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Traditionally, phylogeny and sequence alignment are estimated separately: first estimate a multiple sequence alignment and then infer a phylogeny based on the sequence alignment estimated in the previous step. However, uncertainty in the…

应用统计 · 统计学 2014-11-25 Heejung Shim , Bret Larget

I propose an approach to identify, among several strategies of phylogenetic analysis, those producing the most accurate results. This approach is based on the hypothesis that the more a result is reproduced from independent data, the more…

种群与进化 · 定量生物学 2013-07-08 Blaise Li

Because biological processes can make different loci have different evolutionary histories, species tree estimation requires multiple loci from across the genome. While many processes can result in discord between gene trees and species…

定量方法 · 定量生物学 2018-03-13 Md. Shamsuzzoha Bayzid , Siavash Mirarab , Bastien Boussau , Tandy Warnow

Many asymptotically minimax procedures for function estimation often rely on somewhat arbitrary and restrictive assumptions such as isotropy or spatial homogeneity. This work enhances the theoretical understanding of Bayesian additive…

统计理论 · 数学 2023-12-05 Seonghyun Jeong , Veronika Rockova

Phylogenetic mixtures model the inhomogeneous molecular evolution commonly observed in data. The performance of phylogenetic reconstruction methods where the underlying data is generated by a mixture model has stimulated considerable recent…

种群与进化 · 定量生物学 2007-06-30 Frederick A. Matsen , Mike Steel

Comparative analyses of phylogenetic trees typically require identical taxon sets, however, in practice, trees often include distinct but overlapping taxa. Pruning non-shared leaves discards phylogenetic signal, whereas tree completion can…

种群与进化 · 定量生物学 2026-04-28 Aleksandr Koshkarov , Nadia Tahiri

Many machine learning tools for regression are based on recursive partitioning of the covariate space into smaller regions, where the regression function can be estimated locally. Among these, regression trees and their ensembles have…

统计理论 · 数学 2017-11-30 Stephanie van der Pas , Veronika Rockova

One of the main aims of phylogenetics is the reconstruction of the correct evolutionary tree when data concerning the underlying species set are given. These data typically come in the form of DNA, RNA or protein alignments, which consist…

种群与进化 · 定量生物学 2019-03-22 Mareike Fischer

The reconstruction of phylogenies from DNA or protein sequences is a major task of computational evolutionary biology. Common phenomena, notably variations in mutation rates across genomes and incongruences between gene lineage histories,…

概率论 · 数学 2012-11-30 Elchanan Mossel , Sebastien Roch

Based on decision trees, many fields have arguably made tremendous progress in recent years. In simple words, decision trees use the strategy of "divide-and-conquer" to divide the complex problem on the dependency between input features and…

机器学习 · 计算机科学 2021-01-22 Jinxiong Zhang

The ongoing explosion of genome sequence data is transforming how we reconstruct and understand the histories of biological systems. Across biological scales, from individual cells to populations and species, trees-based models provide a…

种群与进化 · 定量生物学 2025-12-08 Yun Deng , Shing H. Zhan , Yulin Zhang , Chao Zhang , Bingjie Chen

Determining subgroups that respond especially well (or poorly) to specific interventions (medical or policy) requires new supervised learning methods tailored specifically for causal inference. Bayesian Causal Forest (BCF) is a recent…

机器学习 · 统计学 2022-09-16 Nikolay Krantsevich , Jingyu He , P. Richard Hahn

Bayesian inference promises a framework for principled uncertainty quantification of neural network predictions. Barriers to adoption include the difficulty of fully characterizing posterior distributions on network parameters and the…

机器学习 · 统计学 2025-01-22 Katharine Fisher , Youssef Marzouk

Phylogenetic trees play a key role in the reconstruction of evolutionary relationships. Typically, they are derived from aligned sequence data (like DNA, RNA, or proteins) by using optimization criteria like, e.g., maximum parsimony (MP).…

种群与进化 · 定量生物学 2025-06-11 Mirko Wilde , Mareike Fischer

We empirically show that Bayesian inference can be inconsistent under misspecification in simple linear regression problems, both in a model averaging/selection and in a Bayesian ridge regression setting. We use the standard linear model,…

统计理论 · 数学 2018-10-30 Peter Grünwald , Thijs van Ommen

Phylogenetic trees describe the relationships between species in the evolutionary process, and provide information about the rates of diversification. To understand the mechanisms behind macroevolution, we consider a class of multitype…

种群与进化 · 定量生物学 2024-10-07 Mingqi He , Sophie Hautphenne , Yao-ban Chan

Tree ensembles (TEs) find a multitude of practical applications. They represent one of the most general and accurate classes of machine learning methods. While they are typically quite concise in representation, their operation remains…

人工智能 · 计算机科学 2026-04-01 Yacine Izza , Alexey Ignatiev , Xuanxiang Huang , Peter J. Stuckey , Joao Marques-Silva

The remarkable generalization performance of large-scale models has been challenging the conventional wisdom of the statistical learning theory. Although recent theoretical studies have shed light on this behavior in linear models and…

机器学习 · 统计学 2024-06-18 Tomoya Wakayama

For a model of molecular evolution to be useful for phylogenetic inference, the topology of evolutionary trees must be identifiable. That is, from a joint distribution the model predicts, it must be possible to recover the tree parameter.…

种群与进化 · 定量生物学 2011-11-09 Elizabeth S. Allman , John A. Rhodes

Bayesian inference methods rely on numerical algorithms for both model selection and parameter inference. In general, these algorithms require a high computational effort to yield reliable estimates. One of the major challenges in…

定量方法 · 定量生物学 2018-08-09 Patricio Maturana , Brendon J. Brewer , Steffen Klaere , Remco Bouckaert