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The millimeter-long soil-dwelling nematode {\it C. elegans} propels itself by producing undulations that propagate along its body and turns by assuming highly curved shapes. According to our recent study [PLoS ONE \textbf{7}, e40121 (2012)]…

流体动力学 · 物理学 2019-01-18 Alejandro Bilbao , Eligiusz Wajnryb , Siva Vanapalli , Jerzy Blawzdziewicz

Free-living nematode Caenorhabditis elegans is a powerful genetic model, essential for investigations ranging from behavior to neuroscience to aging, and locomotion is a key observable used in these studies. However, despite the fact that…

Organisms move through the world by changing their shape, and here we explore the mapping from shape space to movements in the nematode C. elegans as it crawls on a planar agar surface. We characterize the statistics of the trajectories…

神经元与认知 · 定量生物学 2016-01-05 Greg J Stephens , Bethany Johnson-Kerner , William Bialek , William S Ryu

Undulatory locomotion is common to nematodes as well as to limbless vertebrates, but its control is not understood in spite of the identification of hundred of genes involved in Caenorhabditis elegans locomotion. To reveal the mechanisms of…

神经元与认知 · 定量生物学 2007-06-13 Jan Karbowski , Christopher J. Cronin , Adeline Seah , Jane E. Mendel , Daniel Cleary , Paul W. Sternberg

We investigate how locomotory behavior is generated in the brain focusing on the paradigmatic connectome of nematode Caenorhabditis elegans (C. elegans) and on neuronal activity patterns that control forward locomotion. We map the neuronal…

适应与自组织系统 · 物理学 2020-06-17 Thomas Maertens , Eckehard Schöll , Jorge Ruiz , Philipp Hövel

A major challenge in analyzing animal behavior is to discover some underlying simplicity in complex motor actions. Here we show that the space of shapes adopted by the nematode C. elegans is surprisingly low dimensional, with just four…

其他定量生物学 · 定量生物学 2016-01-05 Greg J Stephens , Bethany Johnson-Kerner , William Bialek , William S Ryu

Animal behaviors are sometimes decomposable into discrete, stereotyped elements. In one model, such behaviors are triggered by specific commands; in the extreme case, the discreteness of behavior is traced to the discreteness of action…

神经元与认知 · 定量生物学 2009-12-31 Greg J. Stephens , William S. Ryu , William Bialek

The nematode Caenorhabditis elegans (C. elegans) serves as an important model organism in a wide variety of biological studies. In this paper we introduce a pipeline for automated analysis of C. elegans imagery for the purpose of studying…

计算机视觉与模式识别 · 计算机科学 2020-05-12 Linfeng Wang , Shu Kong , Zachary Pincus , Charless Fowlkes

Understanding physical rules underlying collective motions requires perturbation of controllable parameters in self-propelled particles. However, controlling parameters in animals is generally not easy, which makes collective behaviours of…

生物物理 · 物理学 2019-01-31 Takuma Sugi , Hiroshi Ito , Masaki Nishimura , Ken H. Nagai

Limbless locomotors, from microscopic worms to macroscopic snakes, traverse complex, heterogeneous natural environments typically using undulatory body wave propagation. Theoretical and robophysical models typically emphasize body…

机器人学 · 计算机科学 2024-02-02 Tianyu Wang , Christopher Pierce , Velin Kojouharov , Baxi Chong , Kelimar Diaz , Hang Lu , Daniel I. Goldman

Undulatory locomotion of microorganisms like soil-dwelling worms and spermatozoa, in structured environments, is ubiquitous in nature. They navigate complex environments consisting of fluids and obstacles, negotiating hydrodynamic effects…

流体动力学 · 物理学 2010-10-20 Trushant S. Majmudar , Eric Keaveny , Mike Shelley , Jun Zhang

Animal behavior is often quantified through subjective, incomplete variables that may mask essential dynamics. Here, we develop a behavioral state space in which the full instantaneous state is smoothly unfolded as a combination of…

神经元与认知 · 定量生物学 2019-12-02 Tosif Ahamed , Antonio Carlos Costa , Greg J. Stephens

We exploit the reduced space of C. elegans postures to develop a novel tracking algorithm which captures both simple shapes and also self-occluding coils, an important, yet unexplored, component of worm behavior. We apply our algorithm to…

定量方法 · 定量生物学 2016-11-01 Onno D Broekmans , Jarlath B Rodgers , William S Ryu , Greg J Stephens

The nematode Caenorhabditis elegans is a well-known model organism used to investigate fundamental questions in biology. Motility assays of this small roundworm are designed to study the relationships between genes and behavior. Commonly,…

计算机视觉与模式识别 · 计算机科学 2015-05-19 Raphael Sznitman , Manaswi Gupta , Gregory D. Hager , Paulo E. Arratia , Josue Sznitman

We experimentally studied the locomotion of the nematode C. elegans in both fluidic and granular media. In this fluid dynamics video, we show the motility gaits of the nematode in these two environments. The motility of the nematode C.…

流体动力学 · 物理学 2011-10-17 X. N. Shen , G. Juarez , P. E. Arratia

We develop a biophysically realistic model of the nematode C. elegans that includes: (i) its muscle structure and activation, (ii) key connectomic activation circuitry, and (iii) a weighted and time-dynamic proprioception. In combination,…

生物物理 · 物理学 2018-03-02 Charles Fieseler , James Kunert-Graf , J. Nathan Kutz

{\it Caenorhabditis elegans} nematode worms are the only animals with the known detailed neural connectivity diagram, well characterized genomics, and relatively simple quantifiable behavioral output. With this in mind, many researchers…

神经元与认知 · 定量生物学 2019-10-17 Jan Karbowski

The physical and bio-mechanical principles that govern undulatory movement on wet surfaces have important applications in physiology, physics, and engineering. The nematode {\it C. elegans}, with its highly stereotypical and functionally…

流体动力学 · 物理学 2015-06-03 Xiao N. Shen , J. Sznitman , P. Krajacic , T. Lamitina , P. E. Arratia

We analyse the neural dynamics and its relation with the emergent behaviour of a robotic vehicle that is controlled by a neural network numerical simulation based on the nervous system of the nematode Caenorhabditis elegans. The robot…

神经元与认知 · 定量生物学 2020-11-19 Carlos E. Valencia Urbina , Sergio A. Cannas , Pablo M. Gleiser

The nematode Caenorhabditis elegans responds to an impressive range of chemical, mechanical and thermal stimuli and is extensively used to investigate the molecular mechanisms that mediate chemosensation, mechanotransduction and…

其他定量生物学 · 定量生物学 2008-02-21 George D. Tsibidis , Nektarios Tavernarakis
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