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Morphological change of bilayer membrane in vivo is not a spontaneous procedure but modulated by various types of proteins in general. Most of these modulations are associated with the localization of related proteins in the crowded lipid…

定量方法 · 定量生物学 2016-06-30 Michael Mikucki , Y. C. Zhou

We consider the lateral diffusion of a protein interacting with the curvature of the membrane. The interaction energy is minimized if the particle is at a membrane position with a certain curvature that agrees with the spontaneous curvature…

软凝聚态物质 · 物理学 2008-12-10 Stefan M. Leitenberger , Ellen Reister-Gottfried , Udo Seifert

The biological function of membranes is closely related to their softness, which is often studied through the membranes' thermally-driven fluctuations. The analysis commonly assumes that the relaxation rate of a pure bending deformation is…

软凝聚态物质 · 物理学 2024-07-09 Hammad A. Faizi , Rony Granek , Petia M. Vlahovska

We consider the hydrodynamics of lipid bilayers containing transmembrane proteins of arbitrary shape. This biologically-motivated problem is relevant to the cell membrane, whose fluctuating dynamics play a key role in phenomena ranging from…

软凝聚态物质 · 物理学 2016-10-10 Andrew Callan-Jones , Marc Durand , Jean-Baptiste Fournier

We theoretically investigate the relaxation dynamics of a nearly-flat binary lipid bilayer membrane by taking into account the membrane tension, hydrodynamics of the surrounding fluid, inter-monolayer friction and mutual diffusion in each…

软凝聚态物质 · 物理学 2016-05-05 Ryuichi Okamoto , Yuichi Kanemori , Shigeyuki Komura , Jean-Baptiste Fournier

Cellular membranes are elastic lipid bilayers that contain a variety of proteins, including ion channels, receptors, and scaffolding proteins. These proteins are known to diffuse in the plane of the membrane and to influence the bending of…

软凝聚态物质 · 物理学 2020-10-28 Arijit Mahapatra , David Saintillan , Padmini Rangamani

The shapes of cell membranes are largely regulated by membrane associated, curvature active, proteins. We use a numerical model of the membrane with elongated membrane inclusions, recently developed by us, which posses spontaneous…

生物物理 · 物理学 2013-02-08 N. Ramakrishnan , P. B. Sunil Kumar , John H. Ipsen

In multicomponent membranes, internal scalar fields may couple to membrane curvature, thus renormalizing the membrane elastic constants and destabilizing the flat membranes. Here, a general elasticity theory of membranes is considered that…

软凝聚态物质 · 物理学 2018-03-07 S. Alex Rautu

Membrane bending is an extensively studied problem from both modeling and experimental perspectives because of the wide implications of curvature generation in cell biology. Many of the curvature generating aspects in membranes can be…

软凝聚态物质 · 物理学 2021-07-21 Arijit Mahapatra , David Saintillan , Padmini Rangamani

We study the linearized hydrodynamics of a two-component fluid membrane near a repulsive wall, via a model which incorporates curvature- concentration coupling as well as hydrodynamic interactions. This model is a simplified version of a…

软凝聚态物质 · 物理学 2009-11-07 Sumithra Sankararaman , Gautam I. Menon , P. B. Sunil Kumar

We use a simple and efficient computer model to investigate the physical properties of bilayer membranes. The amphiphilic molecules are modeled as short rigid trimers with finite range pair interactions between them. The pair potentials…

软凝聚态物质 · 物理学 2009-11-10 Oded Farago

When considering flows in biological membranes, they are usually treated as flat, though more often than not, they are curved surfaces, even extremely curved, as in the case of the endoplasmic reticulum. Here, we study the topological…

流体动力学 · 物理学 2021-05-27 Rickmoy Samanta , Naomi Oppenheimer

There are a great many proteins that localize to and collectively generate curvature in biological fluid membranes. We study changes in the topology of fluid membranes due to the presence of highly anisotropic, curvature-inducing proteins.…

软凝聚态物质 · 物理学 2015-05-19 Kiyotaka Akabori , C. D. Santangelo

Diffusion rates through a membrane can be asymmetric, if the diffusing particles are spatially extended and the pores in the membrane have asymmetric structure. This phenomenon is demonstrated here via a deterministic simulation of a…

统计力学 · 物理学 2007-05-23 Norman Packard , Rob Shaw

We theoretically investigate the thermally-driven curvature and lipid density fluctuations of a quasi-spherical vesicle, accounting for the dissipation due to monolayer viscosity and intermonolayer friction. The theory predicts that…

软凝聚态物质 · 物理学 2026-05-06 Petia M. Vlahovska , Rony Granek

We investigate pores in fluid membranes by molecular dynamics simulations of an amphiphile-solvent mixture, using a molecular coarse-grained model. The amphiphilic membranes self-assemble into a lamellar stack of amphiphilic bilayers…

软凝聚态物质 · 物理学 2009-11-11 Claire Loison , Michel Mareschal , Friederike Schmid

Cellular membranes exhibit a large variety of shapes, strongly coupled to their function. Many biological processes involve dynamic reshaping of membranes, usually mediated by proteins. This interaction works both ways: while proteins…

软凝聚态物质 · 物理学 2018-06-12 Afshin Vahid , Anđela Šarić , Timon Idema

We present a general and systematic theory of non-equilibrium dynamics of multi-component fluid membranes, in general, and membranes containing transmembrane proteins, in particular. Developed based on a minimal number of principles of…

软凝聚态物质 · 物理学 2009-11-10 Michael A. Lomholt , Per L. Hansen , Ling Miao

An integrated mechanical model for fiber-laden membranes is presented and representative predictions of relevance to cellulose ordering and orientation in the plant cell wall are presented. The model describes nematic liquid crystalline…

生物物理 · 物理学 2009-06-24 Y. K. Murugesan , A. D. Rey

Curvature in biological membranes can be generated by a variety of different molecular mechanisms such as protein scaffolding, lipid or protein asymmetry, cytoskeletal forces, etc. These mechanisms have the net effect of generating stresses…

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