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We introduce a new class of methods for finite-sample false discovery rate (FDR) control in multiple testing problems with dependent test statistics where the dependence is fully or partially known. Our approach separately calibrates a…

统计方法学 · 统计学 2020-07-22 William Fithian , Lihua Lei

Correlated observations are ubiquitous phenomena in a plethora of scientific avenues. Tackling this dependence among test statistics has been one of the pertinent problems in simultaneous inference. However, very little literature exists…

统计理论 · 数学 2024-11-20 Monitirtha Dey

In many practical applications of multiple hypothesis testing using the False Discovery Rate (FDR), the given hypotheses can be naturally partitioned into groups, and one may not only want to control the number of false discoveries (wrongly…

统计方法学 · 统计学 2016-11-01 Rina Foygel Barber , Aaditya Ramdas

Inequalities are key tools to prove FDR control of a multiple test. The present paper studies upper and lower bounds for the FDR under various dependence structures of p-values, namely independence, reverse martingale dependence and…

统计理论 · 数学 2015-02-18 Philipp Heesen , Arnold Janssen

Given a multiple testing situation, the null hypotheses that appear to have sufficiently low probabilities of truth may be rejected using a simple, nonparametric method of decision theory. This applies not only to posterior levels of…

概率论 · 数学 2025-10-20 David R. Bickel

In this article, we propose a generalized weighted version of the well-known Benjamini-Hochberg (BH) procedure. The rigorous weighting scheme used by our method enables it to encode structural information from simultaneous multi-way…

统计方法学 · 统计学 2021-05-25 Shinjini Nandi , Sanat K. Sarkar

The mitigation of false positives is an important issue when conducting multiple hypothesis testing. The most popular paradigm for false positives mitigation in high-dimensional applications is via the control of the false discovery rate…

统计方法学 · 统计学 2018-07-17 Hien D. Nguyen , Yohan Yee , Geoffrey J. McLachlan , Jason P. Lerch

The local false discovery rate (lfdr) of Efron et al. (2001) enjoys major conceptual and decision-theoretic advantages over the false discovery rate (FDR) as an error criterion in multiple testing, but is only well-defined in Bayesian…

统计理论 · 数学 2025-02-25 Daniel Xiang , Jake A. Soloff , William Fithian

We propose a novel multiple testing methodology for controlling the false discovery rate (FDR) in high-dimensional linear models that integrates model-X knockoff techniques with debiased penalized regression estimators. At the foundation of…

统计方法学 · 统计学 2026-03-17 Jinyuan Chang , Chenlong Li , Cheng Yong Tang , Zhengtian Zhu

We provide the first differentially private algorithms for controlling the false discovery rate (FDR) in multiple hypothesis testing, with essentially no loss in power under certain conditions. Our general approach is to adapt a well-known…

统计理论 · 数学 2015-11-13 Cynthia Dwork , Weijie Su , Li Zhang

Multiple hypothesis testing is a significant problem in nearly all neuroimaging studies. In order to correct for this phenomena, we require a reliable estimate of the Family-Wise Error Rate (FWER). The well known Bonferroni correction…

统计计算 · 统计学 2015-02-17 Chris Hinrichs , Vamsi K Ithapu , Qinyuan Sun , Sterling C Johnson , Vikas Singh

Often in multiple testing, the hypotheses appear in non-overlapping blocks with the associated $p$-values exhibiting dependence within but not between blocks. We consider adapting the Benjamini-Hochberg method for controlling the false…

统计方法学 · 统计学 2016-11-11 Wenge Guo , Sanat Sarkar

Large-scale multiple testing with correlated and heavy-tailed data arises in a wide range of research areas from genomics, medical imaging to finance. Conventional methods for estimating the false discovery proportion (FDP) often ignore the…

统计方法学 · 统计学 2018-09-19 Jianqing Fan , Yuan Ke , Qiang Sun , Wen-Xin Zhou

Much effort has been made to improve the famous step up test of Benjamini and Hochberg given by linear critical values $\frac{i\alpha}{n}$. It is pointed out by Gavrilov, Benjamini and Sarkar that step down multiple tests based on the…

统计理论 · 数学 2016-08-10 Julia Benditkis , Arnold Janssen

Controlling the false discovery rate (FDR) in high-dimensional variable selection requires balancing rigorous error control with statistical power. Existing methods with provable guarantees are often overly conservative, creating a…

统计方法学 · 统计学 2026-02-06 Arnau Vilella , Jasin Machkour , Michael Muma , Daniel P. Palomar

Some effort has been undertaken over the last decade to provide conditions for the control of the false discovery rate by the linear step-up procedure (LSU) for testing $n$ hypotheses when test statistics are dependent. In this paper we…

统计理论 · 数学 2007-10-18 Helmut Finner , Thorsten Dickhaus , Markus Roters

In the online multiple testing problem, p-values corresponding to different null hypotheses are observed one by one, and the decision of whether or not to reject the current hypothesis must be made immediately, after which the next p-value…

统计方法学 · 统计学 2017-10-03 Aaditya Ramdas , Fanny Yang , Martin J. Wainwright , Michael I. Jordan

In the high dimensional regression analysis when the number of predictors is much larger than the sample size, an important question is to select the important variable which are relevant to the response variable of interest. Variable…

统计方法学 · 统计学 2023-01-09 Pengsheng Ji , Zhigen Zhao

We propose sufficient conditions and computationally efficient procedures for false discovery rate control in multiple testing when the $p$-values are related by a known \emph{dependency graph} -- meaning that we assume independence of…

统计方法学 · 统计学 2025-07-01 Drew T. Nguyen , William Fithian

In applications such as clinical safety analysis, the data of the experiments usually consists of frequency counts. In the analysis of such data, researchers often face the problem of multiple testing based on discrete test statistics,…

统计方法学 · 统计学 2019-08-15 Yalin Zhu , Wenge Guo