2.5D…

太阳与恒星天体物理 · 物理学 2024-04-01 Tongjiang Wang , Leon Ofman , Stephen J. Bradshaw

Fluorescent observation of cells generally suffers from the limited axial resolution due to the elongated point spread function of the microscope optics. Consequently, three-dimensional imaging results in axial resolution being several…

Infrared optical measurement has a wide range of applications in industry and science, but infrared light detectors suffer from high costs and inferior performance than visible light detectors. Four-wave mixing (FWM) process allows…

Light-sheet microscopy (LSM) is a powerful imaging technique that uses a planar illumination oriented orthogonally to the detection axis. Two-photon (2P) LSM is a variant of LSM that exploits the 2P absorption effect for sample excitation.…

The OpenFlexure Microscope is a 3D printed, low-cost microscope capable of automated image acquisition through the use of a motorised translation stage and a Raspberry Pi imaging system. This automation has applications in research and…

仪器与探测器 · 物理学 2021-09-16 Joe Knapper , Joel T. Collins , Julian Stirling , Samuel McDermott , William Wadsworth , Richard Bowman

We propose a new design for a multi-color, parallelized STED microscope, capable of multiple beam scanning. Our design is based on a common programmable diffracting optical element used to split, shape, and align both the excitation beams…

光学 · 物理学 2015-04-21 Omer Wagner , Ori Cheshnovsky , Yael Roichman

Several matrix approaches were developed to control light propagation through multiple scattering media under illumination of ultrashort pulses of light. These matrices can be recorded either with spectral or temporal resolution. Thanks to…

光学 · 物理学 2018-06-08 Mickael Mounaix , Duc Minh Ta , Sylvain Gigan

Fluorescence imaging is an essential diagnostic tool in many fields, but diffraction-limited optical imaging at depth is limited by scattering. Here, we present a method based on multiple random illuminations, combined with a computational…

光学 · 物理学 2026-03-30 Lei Zhu , Tengfei Wu , Bernhard Rauer , Hilton B. de Aguiar , Sylvain Gigan

Single dye molecules at cryogenic temperatures display many spectroscopic phenomena known from free atoms and are thus promising candidates for fundamental quantum optical studies. However, the existing techniques for the detection of…

量子物理 · 物理学 2008-02-12 Gert Wrigge , Ilja Gerhardt , Jaesuk Hwang , Gert Zumofen , Vahid Sandoghdar

Fluorescence microscopy is a critical tool across various disciplines, from materials science to biomedical research, yet it is limited by the diffraction limit of resolution. Advanced super-resolution techniques such as localization…

Using optical speckle scanning microscopy [1], we demonstrate that clear images of multiple cells can be obtained through biological scattering tissue, with subcellular resolution and good image quality, as long as the size of the imaging…

光学 · 物理学 2023-07-19 Xin Yang , Ye Pu , Demetri Psaltis

Stimulated amplification of fluorescence signals is obtained under conditions which approach biocompatibility by adding NanoParticles (NPs) to an aqueous solution of fluorescein. The conditions for the stability of the suspension and…

生物物理 · 物理学 2023-10-05 S. Bonnefond , J. Cazareth , S. Abelanet , A. Reynaud , M. Vassalli , F. Brau , G. L. Lippi

We propose an experimental arrangement to image, with attosecond resolution, transient surface plasmonic excitations. The required modifications to state-of-the-art setups used for attosecond streaking experiments from solid surfaces only…

光学 · 物理学 2015-06-18 Mattia Lupetti , Julia Hengster , Thorsten Uphues , Armin Scrinzi

The problem of standing wave formation by superposing two counter-propagating whistler waves in an overdense plasma, studied recently by Sano et al. (Phys. Rev. E 100, 053205 (2019) and Phys. Rev. E 101, 013206 (2020)), has been revisited…

等离子体物理 · 物理学 2021-10-27 Mithun Karmakar , Sudip Sengupta , Bhavesh Patel