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We assess electrical brain dynamics before, during, and after one-hundred human epileptic seizures with different anatomical onset locations by statistical and spectral properties of functionally defined networks. We observe a concave-like…

神经元与认知 · 定量生物学 2013-11-25 Kaspar A. Schindler , Stephan Bialonski , Marie-Therese Horstmann , Christian E. Elger , Klaus Lehnertz

Epilepsy is a neurological disorder identified by sudden and recurrent seizures, which are believed to be accompanied by distinct changes in brain dynamics. Exploring the dynamic changes of brain network states during seizures can pave the…

信号处理 · 电气工程与系统科学 2023-10-06 Atefeh Khoshkhahtinat , Hoda Mohammadzade

Epileptic seizures are characterized by abnormal and excessive neural activity, where cortical network dynamics seem to become unstable. However, most of the time, during seizure-free periods, cortex of epilepsy patients shows perfectly…

神经元与认知 · 定量生物学 2021-04-06 Annika Hagemann , Jens Wilting , Bita Samimizad , Florian Mormann , Viola Priesemann

The brain is a high-dimensional directional network system consisting of many regions as network nodes that influence each other. The directional influence from one region to another is referred to as directional connectivity. Epilepsy is a…

Epileptic seizures are considered as abnormally hypersynchronous neuronal activities of the brain. Do hypersynchronous neuronal activities in a brain region lead to seizure or the hypersynchronous activities take place due to the…

神经元与认知 · 定量生物学 2013-01-08 Kaushik Majumdar , Pradeep D. Prasad , Shailesh Verma

Drug-resistant epilepsy is traditionally characterized by pathologic cortical tissue comprised of seizure-initiating `foci'. These `foci' are thought to be embedded within an epileptic network whose functional architecture dynamically…

神经元与认知 · 定量生物学 2016-02-17 Ankit Khambhati , Brian Litt , Danielle S. Bassett

Purpose: The understanding of brain activity, and in particular events such as epileptic seizures, lies on the characterisation of the dynamics of the neural networks. The theory of non-linear dynamics provides signal analysis techniques…

医学物理 · 物理学 2007-05-23 C. Silva , I. R. Pimentel , A. Andrade , J. P. Foreid , E. Ducla-Soares

Epilepsy is a neurological disorder arising from anomalies of the electrical activity in the brain, affecting about 0.5--0.8\% of the world population. Several studies investigated the relationship between seizures and brainwave…

机器学习 · 计算机科学 2018-01-25 Paolo Detti , Garazi Zabalo Manrique de Lara , Renato Bruni , Marco Pranzo , Francesco Sarnari

Neural network oscillations are a fundamental mechanism for cognition, perception and consciousness. Consequently, perturbations of network activity play an important role in the pathophysiology of brain disorders. When structural…

神经元与认知 · 定量生物学 2016-04-29 Timothée Proix , Fabrice Bartolomei , Maxime Guye , Viktor K. Jirsa

Epileptic seizures are one of the most well-known dysfunctions of the nervous system. During a seizure, a highly synchronized behavior of neural activity is observed that can cause symptoms ranging from mild sensual malfunctions to the…

神经元与认知 · 定量生物学 2011-08-01 Christian Kuehn , Christian Meisel

Recent studies have shown that seizures can spread and terminate across brain areas via a rich diversity of spatiotemporal patterns. In particular, while the location of the seizure onset area is usually in-variant across seizures in a same…

神经元与认知 · 定量生物学 2018-05-09 Timothée Proix , Viktor K. Jirsa , Fabrice Bartolomei , Maxime Guye , Wilson Truccolo

We analyze the connectivity structure of weighted brain networks extracted from spontaneous magnetoencephalographic (MEG) signals of healthy subjects and epileptic patients (suffering from absence seizures) recorded at rest. We find that,…

数据分析、统计与概率 · 物理学 2011-01-21 M. Chavez , M. Valencia , V. Navarro , V. Latora , J. Martinerie

The underlying dynamics for the electroencephalographic (EEG) recordings from humans but especially epilepsy patients are usually not completely known. However, the ictal activity is claimed to be characterized by synchronous oscillations…

生物物理 · 物理学 2010-08-09 Caglar Tuncay

The analysis of the activity of neuronal cultures is considered to be a good proxy of the functional connectivity of in vivo neuronal tissues. Thus, the functional complex network inferred from activity patterns is a promising way to…

神经元与认知 · 定量生物学 2014-09-09 Sara Teller , Clara Granell , Manlio De Domenico , Jordi Soriano , Sergio Gomez , Alex Arenas

Focal epilepsy is a devastating neurological disorder that affects an overwhelming number of patients worldwide, many of whom prove resistant to medication. The efficacy of current innovative technologies for the treatment of these patients…

There is increasing evidence for specific cortical and subcortical large-scale human epileptic networks to be involved in the generation, spread, and termination of not only primary generalized but also focal onset seizures. The complex…

神经元与认知 · 定量生物学 2016-10-07 Christian Geier , Marie-Therese Kuhnert , Christian E. Elger , Klaus Lehnertz

Alterations to structural and functional brain networks have been reported across many neurological conditions. However, the relationship between structure and function -- their coupling -- is relatively unexplored, particularly in the…

The electroencephalographic (EEG) data intracerebrally recorded from 20 epileptic humans with different brain origins of focal epilepsies or types of seizures, ages and sexes are investigated (nearly 700 million data). Multi channel…

生物物理 · 物理学 2010-02-19 Caglar Tuncay

In many realistic networks, the edges representing the interactions between the nodes are time-varying. There is growing evidence that the complex network that models the dynamics of the human brain has time-varying interconnections, i.e.,…

神经元与认知 · 定量生物学 2016-11-29 G Manjunath

Medically uncontrolled epileptic seizures affect nearly 15 million people worldwide, resulting in enormous economic and psychological burdens. Treatment of medically refractory epilepsy is essential for patients to achieve remission,…

定量方法 · 定量生物学 2025-12-25 Yaoyue Wang , Arian Ashourvan , Guilherme Ramos , Paul Bogdan , Emily Pereira
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