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Despite significant progress of generative models in the natural sciences, their controllability remains challenging. One fundamentally missing aspect of molecular or protein generative models is an inductive bias that can reflect…

机器学习 · 计算机科学 2023-08-25 Jannis Born , Matteo Manica

In evolutionary studies it is common to use phylogenetic trees to represent the evolutionary history of a set of species. However, in case the transfer of genes or other genetic information between the species or their ancestors has…

组合数学 · 数学 2022-02-15 Katharina T. Huber , Vincent Moulton , Guillaume E. Scholz

Phylogenetic networks generalise phylogenetic trees and allow for the accurate representation of the evolutionary history of a set of present-day species whose past includes reticulate events such as hybridisation and lateral gene transfer.…

种群与进化 · 定量生物学 2018-09-05 Joan Carles Pons , Charles Semple , Mike Steel

Neural Networks and Decision Trees: two popular techniques for supervised learning that are seemingly disconnected in their formulation and optimization method, have recently been combined in a single construct. The connection pivots on…

机器学习 · 统计学 2020-02-27 Giuseppe Nuti , Lluís Antoni Jiménez Rugama , Kaspar Thommen

Source code can be parsed into the abstract syntax tree (AST) based on defined syntax rules. However, in pre-training, little work has considered the incorporation of tree structure into the learning process. In this paper, we present…

机器学习 · 计算机科学 2021-07-16 Xue Jiang , Zhuoran Zheng , Chen Lyu , Liang Li , Lei Lyu

Dendrograms are a way to represent evolutionary relationships between organisms. Nowadays, these are inferred based on the comparison of genes or protein sequences by taking into account their differences and similarities. The genetic…

We introduce a simple algorithm for reconstructing phylogenies from multiple gene trees in the presence of incomplete lineage sorting, that is, when the topology of the gene trees may differ from that of the species tree. We show that our…

种群与进化 · 定量生物学 2011-09-30 Elchanan Mossel , Sebastien Roch

Phylogenetic networks model reticulate evolutionary histories. The last two decades have seen an increased interest in establishing mathematical results and developing computational methods for inferring and analyzing these networks. A…

种群与进化 · 定量生物学 2016-06-24 Jiafan Zhu , Yun Yu , Luay Nakhleh

An evolutionary tree (phylogenetic tree) is a binary, rooted, unordered tree that models the evolutionary history of currently living species in which leaves are labeled by species. In this paper, we investigate the problem of finding the…

种群与进化 · 定量生物学 2013-04-02 Soheil Jahangiri Tazehkand , Seyed Naser Hashemi , Hadi Poormohammadi

Phylogenetic trees elucidate evolutionary relationships among species, but phylogenetic inference remains challenging due to the complexity of combining continuous (branch lengths) and discrete parameters (tree topology). Traditional Markov…

种群与进化 · 定量生物学 2024-12-30 ChenRui Duan , Zelin Zang , Siyuan Li , Yongjie Xu , Stan Z. Li

Multiple sequence alignment is a key process in today's biology, and finding a relevant alignment of several sequences is much more challenging than just optimizing some improbable evaluation functions. Our approach for addressing multiple…

定量方法 · 定量生物学 2008-12-18 Frédéric Guinand , Yoann Pigné

Phylogenomics commonly aims to construct evolutionary trees from genomic sequence information. One way to approach this problem is to first estimate event-labeled gene trees (i.e., rooted trees whose non-leaf vertices are labeled by…

组合数学 · 数学 2019-05-09 Marc Hellmuth , Katharina T. Huber , Vincent Moulton

This paper is concerned with the approximation of high-dimensional functions in a statistical learning setting, by empirical risk minimization over model classes of functions in tree-based tensor format. These are particular classes of…

机器学习 · 统计学 2019-01-15 Erwan Grelier , Anthony Nouy , Mathilde Chevreuil

Phylogenetic inference can potentially result in a more accurate tree using data from multiple loci. However, if the loci are incongruent--due to events such as incomplete lineage sorting or horizontal gene transfer--it can be misleading to…

种群与进化 · 定量生物学 2016-03-10 Kevin Gori , Tomasz Suchan , Nadir Alvarez , Nick Goldman , Christophe Dessimoz

Phylogenetic trees are simple models of evolutionary processes. They describe conditionally independent divergent evolution of taxa from common ancestors. Phylogenetic trees commonly do not have enough flexibility to adequately model all…

种群与进化 · 定量生物学 2025-11-11 Jonathan D. Mitchell , Barbara R. Holland

Pairwise ordered tree alignment are combinatorial objects that appear in RNA secondary structure comparison. However, the usual representation of tree alignments as supertrees is ambiguous, i.e. two distinct supertrees may induce identical…

定量方法 · 定量生物学 2016-03-08 Cedric Chauve , Julien Courtiel , Yann Ponty

We address the problem of building and maintaining distributed spanning trees in highly dynamic networks, in which topological events can occur at any time and any rate, and no stable periods can be assumed. In these harsh environments, we…

分布式、并行与集群计算 · 计算机科学 2013-07-23 Arnaud Casteigts , Serge Chaumette , Frédéric Guinand , Yoann Pigné

Recovering a tree that represents the evolutionary history of a group of species is a key task in phylogenetics. Performing this task using sequence data from multiple genetic markers poses two key challenges. The first is the discordance…

种群与进化 · 定量生物学 2026-03-12 Ortal Reshef , Ofer Glassman , Or Zuk , Yariv Aizenbud , Boaz Nadler , Ariel Jaffe

When estimating a phylogeny from a multiple sequence alignment, researchers often assume the absence of recombination. However, if recombination is present, then tree estimation and all downstream analyses will be impacted, because…

统计方法学 · 统计学 2014-10-08 Peter B. Chi , Sujay Chattopadhyay , Philippe Lemey , Evgeni V. Sokurenko , Vladimir N. Minin

The recent explosion of genomic data has underscored the need for interpretable and comprehensive analyses that can capture complex phylogenetic relationships within and across species. Recombination, reassortment and horizontal gene…

定量方法 · 定量生物学 2016-09-28 Pablo G. Camara , Arnold J. Levine , Raul Rabadan