定量生物学
Drug-releasing implants are gaining momentum in the treatment of glaucoma. However, they present several limitations, such as the inability to provide an even distribution of the drug in the trabecular meshwork. CFD simulations were used in…
Extracellular vesicles (EVs) are cell-derived secretions that mediate tissue homeostasis and intercellular communication through their diverse cargos, such as proteins. Distinct EV biogenesis pathways suggest specific association and…
Microproteins are a newly recognized and rapidly growing class of small proteins, typically encoded by fewer than 100 to 150 codons and translated from small open reading frames (smORFs). Although research has shown that smORFs and their…
In soccer penalty kicks, goalkeepers that orient their arms upward compared to downward can be misperceived as being taller - effectively recreating the Muller-Lyer illusion. The present study elaborates on previous research surrounding a…
There is now ample evidence that Motor Imagery (MI) contributes to improve motor performance. Previous studies provided evidence that its effectiveness remains dependent upon specific guidelines and recommendations. The body posture, as…
In the context of spiking neural networks, temporal coding of signals is increasingly preferred over the rate coding hypothesis due to its advantages in processing speed and energy efficiency. In temporal coding, synaptic delays are crucial…
The application of spectral-shifting films in greenhouses to shift green light to red light has shown variable growth responses across crop species. However, the yield enhancement of crops under altered light quality is related to the…
Spatial Transcriptomics enables mapping of gene expression within its native tissue context, but current platforms measure only a limited set of genes due to experimental constraints and excessive costs. To overcome this, computational…
Working memory requires the brain to maintain information from the recent past to guide ongoing behavior. Neurons can contribute to this capacity by slowly integrating their inputs over time, creating persistent activity that outlasts the…
Simulated microbial communities are used in benchmarking microbial abundance estimators and other bioinformatic utilities. To match current data scales, large simulated samples are needed, and many. The speed of current implementations…
Numerous studies have utilized NCBI data for genomic analysis, gene annotation, and identifying disease-associated variants, yet NCBI's epidemiological potential remains underexplored. This study demonstrates how NCBI datasets can be…
Early detection of cancer and cardiovascular diseases is fundamental to improving patient outcomes and reducing healthcare expenditure. Current cancer screening programs are targeted towards specific cancers and are often inaccessible to…
Modeling genomic sequences faces two unsolved challenges: the information density varies widely across different regions, while there is no clearly defined minimum vocabulary unit. Relying on either four primitive bases or independently…
Models such as AlphaFold2 and OpenFold have transformed protein structure prediction, yet their inner workings remain poorly understood. We present a methodology to systematically evaluate the contribution of individual OpenFold components…
DNA has emerged as a promising alternative for long-term data storage due to its high capacity, durability, and low-energy potential. However, storing data in DNA presents several challenges. First, it requires complex and costly…
Amyotrophic lateral sclerosis (ALS) is a degenerative disorder of the motor neurons that causes progressive paralysis in patients. Current treatment options aim to prolong survival and improve quality of life. However, due to the…
Density dependence occurs at the individual level and thus is greatly influenced by spatial local heterogeneity in habitat conditions. However, density dependence is often evaluated at the population level, leading to difficulties or even…
Antigenic escape constitutes the main mechanism allowing rapidly evolving viruses to achieve endemicity. Beyond granting immune escape, empirical evidence also suggests that mutations of viruses might increase their inter-host…
Trained on massive cross-species DNA corpora, DNA large language models (LLMs) learn the fundamental "grammar" and evolutionary patterns of genomic sequences. This makes them powerful priors for DNA sequence modeling, particularly over long…
AlphaFold 3 (AF3) is a powerful biomolecular structure-predicting tool based on the latest deep learning algorithms and revolutionized AI model architectures. A few of papers have already investigated its accuracy in predicting different…