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Metastasis represents one of the main clinical challenge in cancer treatment since it is associated with the majority of deaths. Recent technological advances allow quantification of the dynamics of the process by means of noninvasive…

组织与器官 · 定量生物学 2015-11-06 Sébastien Benzekry , J. M. L. Ebos

The Landau-Brazovskii model provides a theoretical framework for describing various phases arising from competing short- and long-range interactions in many physical systems. In this work, we investigate phase transitions among various…

材料科学 · 物理学 2026-02-24 Zhiyi Zhang , Gang Cui , Kai Jiang , An-Chang Shi , Pingwen Zhang , Jianyuan Yin , Lei Zhang

Machine learning is often used in competitive scenarios: Participants learn and fit static models, and those models compete in a shared platform. The common assumption is that in order to win a competition one has to have the best…

机器学习 · 计算机科学 2018-03-14 Amin Khajehnejad , Shima Hajimirza

We study the simplest optomechanical system with a focus on the bistable regime. The covariance matrix formalism allows us to study both cooling and entanglement in a unified framework. We identify two key factors governing entanglement,…

量子物理 · 物理学 2015-05-27 R. Ghobadi , A. R. Bahrampour , C. Simon

We prove that random-cluster models with q larger than 1 on a variety of planar lattices have a sharp phase transition, that is that there exists some parameter p_c below which the model exhibits exponential decay and above which there…

概率论 · 数学 2021-12-17 Hugo Duminil-Copin , Ioan Manolescu

Cellular Potts models are broadly applied across developmental biology and cancer research. We overcome limitations of the traditional approach, which reinterprets a modified Metropolis sampling as ad hoc dynamics, by introducing a physical…

We proposed an evolving network model constituted by the same nodes but different edges. The competition between nodes and different links were introduced. Scale free properties have been found in this model by continuum theory. Different…

统计力学 · 物理学 2013-05-29 Jie Sun , Yizhi Ge , Sheng Li

We discuss the structure of the equation of motion that governs nucleation processes at first order phase transitions. From the underlying microscopic dynamics of a nucleating system, we derive by means of a non-equilibrium projection…

统计力学 · 物理学 2019-12-04 Anja Kuhnhold , Hugues Meyer , Graziano Amati , Philipp Pelagejcev , Tanja Schilling

The phase-space of a simple synchronization model is thoroughly investigated. The model considers two-mode stochastic oscillators, coupled through a pulse-like interaction controlled by simple optimization rules. A complex phase space is…

适应与自组织系统 · 物理学 2020-12-03 Szabolcs Horvát , Zoltán Néda

Cancer is viewed as a multistep process whereby a normal cell is transformed into a cancer cell through the acquisition of mutations. We reduce the complexities of cancer progression to a simple set of underlying rules that govern the…

细胞行为 · 定量生物学 2007-05-23 Sabrina L. Spencer , Matthew J. Berryman , Jose A. Garcia , Derek Abbott

Phase separation of biomolecular condensates promotes membrane-free compartmentalization in cells. The dynamics of these biocondensates is routinely regulated by energy-consuming processes. Here, we devise a theory pinpointing how active…

生物物理 · 物理学 2026-01-08 Benjamin Sorkin , Ned S. Wingreen

We exhibit a stochastic discrete time model that has exactly the Eigen model as its deterministic continuous limit. Such model can be divided into two phases: reproduction followed by neutral selection. This result suggests that Eigen model…

种群与进化 · 定量生物学 2011-02-03 Fabio Musso

We consider evolving networks in which each node can have various associated properties (a state) in addition to those that arise from network structure. For example, each node can have a spatial location and a velocity, or some more…

定量方法 · 定量生物学 2017-07-12 Jake P. Taylor-King , David Basanta , S. Jonathan Chapman , Mason A. Porter

Generalizing the cyclically competing three-species model (often referred to as the rock-paper-scissors game), we consider a simple system of population dynamics without spatial structures that involves four species. Unlike the previous…

种群与进化 · 定量生物学 2011-01-06 Sara O. Case , Clinton H. Durney , Michel Pleimling , R. K. P. Zia

We show how coupling techniques can be used in some metastable systems to prove that mean metastable exit times are almost constant as functions of the starting microscopic configuration within a "meta-stable set." In the example of the…

概率论 · 数学 2012-09-27 Alessandra Bianchi , Anton Bovier , Dmitry Ioffe

Networks of coupled nonlinear oscillators can display a wide range of emergent behaviours under variation of the strength of the coupling. Network equations for pairs of coupled oscillators where the dynamics of each node is described by…

动力系统 · 数学 2023-10-05 Rachel Nicks , Robert Allen , Stephen Coombes

We introduce the class of multistage stochastic optimization problems with a random number of stages. For such problems, we show how to write dynamic programming equations and detail the Stochastic Dual Dynamic Programming algorithm to…

最优化与控制 · 数学 2019-07-18 Vincent Guigues

We consider a general class of stochastic networks and ask which network nodes need to be controlled, and how, to stabilize and switch between desired metastable (target) states in terms of the first and second statistical moments of the…

适应与自组织系统 · 物理学 2016-07-20 Dmytro Bielievtsov , Josef Ladenbauer , Klaus Obermayer

A stochastic model, describing the growth of two competing infections on $\mathbb{R}^d$, is introduced. The growth is driven by outbursts in the infected region, an outburst in the type 1 (2) infected region transmitting the type 1 (2)…

概率论 · 数学 2015-09-24 Maria Deijfen , Olle Häggström , Jonathan Bagley

Phase diagrams are an invaluable tool for material synthesis and provide information on the phases of the material at any given thermodynamic condition. Conventional phase diagram generation involves experimentation to provide an initial…