相关论文: Cyclooxygenase inhibition in ischemic brain injury

Motivated by the pressing need for suicide prevention through improving behavioral healthcare, we use medical claims data to study the risk of subsequent suicide attempts for patients who were hospitalized due to suicide attempts and later…

Previous models of the cerebrovascular smooth muscle cell have not addressed the interaction between the electrical, chemical and mechanical components of cell function during the development of active tension. These models are primarily…

Declarative memory, the memory that can be "declared" in words or languages, is made up of two dissociated parts: episodic memory and semantic memory. This dissociation has its neuroanatomical basis episodic memory is mostly associated with…

Chronic wounds represent a major public health problem affecting 6.5 million people in the United States. Ischemia represents a serious complicating factor in wound healing. In this paper we analyze a recently developed mathematical model…

Neurodegenerative diseases and traumatic brain injuries (TBI) are among the main causes of cognitive dysfunction in humans. Both manifestations exhibit the extensive presence of focal axonal swellings (FAS). FAS compromises the information…

The oxidative stress response is characterized by various effects on a range of biologic molecules. When examined at the protein level, both expression levels and protein modifications are altered by oxidative stress. While these effects…

Despite recent advances in brain research, understanding the various signals for pain and pain intensities in the brain cortex is still a complex task due to temporal and spatial variations of brain hemodynamics. In this paper we have…

Cardiovascular disease (CVD) remains the leading global cause of mortality, yet current risk stratification methods often fail to detect early, subclinical changes. Previous studies have generally not integrated retinal microvasculature…

Arterial tissue delamination, manifested as the failure between arterial layers, is a critical process in the rupture of atherosclerotic plaque, leading to potential life-threatening clinical consequences. Numerous models have been used to…

Neuronal membrane potentials fluctuate stochastically due to conductance changes caused by random transitions between the open and close states of ion channels. Although it has previously been shown that channel noise can nontrivially…

Parkinsons disease (PD) is considered one of the most frequent neurological diseases in the world. There is a need to study the early and efficient biomarkers of Parkinsons, such as changes in structural disorders like DNA and chromatin,…

A salient feature of prefrontal cortex organization is the vast diversity of cell types that support the temporal integration of events required for sculpting future responses. A major obstacle in understanding the routing of information…

The virus SARS-COV-2 caused disease COVID-19 has been declared a pandemic by WHO. Currently, over 210 countries and territories have been affected. Careful, well-designed drugs and vaccine for the total elimination of this virus seem to be…

In these companion papers, we study how the interrelated dynamics of sodium and potassium affect the excitability of neurons, the occurrence of seizures, and the stability of persistent states of activity. In this first paper, we construct…

Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo phenotypic changes and senescence, restricting cartilage…

Conventional deep brain stimulation (DBS) of basal ganglia uses high-frequency regular electrical pulses to treat Parkinsonian motor symptoms and has a series of limitations. Relatively new and not yet clinically tested optogenetic…

Quantification of information content and its temporal variation in intracellular calcium spike trains in neurons helps one understand functions such as memory, learning, and cognition. Such quantification could also reveal pathological…

In this paper, we study a modification of the mathematical model describing inflammation and demyelination patterns in the brain caused by Multiple Sclerosis proposed in [Lombardo et al. (2017), Journal of Mathematical Biology, 75,…

While ischemic stroke is a leading cause of death worldwide, there has been little success translating putative cerebroprotectants from rodent preclinical trials to human patients. We investigated computational image-based assessment tools…

Cerebral autoregulation (CA) is a fundamental mechanism that modulates cerebrovascular resistance, primarily by regulating the diameter of small cerebral vessels to maintain stable cerebral blood flow (CBF) in response to fluctuations in…