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Resistive switching is one of the foremost candidates for building novel types of non-volatile random access memories. Any practical implementation of such a memory cell calls for a strong miniaturization, at which point fluctuations start…

材料科学 · 物理学 2017-10-11 Paul K. Radtke , Andrew L. Hazel , Arthur V. Straube , Lutz Schimansky-Geier

Noise induced excitability is studied in type I and II Morris-Lecar neurons subject to constant sub threshold input, where fluctuations arise from sodium and potassium ion channels. Ion channels open and close randomly, creating current…

细胞行为 · 定量生物学 2014-09-08 Jay Newby

The phase-response curve (PRC) is an important tool to determine the excitability type of single neurons which reveals consequences for their synchronizing properties. We review five methods to compute the PRC from both model data and…

定量方法 · 定量生物学 2010-03-29 Benjamin Torben-Nielsen , Marylka Uusisaari , Klaus M. Stiefel

We consider the reduced dynamics of a molecular chain weakly coupled to a phonon bath. With a small and constant inhomogeneity in the coupling, the excitation relaxation rates are obtained in closed form. They are dominated by transitions…

统计力学 · 物理学 2021-04-16 B. A. Tay

At the level of individual neurons, various coding properties can be inferred from the input-output relationship of a cell. For small inputs, this relation is captured by the phase-response curve (PRC), which measures the effect of a small…

神经元与认知 · 定量生物学 2026-01-14 Janina Hesse , Susanne Schreiber

The highly variable dynamics of neocortical circuits observed in vivo have been hypothesized to represent a signature of ongoing stochastic inference but stand in apparent contrast to the deterministic response of neurons measured in vitro.…

神经元与认知 · 定量生物学 2017-03-14 Mihai A. Petrovici , Johannes Bill , Ilja Bytschok , Johannes Schemmel , Karlheinz Meier

The scaling of transient times to zero-lag synchronization in networks composed of excitable units is shown to be governed by three features of the graph representing the network: the longest path between pairs of neurons (diameter), the…

神经元与认知 · 定量生物学 2015-06-11 H. Brama , Y. Peleg , W. Kinzel , I. Kanter

An electronic circuit device, inspired on the FitzHugh-Nagumo model of neuronal excitability, was constructed and shown to operate with characteristics compatible with those of biological sensory neurons. The nonlinear dynamical model of…

The Hodgkin-Huxley equations constitute one of the more realistic neuronal models in literature and the most accepted one. It is well known that, depending on the value of the external stimuli current, it exhibits periodic solutions, both…

动力系统 · 数学 2015-11-09 A. Balti , V. Lanza , M. A. Aziz-Alaou

The balance between excitation and inhibition is crucial for neuronal computation. It is observed that the balanced state of neuronal networks exists in many experiments, yet its underlying mechanism remains to be fully clarified.…

神经元与认知 · 定量生物学 2017-10-17 Qing-long L. Gu , Songting Li , Wei P. Dai , Douglas Zhou , David Cai

We present a complete mean field theory for a balanced state of a simple model of an orientation hypercolumn. The theory is complemented by a description of a numerical procedure for solving the mean-field equations quantitatively. With our…

神经元与认知 · 定量生物学 2007-05-23 A. Lerchner , G. Sterner , J. Hertz , M. Ahmadi

A bump attractor network is a model that implements a competitive neuronal process emerging from a spike pattern related to an input source. Since the bump network could behave in many ways, this paper explores some critical limits of the…

神经与进化计算 · 计算机科学 2020-03-31 Alberto Arturo Vergani , Christian Robert Huyck

We consider noise-driven exit from a domain of attraction in a two-dimensional bistable system lacking detailed balance. Through analog and digital stochastic simulations, we find a theoretically predicted bifurcation of the most probable…

数据分析、统计与概率 · 物理学 2008-02-03 D. G. Luchinsky , R. S. Maier , R. Mannella , P. V. E. McClintock , D. L. Stein

Voltage-activated ion channels vary randomly between open and closed states, influenced by the membrane potential and other factors. Signal transduction is enhanced by noise in a simple ion channel model. The enhancement occurs in a finite…

生物物理 · 物理学 2007-05-23 Michael J. Barber , Manfred L. Ristig

We examine the effects of stochastic input currents on the firing behavior of two excitable neurons coupled with fast excitatory synapses. In such cells (models), typified by the quadratic integrate and fire model, mutual synaptic coupling…

神经元与认知 · 定量生物学 2007-07-31 Boris S. Gutkin , Juergen Jost , Henry C. Tuckwell

Neuronal systems maintain stable functions despite large variability in their physiological components. Ion channel expression, in particular, is highly variable in neurons exhibiting similar electrophysiological phenotypes, which poses…

神经元与认知 · 定量生物学 2026-05-13 Arthur Fyon , Alessio Franci , Pierre Sacré , Guillaume Drion

Experimental manipulations perturb the neuronal activity. This phenomenon is manifested in the fMRI response. Dynamic causal model and its variants can model these neuronal responses along with the BOLD responses [1, 2, 3, 4, 5] .…

神经元与认知 · 定量生物学 2021-01-15 Sayan Nag

We present a simple analytical tool which gives an approximate insight into the stationary behavior of nonlinear systems undergoing the influence of a weak and rapid noise from one dominating source, e.g. the kinetic equations describing a…

定量方法 · 定量生物学 2008-08-13 Anna Ochab-Marcinek

We consider a continuum model of electrical signals in the human cortex, which takes the form of a system of semilinear, hyperbolic partial differential equations for the inhibitory and excitatory membrane potentials and the synaptic…

神经元与认知 · 定量生物学 2015-06-22 Lennaert van Veen , Kevin Green

Models of neural responses to stimuli with complex spatiotemporal correlation structure often assume that neurons are only selective for a small number of linear projections of a potentially high-dimensional input. Here we explore recent…

神经元与认知 · 定量生物学 2013-06-19 Kanaka Rajan , Olivier Marre , Gašper Tkačik