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DNA-functionalized particles have great potential for the design of complex self-assembled materials. The major hurdle in realizing crystal structures from DNA-functionalized particles is expected to be kinetic barriers that trap the system…

软凝聚态物质 · 物理学 2015-03-06 Yajun Ding , Jeetain Mittal

The problem of DNA-DNA interaction mediated by divalent counterions is studied using computer simulation. Although divalent counterions cannot condense free DNA molecules in solution, we show that if DNA configurational entropy is…

生物大分子 · 定量生物学 2011-03-29 SeIl Lee , Tung T Le , Toan T Nguyen

Common wisdom dictates that physical systems become less ordered when heated to higher temperature. However, several systems display the opposite phenomenon and move to a more ordered state upon heating, e.g. at low temperature…

无序系统与神经网络 · 物理学 2024-08-13 Flaviano Morone , Dries Sels

RNA folding is a kinetic process governed by the competition of a large number of structures stabilized by the transient formation of base pairs that may induce complex folding pathways and the formation of misfolded structures. Despite of…

生物物理 · 物理学 2009-03-16 M. Manosas , I. Junier , F. Ritort

Recently it has been shown that a strongly interacting colloidal mixture consisting of oppositely driven particles, undergoes a nonequilibrium transition towards lane formation provided the driving strength exceeds a threshold value. We…

软凝聚态物质 · 物理学 2009-11-10 J. Chakrabarti , J. Dzubiella , H. Lowen

Single molecule studies, at constant force, of the separation of double-stranded DNA into two separated single strands may provide information relevant to the dynamics of DNA replication. At constant applied force, theory predicts that the…

We discuss the thermodynamic behaviour near the force induced unzipping transition of a double stranded DNA in two different ensembles. The Y-fork is identified as the coexisting phases in the fixed distance ensemble. From finite size…

软凝聚态物质 · 物理学 2007-05-23 Rajeev Kapri , Somendra M. Bhattacharjee

Cells deploy robust mechanisms to repair DNA damage, safeguarding genomic stability and cellular health, but the physical principles underlying these processes remain incompletely understood. Experiments show \emph{in vitro} that upon a DNA…

生物物理 · 物理学 2026-05-26 Rakesh Das , Tarun Mascarenhas , Nagaraja Chappidi , Simon Alberti , Frank Jülicher

Optical internal transitions relevant to ODR experiments are computed for the biexciton in a quantum dot in the strong confinement regime. Valence sub-band mixing effects are taken into account in second order pertubation theory. The…

介观与纳米尺度物理 · 物理学 2007-05-23 Ricardo Perez , Augusto Gonzalez

We develop a simple model to study the effects of an applied force on the melting of a double stranded DNA (dsDNA). Using this model, we could study the stretching, unzipping, rupture and slippage like transition in a dsDNA. We show that in…

软凝聚态物质 · 物理学 2015-05-14 Amit Raj Singh , D. Giri , S. Kumar

Loops are essential secondary structure elements in folded DNA and RNA molecules and proliferate close to the melting transition. Using a theory for nucleic acid secondary structures that accounts for the logarithmic entropy c ln m for a…

统计力学 · 物理学 2011-05-02 Thomas R. Einert , Henri Orland , Roland R. Netz

Glass forming liquids exhibit a rich phenomenology upon confinement. This is often related to the effects arising from wall-fluid interactions. Here we focus on the interesting limit where the separation of the confining walls becomes of…

软凝聚态物质 · 物理学 2014-07-25 S. Mandal , S. Lang , M. Gross , M. Oettel , D. Raabe , T. Franosch , F. Varnik

We propose a new strategy to improve the self-assembly properties of DNA-functionalised colloids. The problem that we address is that DNA-functionalised colloids typically crystallize in a narrow temperature window, if at all. The…

软凝聚态物质 · 物理学 2013-01-22 B. M. Mognetti , M. E. Leunissen , D. Frenkel

Literature data on the properties of DNA open states are reviewed and analyzed. These states are formed as a result of strong DNA fluctuations and have a great impact on a number of biochemical processes; among them is charge transfer in…

生物大分子 · 定量生物学 2020-02-04 A. S. Shigaev , O. A. Ponomarev , V. D. Lakhno

We investigate irreversibility and dissipation in single molecules that cooperatively fold/unfold in a two state manner under the action of mechanical force. We apply path thermodynamics to derive analytical expressions for the average…

统计力学 · 物理学 2009-02-25 Maria Manosas , Alessandro Mossa , Nuria Forns , Josep Maria Huguet , Felix Ritort

The onset of an "eye-phase" and its role during the DNA unzipping is studied when a force is applied to the interior of the chain. The directionality of the hydrogen bond introduced here shows oscillations in force-extension curve similar…

软凝聚态物质 · 物理学 2015-05-13 Debaprasad Giri , Sanjay Kumar

Reentrance, the return of a system from an ordered phase to a previously encountered less-ordered one as a controlled parameter is continuously varied, is a recurring theme found in disparate physical systems, from condensed matter to black…

DNA strand displacement is a key reaction in DNA homologous recombination and DNA mismatch repair and is also heavily utilized in DNA-based computation and locomotion. Despite its ubiquity in science and engineering, sequence-dependent…

生物物理 · 物理学 2016-04-13 Bo Broadwater , Harold Kim

We consider force-induced unzipping transition for a heterogeneous DNA model with a long-range correlated base-sequence. It is shown that as compared to the uncorrelated situation, long-range correlations smear the unzipping…

统计力学 · 物理学 2007-05-23 A. E. Allahverdyan , Zh. S. Gevorkian

We consider force-induced unzipping transition for a heterogeneous DNA model with a correlated base-sequence. Both finite-range and long-range correlated situations are considered. It is shown that finite-range correlations increase…

软凝聚态物质 · 物理学 2009-11-10 A. E. Allahverdyan , Zh. S. Gevorkian , Chin-Kun Hu , Ming-Chya Wu