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We analyze the collective behavior of hydrodynamically coupled molecular motors. We show that the local fluxes induced by motors displacement can induce the experimentally observed bidirectional motion of cargoes and vesicles. By means of a…

软凝聚态物质 · 物理学 2017-11-22 P. Malgaretti , I. Pagonabarraga , J. F. Joanny

Self-propelling bacteria are a dream of nano-technology. These unicellular organisms are not just capable of living and reproducing, but they can swim very efficiently, sense the environment and look for food, all packaged in a body…

Bacterial flagellar swarming enables dense microbial populations to migrate collectively across surfaces, often resulting in emergent, coordinated behaviors. However, probing the underlying energetics of swarming at the single cluster level…

Active filaments, such as microtubules with attached cargo-carrying motor proteins, are important dynamic structures for fluid transport in and around living cells. The mathematical models of active filaments appearing in the literature…

流体动力学 · 物理学 2025-08-19 Ilteber R. Ozdemir , Bethany Clarke , Yongyun Hwang , Eric E. Keaveny

Microorganisms such as algae and bacteria move in a viscous environment with extremely low Reynolds ($Re$), where the viscous drag dominates the inertial forces. They have adapted to this environment by developing specialized features such…

机器人学 · 计算机科学 2024-12-10 Nnamdi Chikere , Yasemin Ozkan-Aydin

Processive molecular motors which drive the traffic of organelles in cells move in a directed way along cytoskeletal filaments. On large time scales, they perform motor walks, i.e., peculiar random walks which arise from the repeated…

统计力学 · 物理学 2007-05-23 Stefan Klumpp , Theo M. Nieuwenhuizen , Reinhard Lipowsky

Biomolecular motors use free energy to drive a variety of cellular tasks, including the transport of cargo, such as vesicles and organelles. We find that the widely-used `constant-force' approximation for the effect of cargo on motor…

统计力学 · 物理学 2023-04-11 Aidan I Brown , David A Sivak

We use a three-bead-spring model to investigate the dynamics of bi-flagellate micro-swimmers near a surface. While the primary dynamics and scattering are governed by geometric-dependent direct contact, the fluid flows generated by the…

生物物理 · 物理学 2017-08-17 Enkeleida Lushi , Vasily Kantsler , Raymond E. Goldstein

Motile bacteria are known to accumulate at surfaces, eventually leading to changes in bacterial motility and bio-film formation. We use a novel two-colour, three-dimensional Lagrangian tracking technique, to follow simultaneously the body…

The movement of motor particles consisting of one or several molecular motors bound to a cargo particle is studied theoretically. The particles move on patterns of immobilized filaments. Several patterns are described for which the motor…

统计力学 · 物理学 2009-11-11 Stefan Klumpp , Reinhard Lipowsky

We demonstrate that internal pivot-like defects, arising from rigor mutant motor proteins that bind without stepping, fundamentally reshape the dynamics of semiflexible filaments in two-dimensional motility assays. Using large-scale…

生物物理 · 物理学 2025-09-29 Sandip Roy , Debasish Chaudhuri , Abhishek Chaudhuri

In nature, many unicellular organisms are able to swim with the help of beating filaments, where local energy input leads to cooperative undulatory beating motion. Here, we investigate by employing reinforcement learning how undulatory…

生物物理 · 物理学 2025-11-04 Fumiya Tokoro , Hideki Takayama , Shinji Deguchi , Andreas Zöttl , Daiki Matsunaga

A simple model for simulating flows of active suspensions is investigated. The approach is based on dissipative particle dynamics. While the model is potentially applicable to a wide range of self-propelled particle systems, the specific…

流体动力学 · 物理学 2015-10-08 Denis F. Hinz , Alexander Panchenko , Tae-Yeon Kim , Eliot Fried

We present a theoretical investigation of thermal fluctuation statistics in a molecular motor. Energy transfer in the motor is described using a multidimensional discrete master equation with nearest-neighbor hopping. In this theory, energy…

统计力学 · 物理学 2014-01-07 K. J. Challis , M. W. Jack

The purpose of this work is to present the concept of an autonomous Stirling-like engine powered by anisotropy of thermodynamic fluctuations. Specifically, simultaneous contact of a thermodynamic system with two heat baths along coupled…

Active contributions to fluctuations are a direct consequence of metabolic energy consumption in living cells. Such metabolic processes continuously create active forces, which deform the membrane to control motility, proliferation as well…

生物物理 · 物理学 2018-10-02 Hervé Turlier , Timo Betz

Living cells exhibit an important out-of-equilibrium mechanical activity, mainly due to the forces generated by molecular motors. These motor proteins, acting individually or collectively on the cytoskeleton, contribute to the violation of…

生物物理 · 物理学 2009-01-21 Francois Gallet , Delphine Arcizet , Pierre Bohec , Alain Richert

The course of a peritrichous bacterium such as E. coli crucially depends on the level of synchronization and self-organization of several rotating flagella. However, the rotation of each flagellum generates counter body movements which in…

生物物理 · 物理学 2015-11-11 Tapan Chandra Adhyapak , Holger Stark

The self-organization of microbial ecosystems involves a large variety of mechanisms, ranging from biochemical signaling to population dynamics. Among these, the role of motility regulation has been little studied, despite the importance of…

统计力学 · 物理学 2025-03-18 Alberto Dinelli , Ada Altieri , Julien Tailleur

A wide range of microorganisms, e.g. bacteria, propel themselves by rotation of soft helical tails, also known as flagella. Due to the small size of these organisms, viscous forces overwhelm inertial effects and the flow is at low Reynolds…

机器人学 · 计算机科学 2021-03-11 Yayun Du , Andrew Miller , Mohammad Khalid Jawed
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