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During tissue development, patterns of gene expression determine the spatial arrangement of cell types. In many cases, gradients of secreted signaling molecules - morphogens - guide this process. The continuous positional information…

分子网络 · 定量生物学 2017-02-08 Ruben Perez-Carrasco , Pilar Guerrero , James Briscoe , Karen Page

Humans and other organisms make decisions choosing between different options, with the aim to maximize the reward and minimize the cost. The main theoretical framework for modeling the decision-making process has been based on the highly…

神经元与认知 · 定量生物学 2024-11-19 Olga Tapinova , Tal Finkelman , Tamar Reitich-Stolero , Rony Paz , Assaf Tal , Nir S. Gov

In Valence Change Memory (VCM) cells, the conductance of an insulating switching layer is reversibly modulated by creating and redistributing point defects under an external field. Accurate simulations of the switching dynamics of these…

无序系统与神经网络 · 物理学 2023-01-02 Manasa Kaniselvan , Mathieu Luisier , Marko Mladenović

The electronic conduction of a novel, three-terminal molecular architecture, analogous to a heterojunction bipolar transistor is studied. In this architecture, two diode arms consisting of donor-acceptor molecular wires fuse through a ring,…

介观与纳米尺度物理 · 物理学 2009-11-13 Haiying He , Ravindra Pandey , Shashi P. Karna

Travelling waves of neural firing activity are observed in brain tissue as a part of various sensory, motor and cognitive processes. They represent an object of major interest in the study of excitable networks, with analysis conducted in…

神经元与认知 · 定量生物学 2025-11-10 Henry D. J. Kerr , Peter Ashwin , Kyle C. A. Wedgwood

In this paper, we study pairs of oscillators that are indirectly coupled via active (excitable) cells. We introduce a scalar phase model for coupled oscillators and excitable cells. We first show that one excitable and one oscillatory cell…

动力系统 · 数学 2019-06-05 Derek Orr , Bard Ermentrout

We have varied the disorder in a two-dimensional electron system in silicon by applying substrate bias. When the disorder becomes sufficiently low, we observe the emergence of the metallic phase, and find evidence for a metal-insulator…

强关联电子 · 物理学 2009-10-30 Dragana Popovic , A. B. Fowler , S. Washburn

Cell crawling on flat substrates is based on intracellular flows of the actin cytoskeleton that are driven by both actin polymerization at the front and myosin contractility at the back. The new experimental tool of optogenetics makes it…

亚细胞过程 · 定量生物学 2023-07-04 Oliver M. Drozdowski , Falko Ziebert , Ulrich S. Schwarz

Mechanistic interpretability has transformed the analysis of transformer circuits by decomposing model behavior into competing algorithms, identifying phase transitions during training, and deriving closed-form predictions for when and why…

机器学习 · 计算机科学 2026-03-19 Alma Lago

Oscillatory activities are widely observed in specific frequency bands of recorded field potentials in different brain regions, and play critical roles in processing neural information. Understanding the structure of these oscillatory…

神经元与认知 · 定量生物学 2015-07-23 Pengsheng Zheng

This paper presents a methodology of controlling the resonance energy exchange in mechanical system consisting of two weakly coupled magnetic pendulums interacting with the magnetic field generated by coils placed underneath. It is shown…

系统与控制 · 电气工程与系统科学 2023-04-20 Valery N. Pilipchuk , Krystian Polczyński , Maksymilian Bednarek , Jan Awrejcewicz

We use the qualitative insight of a planar neuronal phase portrait to detect an excitability switch in arbitrary conductance-based models from a simple mathematical condition. The condition expresses a balance between ion channels that…

神经元与认知 · 定量生物学 2015-06-11 Alessio Franci , Guillaume Drion , Vincent Seutin , Rodolphe Sepulchre

We analyse biased ensembles of trajectories for the random-field Ising model on a fully-connected lattice, which is described exactly by mean-field theory. By coupling the activity of the system to a dynamical biasing field, we find a range…

统计力学 · 物理学 2021-10-27 Jules Guioth , Robert L. Jack

We present an approach for constructing dynamic models for the simulation of gene regulatory networks from simple computational elements. Each element is called a ``gene gate'' and defines an input/output-relationship corresponding to the…

分子网络 · 定量生物学 2007-10-09 R. Blossey , L. Cardelli , A. Phillips

In our previous work, we proposed a novel neuron model based on symmetric differential equations and demonstrated its potential as an efficient signal propagator. Building upon that foundation, the present study delves deeper into the…

神经与进化计算 · 计算机科学 2025-08-01 Kun Jiang

We consider a general class of translation-invariant systems with a specific category of output nonlinearities motivated by biological sensing. We show that no dynamic output feedback can stabilize this class of systems to an isolated…

系统与控制 · 电气工程与系统科学 2025-02-21 Debojyoti Biswas , Eduardo D. Sontag , Noah J. Cowan

The present habilitation thesis in theoretical biological physics addresses two central dynamical processes in cells and organisms: (i) active motility and motility control and (ii) self-organized pattern formation. The unifying theme is…

细胞行为 · 定量生物学 2018-03-21 Benjamin M. Friedrich

Power transistors such as IGBTs and MOSFETs are a source of electromagnetic interference (EMI) during switching due to rapid voltage/current variations. Increasing the switching time can reduce the generation of EMI but increases losses.…

系统与控制 · 电气工程与系统科学 2023-07-28 Daniel Sting Martinez-Padron , Nicolas Patin , Eric Monmasson

Oscillatory activity is ubiquitous in natural and engineered network systems. The interaction scheme underlying interdependent oscillatory components governs the emergence of network-wide patterns of synchrony that regulate and enable…

适应与自组织系统 · 物理学 2022-08-12 Tommaso Menara , Giacomo Baggio , Danielle S. Bassett , Fabio Pasqualetti

The possibility of electron beam guiding is theoretically explored on the surface of a topological insulator through the proximity interaction with a magnetic material. The electronic band modification induced by the exchange coupling at…

介观与纳米尺度物理 · 物理学 2015-06-17 Xiaodong Li , Ki Wook Kim