相关论文: Action potential as a pressure pulse propagating i…

The propagation of an action potential is accompanied by mechanical and thermal effects. Several mathematical models explain the deformation of the unmyelinated axon wall. In this paper, the deformation of the myelinated axon wall is…

Hydrated interfaces are ubiquitous in biology and appear on all length scales from ions, individual molecules to membranes and cellular networks. In vivo, they comprise a high degree of self-organization and complex entanglement, which…

One of the most celebrated successes in computational biology is the Hodgkin-Huxley framework for modeling electrically active cells. This framework, expressed through a set of differential equations, synthesizes the impact of ionic…

Gap junctions are channels in cell membranes allowing ions to pass directly between cells. They connect cells throughout the body, including heart myocytes, neurons, and astrocytes. Propagation mediated by gap junctions can be passive or…

The activation of a $K^+$ channel sensor in two sequential stages during a voltage clamp may be described as the translocation of a Brownian particle in an energy landscape with two large barriers between states. A solution of the…

In studies of the brain and the nervous system, extracellular signals - as measured by local field potentials (LFPs) or electroencephalography (EEG) - are of capital importance, as they allow to simultaneously obtain data from multiple…

A study is made of how active membrane proteins can modify the long wavelength mechanics of fluid membranes. The activity of the proteins is modelled as disturbing the protein surroundings through non-local force distributions of which a…

We numerically investigate the influence of intrinsic channel noise on the dynamical response of delay-coupling in neuronal systems. The stochastic dynamics of the spiking is modeled within a stochastic modification of the standard…

We investigate neuronal excitability in the Hodgkin-Huxley model under temporal interference (TI) stimulation in a previously unexplored sub-Hz resonant regime and uncover a striking nonlinear response that we term 'multi-tongue frequency…

Investigations of nerve activity have focused predominantly on electrical phenomena. Nerves, however, are thermodynamic systems, and changes in temperature and in the dimensions of the nerve can also be observed during the action potential.…

Plants exhibit dynamic bioelectric properties that facilitate information transfer across tissues. This study investigates action potentials (APs) in Nicotiana tabacum recorded within a custom-designed growth chamber using a biosignal…

Coordinated motion of cell monolayers during epithelial wound healing and tissue morphogenesis involves mechanical stress generation. Here we propose a model for the dynamics of epithelial expansion that couples mechanical deformations in…

In this work, we propose to catch the complexity of the membrane potential's dynamic of a motoneuron between its spikes, taking into account the spikes from other neurons around. Our approach relies on two types of data: extracellular…

Biological signaling is imagined as a combination of activation and transport. The former is triggered by local molecular interactions and the latter is the result of molecular diffusion. However, other fundamental physical principles of…

We derive a charge conserving phase space cable equation for the propagating action potential, expressing ionic, capacitive and axoplasmic currents as functions of membrane potential. The new equation prediction of ionic current crossing…

We continue the work of a series of previous studies of a mathematical model that describes the mean-field limit behavior of a homogeneous network of excitatory point spiking neurons. Contrary to other models, here noise is intrinsic to the…

Single neuron models have a long tradition in computational neuroscience. Detailed biophysical models such as the Hodgkin-Huxley model as well as simplified neuron models such as the class of integrate-and-fire models relate the input…

Pulsatory activity patterns, driven by mechanochemical feedback, are prevalent in many biological systems. Here we present a theoretical framework to elucidate the mechanical origin and regulation of pulsatile activity patterns within…

Currently, biological signaling is envisaged as a combination of activation and movement, triggered by local molecular interactions and molecular diffusion, respectively. However, we here suggest, that other fundamental physical mechanisms…

The excitation of many cells and tissues is associated with cell mechanical changes. The evidence presented herein corroborates that single cells deform during an action potential (AP). It is demonstrated that excitation of plant cells…