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The mechanics of crawling cells on a substrate is investigated by using a minimal model that satisfies the force-free condition. A cell is described by two subcellular elements connected by a linear actuator that changes the length of the…

软凝聚态物质 · 物理学 2018-04-18 Mitsusuke Tarama , Ryoichi Yamamoto

The accumulation of swimming bacteria near surfaces may lead to biological processes such as biofilm formation and wound infection. Previous experimental observations of Vibrio alginolyticus showed an interesting correlation between the…

生物物理 · 物理学 2023-07-04 Vahid Nourian , Henry Shum

Molecular motor proteins serve as an essential component of intracellular transport by generating forces to haul cargoes along cytoskeletal filaments. Two species of motors that are directed oppositely (e.g. kinesin, dynein) can be attached…

亚细胞过程 · 定量生物学 2017-05-10 Christopher E. Miles , James P. Keener

Biological membranes and vesicles play a central role in living systems, forming dynamic interfaces that regulate cellular organization and function. Classical descriptions of membrane mechanics that are rooted in equilibrium statistical…

软凝聚态物质 · 物理学 2026-02-24 Sreekanth Ramesh , Prashant K. Purohit , Yashashree Kulkarni

The persistent dynamics of active particles makes them explore extended portions of an obstacle's boundary during collisions. From impact to escape, the net applied forces depend on the curvature of the wall and increase in the presence of…

Power-law dwell times have been observed for molecular motors in living cells, but the origins of these trapped states are not known. We introduce a minimal model of motors moving on a two-dimensional network of filaments, and simulations…

Swimming micro-organisms such as flagellated bacteria and sperm cells have fascinating locomotion capabilities. Inspired by their natural motion, there is an ongoing effort to develop artificial robotic nano-swimmers for potential in-body…

流体动力学 · 物理学 2023-05-31 Jithu Paul , Yizhar Or , Oleg Gendelman

We model analytically the dynamics of a cytoskeletal filament in a motility assay. The filament is described as rigid rod free to slide in two dimensions. The motor proteins consist of polymeric tails tethered to the plane and modeled as…

统计力学 · 物理学 2015-03-19 Shiladitya Banerjee , M. Cristina Marchetti , Kristian Müller-Nedebock

We show that the recent experimental observation of the rectification of swimming bacteria in a system with an array of asymmetric barriers occurs due to the ballistic component of the bacteria trajectories introduced by the bacterial…

软凝聚态物质 · 物理学 2009-11-13 M. B. Wan , C. J. Olson Reichhardt , Z. Nussinov , C. Reichhardt

The transport by molecular motors along cytoskeletal filaments is studied theoretically in the presence of static defects. The movements of single motors are described as biased random walks along the filament as well as binding to and…

生物物理 · 物理学 2009-05-08 Yan Chai , Reinhard Lipowsky , Stefan Klumpp

Adding a non-adsorbing polymer to passive colloids induces an attraction between the particles via the `depletion' mechanism. High enough polymer concentrations lead to phase separation. We combine experiments, theory and simulations to…

软凝聚态物质 · 物理学 2016-07-13 J. Schwarz-Linek , C. Valeriani , A. Cacciuto , M. E. Cates , D. Marenduzzo , A. N. Morozov , W. C. K. Poon

Single molecule experiments on bacteriophages show an exponential scaling for the dependence of mobility on the length of DNA within the capsid. It has been suggested that this could be due to the "capstan mechanism" -- the exponential…

生物物理 · 物理学 2017-05-31 Rahul Arun , Sandip Ghosal

Molecular motors transport various cargos along cytoskeletal filaments, analogous to trucks on roads. In contrast to vehicles, however, molecular motors do not work alone but in small teams. We describe a simple model for the transport of a…

统计力学 · 物理学 2008-07-08 Melanie J. I. Müller , Janina Beeg , Rumiana Dimova , Stefan Klumpp , Reinhard Lipowsky

Bacteriophage viruses, one of the most abundant entities in our planet, lack the ability to move independently. Instead, they crowd fluid environments in anticipation of a random encounter with a bacterium. Once they land on the cell body…

生物物理 · 物理学 2018-11-05 Panayiota Katsamba , Eric Lauga

Due to their morphology, the dynamics of bacteria suspended in media can exhibit complex behaviors. In the presence of a shear, swimming bacteria experience a drift perpendicular to the shear plane. This drift, termed rheotaxis, is studied…

We analyze the role of the force-dependent kinetics of motor proteins in the stability of antiparallel arrays of polar filaments, such as those in the mitotic spindle. We determine the possible stable structures and show that there exists…

亚细胞过程 · 定量生物学 2007-05-23 Otger Campas , Jaume Casademunt , Ignacio Pagonabarraga

We investigate the dynamics of a pair of rigid rotating helices in a viscous fluid, as a model for bacterial flagellar bundle and a prototype of microfluidic pumps. Combining experiments with hydrodynamic modeling, we examine how spacing…

流体动力学 · 物理学 2025-05-13 Chijing Zang , Luke Omodt , Moumita Dasgupta , Xiang Cheng

Bacterial cellulose is an important class of biomaterials which can be grown in well-controlled laboratory and industrial conditions. The cellulose structure is affected by several biological, chemical and environmental factors, including…

生物物理 · 物理学 2021-07-28 Sung-Ha Hong , Jia Yang , Mahdi Davoodianidalik , Horst Punzmann , Michael Shats , Hua Xia

In the presence of ATP, molecular motors generate active force dipoles that drive suspensions of protein filaments far from thermodynamic equilibrium, leading to exotic dynamics and pattern formation. Microscopic modelling can help to…

生物物理 · 物理学 2015-06-17 D. A. Head , W. J. Briels , G. Gompper

The field of active matter explores the behaviors of self propelled agents out of equilibrium, with active suspensions, such as swimming bacteria in solutions, serving as impactful models. These systems exhibit spatio-temporal patterns akin…

软凝聚态物质 · 物理学 2025-08-26 Pratikshya Jena , Shradha Mishra