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The estimation from available data of parameters governing epidemics is a major challenge. In addition to usual issues (data often incomplete and noisy), epidemics of the same nature may be observed in several places or over different…

统计方法学 · 统计学 2021-09-20 Romain Narci , Maud Delattre , Catherine Larédo , Elisabeta Vergu

Persistent homology computes topological invariants from point cloud data. Recent work has focused on developing statistical methods for data analysis in this framework. We show that, in certain models, parametric inference can be performed…

定量方法 · 定量生物学 2014-06-19 Kevin Emmett , Daniel Rosenbloom , Pablo Camara , Raul Rabadan

Shesop is an integrated system to make human lives more easily and to help people in terms of healthcare. Stress and influenza classification is a part of Shesop's application for a healthcare devices such as smartwatch, polar and fitbit.…

计算机与社会 · 计算机科学 2016-07-19 Andrien Ivander Wijaya , Ary Setijadi Prihatmanto , Rifki Wijaya

While drug discovery is vital for human health, the process remains inefficient. Medicinal chemists must navigate a vast protein space to identify target proteins that meet three criteria: physical and functional interactions, therapeutic…

Accurate epidemic forecasting is critical for informing public health decisions and timely interventions. While Physics-Informed Neural Networks have shown promise in various scientific domains, their potential application to real-time…

物理与社会 · 物理学 2026-05-20 Martina Rama , Gabriele Santin , Giulia Cencetti , Michele Tizzoni , Bruno Lepri

Mathematical modeling of biological systems is crucial to effectively and efficiently developing treatments for medical conditions that plague humanity. Often, systems of ordinary differential equations are a traditional tool used to…

经典分析与常微分方程 · 数学 2015-09-01 Eric Jones , Peter Roemer , Mrinal Raghupathi , Stephen Pankavich

We provide a brief technical description of an online platform for disease monitoring, titled as the Flu Detector (fludetector.cs.ucl.ac.uk). Flu Detector, in its current version (v.0.5), uses either Twitter or Google search data in…

人工智能 · 计算机科学 2016-12-19 Vasileios Lampos

Community science observational datasets are useful in epidemiology and ecology for modeling species distributions, but the heterogeneous nature of the data presents significant challenges for standardization, data quality assurance and…

种群与进化 · 定量生物学 2025-12-10 Richard Littauer , Kris Bubendorfer

The cellular adaptive immune response plays a key role in resolving influenza infection. Experiments where individuals are successively infected with different strains within a short timeframe provide insight into the underlying viral…

Strain-level identification of viruses is critical for effective public health responses to potential outbreaks, yet current diagnostic methods often lack the necessary speed or sensitivity. Surface-enhanced Raman spectroscopy (SERS) offers…

Ratios of universal enumerable semimeasures corresponding to hypotheses are investigated as a solution for statistical composite hypotheses testing if an unbounded amount of computation time can be assumed. Influence testing for discrete…

统计理论 · 数学 2009-12-15 Bruno Bauwens

Until now, design of the annual influenza vaccine has relied on phylogenetic or whole-sequence comparisons of the viral coat proteins hemagglutinin and neuraminidase, with vaccine effectiveness assumed to correlate monotonically to the…

生物大分子 · 定量生物学 2007-05-23 Enrique T. Munoz , Michael W. Deem

Influenza remains a significant burden on health systems. Effective responses rely on the timely understanding of the magnitude and the evolution of an outbreak. For monitoring purposes, data on severe cases of influenza in England are…

The Susceptible-Infected-Recovered (SIR) model has successfully mimicked the propagation of such airborne diseases as influenza A (H1N1). Although the SIR model has recently been studied in a multilayer networks configuration, in almost all…

物理与社会 · 物理学 2015-07-16 L. G. Alvarez Zuzek , H. E. Stanley , L. A. Braunstein

This study incorporates mathematical analysis, focusing on developing theories and conducting numerical simulations of Influenza virus transmission using real-world data. The terms in the equations introduce parameters which are determined…

综合数学 · 数学 2024-12-03 Md Kamrujjaman , Kazi Mehedi Mohammad

Despite the recent development of methods dealing with partially observed epidemic dynamics (unobserved model coordinates, discrete and noisy outbreak data), limitations remain in practice, mainly related to the quantity of augmented data…

应用统计 · 统计学 2021-07-26 Romain Narci , Maud Delattre , Catherine Larédo , Elisabeta Vergu

Myriad experiments have identified an important role for $\rm CD8^+$ T cell response mechanisms in determining recovery from influenza A virus infection. Animal models of influenza infection further implicate multiple elements of the immune…

While digital trace data from sources like search engines hold enormous potential for tracking and understanding human behavior, these streams of data lack information about the actual experiences of those individuals generating the data.…

This article reviews quantitative methods to estimate the basic reproduction number of pandemic influenza, a key threshold quantity to help determine the intensity of interventions required to control the disease. Although it is difficult…

种群与进化 · 定量生物学 2009-11-13 Gerardo Chowell , Hiroshi Nishiura

Highly pathogenic avian influenza (HPAI) has expanded its host range with recent detections in dairy cattle, raising critical concerns regarding within-herd persistence and cross-species spillover. This study develops a stochastic…

动力系统 · 数学 2025-12-18 Parul Tiwari , Malavika Smitha , Hammed Olawale Fatoyinbo