相关论文: Cyclooxygenase inhibition in ischemic brain injury
Cerebrovascular accident, or commonly known as stroke, is an acute disease with extreme impact on patients and healthcare systems and is the second largest cause of death worldwide. Fast and precise stroke lesion detection and location is…
Cortical visual impairment is amongst the key pathological causes of pediatric visual abnormalities predominantly resulting from hypoxic-ischemic brain injury. Such an injury results in profound visual impairments which severely impairs the…
Although substance use, such as alcohol intake, is known to be associated with cognitive decline during aging, its direct influence on the central nervous system remains incompletely understood. In this study, we investigate the influence…
For long it has been known that specific patterns of folding are necessary for an optimally functioning brain. For instance, lissencephaly and polymicrogyria can lead to severe mental retardation, short life expectancy, epileptic seizures,…
Dynamical effects on healthy brains and brains affected by tumor are investigated via numerical simulations. The brains are modeled as multilayer networks consisting of neuronal oscillators, whose connectivities are extracted from Magnetic…
The theoretical basis of neuronal coding, associated with short term degradation in synaptic transmission, is a matter of debate in the literature. In fact, electrophysiological signals are commonly characterized as inversely proportional…
The field of brain-computer interfaces is poised to advance from the traditional goal of controlling prosthetic devices using brain signals to combining neural decoding and encoding within a single neuroprosthetic device. Such a device acts…
The main reasons for the ongoing COVID-19 (coronavirus disease 2019) pandemic are the unavailability of recommended efficacious drugs or vaccines along with the human to human transmission nature of SARS-CoV-2 virus. So, there is urgent…
A simulation model for the spread and control of lesions in the brain is constructed using a planar network (graph) representation for the Central Nervous System (CNS). The model is inspired by the lesion structures observed in the case of…
We expose first a biological model of memory based on one hand of the mechanical oscillations of axons during action potential and on the other hand on the changes in the extra cellular matrix composition when a mechanical strain is applied…
Structural magnetic resonance imaging (MRI) can be used to detect lesions in the brains of multiple sclerosis (MS) patients. The formation of these lesions is a complex process involving inflammation, tissue damage, and tissue repair, all…
Introduction: The global COVID-19 pandemic has heightened stress, anxiety, and sadness, leading to increased rates of insomnia (6-10%). This study explores the effectiveness of supportive psychotherapy, specifically Cognitive-Behavioral…
Recent experimental evidences indicate that pyruvate, the final metabolite of glycolysis, has a remarkable protective effect against different types of brain injury. The purpose of this study was to assess the neuroprotective effect and the…
Mild cognitive impairment (MCI) leading to dementia results in a constellation of psychiatric disorders including depression, mood disorders, schizophrenia and others. With increasing age, mild cognitive impairment leads to increased…
The initial reaction of the body to pathogenic microbial infection or severe tissue trauma is an acute inflammatory response. The magnitude of such a response is of critical importance, since an uncontrolled response can cause further…
Gene expression represents a fundamental interface between genes and environment in the development and ongoing plasticity of the human organism. Individual differences in gene expression are likely to underpin much of human diversity,…
Accurate estimation of brain infarction (i.e., irreversibly damaged tissue) is critical for guiding treatment decisions in acute ischemic stroke. Reliable infarct prediction informs key clinical interventions, including the need for patient…
Epileptogenic lesions have higher concentrations of sodium than does normal brain tissue. Such lesions are palpably recognized by a surgeon and then excised in order to eliminate epileptic seizures with their associated abnormal electrical…
Bayesian Cox semiparametric regression is an important problem in many clinical settings. Bayesian procedures provide finite-sample inference and naturally incorporate prior information if MCMC algorithms and posteriors are well behaved.…
Stroke is a leading cause of disability and death worldwide, with ischemic strokes accounting for nearly 80% of cases. Fewer than 5% of patients receive the sole validated pharmacotherapy, intravenous thrombolysis, highlighting the urgent…