定量方法
The visual cortex is a vital part of the brain, responsible for hierarchically identifying objects. Understanding the role of the lateral geniculate nucleus (LGN) as a prior region of the visual cortex is crucial when processing visual…
In the field of pharmacokinetics and pharmacodynamics (PKPD) modeling, which plays a pivotal role in the drug development process, traditional models frequently encounter difficulties in fully encapsulating the complexities of drug…
Physics-Informed Neural Networks (PINNs) are fast becoming an important tool to solve differential equations rapidly and accurately, and to identify the systems parameters that best agree with a given set of measurements. PINNs have been…
Scent marks play a crucial role in both territorial and sexual communication in many species. We investigated how free-ranging dogs respond to scent marks from individuals of different identities in terms of sex and group, across varying…
Proton pencil beam scanning (PBS) treatment planning for head and neck (H&N) cancers is a time-consuming and experience-demanding task where a large number of planning objectives are involved. Deep reinforcement learning (DRL) has recently…
Engineering biology requires precise control of biomolecular circuits, and Cybergenetics is the field dedicated to achieving this goal. A significant challenge in developing controllers for cellular functions is designing systems that can…
Recent advancements in deep learning, particularly large language models (LLMs), made a significant impact on how researchers study microbiome and metagenomics data. Microbial protein and genomic sequences, like natural languages, form a…
The SIR model is a classical model characterizing the spreading of infectious diseases. This model describes the time-dependent quantity changes among Susceptible, Infectious, and Recovered groups. By introducing space-depend effects such…
Metabolic pathways are fundamental maps in biochemistry that detail how molecules are transformed through various reactions. The complexity of metabolic network, where a single compound can play a part in multiple pathways, poses a…
Recent studies revealed structural and functional brain changes in heavy smokers. However, the specific changes in topological brain connections are not well understood. We used Gaussian Undirected Graphs with the graphical lasso algorithm…
Involved in mitotic condensation, interaction of transcriptional regulatory elements or isolation of structural domains, understanding loop formation is becoming a paradigm in the deciphering of chromatin architecture and its functional…
Myeloproliferative Neoplasms (MPN) are blood cancers that appear after acquiring a driver mutation in a hematopoietic stem cell. These hematological malignancies result in the overproduction of mature blood cells and, if not treated, induce…
Predicting molecular impact on cellular function is a core challenge in therapeutic design. Phenomic experiments, designed to capture cellular morphology, utilize microscopy based techniques and demonstrate a high throughput solution for…
Crown-like structures (CLS) in breast adipose tissue are formed as a result of macrophages clustering around necrotic adipocytes in specific patterns. As a histologic marker of local inflammation, CLS could have potential diagnostic utility…
Blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) is widely used to visualize brain activation regions by detecting hemodynamic responses associated with increased metabolic demand. While alternative MRI…
This study aimed to evaluate the effective management strategies of Albugo candida, a pathogen of white rust disease in red amaranth (Amaranthus tricolor L.), accountable for the reduction of seed production. The study was performed during…
Linear waste management systems are unsustainable and contribute to environmental degradation, economic inequity, and health disparities. Among the array of environmental challenges stemming from anthropogenic impacts, the management of…
Network inference, the task of reconstructing interactions in a complex system from experimental observables, is a central yet extremely challenging problem in systems biology. While much progress has been made in the last two decades,…
The VASARI MRI feature set is a quantitative system designed to standardise glioma imaging descriptions. Though effective, deriving VASARI is time-consuming and seldom used in clinical practice. This is a problem that machine learning could…
Epigenetics plays a key role in cellular differentiation and maintaining cell identity, enabling cells to regulate their genetic activity without altering the DNA sequence. Epigenetic regulation occurs within the context of hierarchically…