相关论文: MAPK Cascades as Feedback Amplifiers
We present a theoretical formalism to study steady state information transmission in type 1 coherent feed-forward loop motif with an additive signal integration mechanism. Our construct allows a two-step cascade to be slowly transformed…
Signal transduction in biological cells is effected by signaling pathways that typically include multiple feedback loops. Here we analyze information transfer through a prototypical signaling module with biochemical feedback. The module…
Cells must continuously sense and respond to time-varying environmental stimuli. These signals are transmitted and processed by biochemical signalling networks. However, the biochemical reactions making up these networks are intrinsically…
Multi-antenna precoding effectively mitigates the interference in wireless networks. However, the precoding efficiency can be significantly degraded by the overhead due to the required feedback of channel state information (CSI). This paper…
We introduce a one-way, one-quantum cascade, whereby a single excitation proceeds one-directionwise in a ladder of energy levels. This makes a variation from more famous two-way cascades where the excitation can go up and down following its…
Proteins with multiple binding sites play important roles in cell signaling systems by nucleating protein complexes in which, for example, enzymes and substrates are co-localized. Proteins that specialize in this function are called by a…
Sudden and abrupt changes can occur in a nonlinear system within many fields of science when such a system crosses a tipping point and rapid changes of the system occur in response to slow changes in an external forcing. These can occur…
Peaks associated to multiple Andreev reflections have been used to identify the number of conduction channels, and their transmitivity in mesoscopic superconducting junctions. We analyze the influence of the detailed shape of each channel,…
Recent biological research has sought to understand how biochemical signaling pathways, such as the mitogen-activated protein kinase (MAPK) family, influence the migration of a population of cells during wound healing. Fisher's Equation has…
In the realm of reconfigurable intelligent surface (RIS)-assisted communication systems, the connection between a base station (BS) and user equipment (UE) is formed by a cascaded channel, merging the BS-RIS and RIS-UE channels. Due to the…
The effectiveness of biochemical antivirals are vulnerable to mutations, motivating physical approaches. Recent experiments with ultrasound reveal viral disruption at MHz frequencies, yet the mechanism remains unclear. We model viruses as…
In recent years, machine learning models have been increasingly applied to spectroscopic datasets for chemical and biomedical analysis. For their successful adoption, particularly in clinical and safety-critical settings, professionals and…
Integrated microwave photonic (MWP) front-ends are capable of ultra-broadband signal reception and processing. However, state-of-the-art demonstrations are limited to performing only one specific functionality at any given time, which fails…
In order to transmit biochemical signals, biological regulatory systems dissipate energy with concomitant entropy production. Additionally, signaling often takes place in challenging environmental conditions. In a simple model regulatory…
Scaffolding proteins that direct the assembly of multiple kinases into a spatially localized signaling complex are often essential for the maintenance of an appropriate biological response. Although scaffolds are widely believed to have…
We investigate if feedback can increase the capacity of an energy harvesting communication channel where a transmitter powered by an exogenous energy arrival process and equipped with a finite battery communicates to a receiver over a…
Macrophages function as sentinel, cell-regulatory hubs capable of initiating, perpetuating and contributing to the resolution of an inflammatory response, following their activation from a resting state. Highly complex and varied gene…
Signaling in enzymatic networks is typically triggered by environmental fluctuations, resulting in a series of stochastic chemical reactions, leading to corruption of the signal by noise. For example, information flow is initiated by…
The realization of negative refraction in atomic gases requires a strong magnetic response of the atoms. Current proposals for such systems achieve an enhancement of the magnetic response by a suitable laser field configuration, but still…
Current scientific consensus holds that sound is transmitted, solely mechanically, from the tympanum to the cochlea via ossicles. But this theory does not explain the hearing extreme quality regarding high frequencies in mammals. So, we…