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There is increasing interest in learning a set of small outcome-relevant subgraphs in network-predictor regression. The extracted signal subgraphs can greatly improve the interpretation of the association between the network predictor and…

统计方法学 · 统计学 2019-03-27 Lu Wang , Zhengwu Zhang , David Dunson

Link prediction is one of the fundamental problems in network analysis. In many applications, notably in genetics, a partially observed network may not contain any negative examples of absent edges, which creates a difficulty for many…

机器学习 · 统计学 2013-01-30 Yunpeng Zhao , Elizaveta Levina , Ji Zhu

One of the primary goals of systems neuroscience is to relate the structure of neural circuits to their function, yet patterns of connectivity are difficult to establish when recording from large populations in behaving organisms. Many…

机器学习 · 计算机科学 2020-12-08 Anne Draelos , Eva A. Naumann , John M. Pearson

In recent years, it has become common practice in neuroscience to use networks to summarize relational information in a set of measurements, typically assumed to be reflective of either functional or structural relationships between regions…

应用统计 · 统计学 2017-03-20 Cedric E. Ginestet , Jun Li , Prakash Balachandran , Steven Rosenberg , Eric D. Kolaczyk

Miniaturized calcium imaging is an emerging neural recording technique that has been widely used for monitoring neural activity on a large scale at a specific brain region of rats or mice. Most existing calcium-image analysis pipelines…

图像与视频处理 · 电气工程与系统科学 2023-04-18 Zhe Chen , Garrett J. Blair , Chengdi Cao , Jim Zhou , Daniel Aharoni , Peyman Golshani , Hugh T. Blair , Jason Cong

This work presents an unsupervised and semi-automatic image segmentation approach where we formulate the segmentation as a inference problem based on unary and pairwise assignment probabilities computed using low-level image cues. The…

计算机视觉与模式识别 · 计算机科学 2023-05-16 Ayelet Heimowitz , Yosi Keller

The continuous integration of experimental data into coherent models of the brain is an increasing challenge of modern neuroscience. Such models provide a bridge between structure and activity, and identify the mechanisms giving rise to…

神经元与认知 · 定量生物学 2017-03-03 Jannis Schuecker , Maximilian Schmidt , Sacha J. van Albada , Markus Diesmann , Moritz Helias

Electron microscopic connectomics is an ambitious research direction with the goal of studying comprehensive brain connectivity maps by using high-throughput, nano-scale microscopy. One of the main challenges in connectomics research is…

计算机视觉与模式识别 · 计算机科学 2021-04-14 Tran Minh Quan , David G. C. Hildebrand , Won-Ki Jeong

We present an inference method utilizing artificial neural networks for parameter estimation of a quantum probe monitored through a single continuous measurement. Unlike existing approaches focusing on the diffusive signals generated by…

Inferring the connectivity of neural circuits from incomplete observations is a fundamental challenge in neuroscience. We present a covariance-based method for estimating the weight matrix of a recurrent neural network from sparse, partial…

定量方法 · 定量生物学 2026-03-20 Quilee Simeon

Modeling the behavior of coupled networks is challenging due to their intricate dynamics. For example in neuroscience, it is of critical importance to understand the relationship between the functional neural processes and anatomical…

机器学习 · 计算机科学 2021-04-20 Hongyuan You , Sikun Lin , Ambuj K. Singh

Inferring a binary connectivity graph from resting-state fMRI data for a single subject requires making several methodological choices and assumptions that can significantly affect the results. In this study, we investigate the robustness…

统计方法学 · 统计学 2025-03-20 Alice Chevaux , Ali Fahkar , Kévin Polisano , Irène Gannaz , Sophie Achard

The anatomical structure of the brain can be observed via non-invasive techniques such as diffusion imaging. However, these are imperfect because they miss connections that are actually known to exist, especially long range…

神经元与认知 · 定量生物学 2015-02-25 Somwrita Sarkar , Sanjay Chawla , Donna Xu

The field of connectomics faces unprecedented "big data" challenges. To reconstruct neuronal connectivity, automated pixel-level segmentation is required for petabytes of streaming electron microscopy data. Existing algorithms provide…

In this paper we study a linear inverse problem with a biological interpretation, which is modeled by a Fredholm integral equation of the first kind. When the kernel in the Fredholm equation is represented by step func- tions, we obtain…

最优化与控制 · 数学 2013-04-11 C. Conca , R. Lecaros , J. H. Ortega , L. Rosier

Brain connectivity analysis is now at the foreground of neuroscience research. A connectivity network is characterized by a graph, where nodes represent neural elements such as neurons and brain regions, and links represent statistical…

统计方法学 · 统计学 2015-11-04 Yin Xia , Lexin Li

Researchers in the field of connectomics are working to reconstruct a map of neural connections in the brain in order to understand at a fundamental level how the brain processes information. Constructing this wiring diagram is done by…

There is no consensus on how to construct structural brain networks from diffusion MRI. How variations in pre-processing steps affect network reliability and its ability to distinguish subjects remains opaque. In this work, we address this…

In this work, we study the extent to which structural connectomes and topological derivative measures are unique to individual changes within human brains. To do so, we classify structural connectome pairs from two large longitudinal…

神经元与认知 · 定量生物学 2017-02-01 Dmitry Petrov , Boris Gutman , Alexander Ivanov , Joshua Faskowitz , Neda Jahanshad , Mikhail Belyaev , Paul Thompson

We give an information-theoretic interpretation of Canonical Correlation Analysis (CCA) via (relaxed) Wyner's common information. CCA permits to extract from two high-dimensional data sets low-dimensional descriptions (features) that…

信息论 · 计算机科学 2020-03-02 Michael Gastpar , Erixhen Sula