定量方法
The rich chemical information from tissue metabolomics provides a powerful means to elaborate tissue physiology or tumor characteristics at cellular and tumor microenvironment levels. However, the process of obtaining such information…
Designing novel functional proteins remains a slow and expensive process due to a variety of protein engineering challenges; in particular, the number of protein variants that can be experimentally tested in a given assay pales in…
Automated computational analysis of the vast chemical space is critical for numerous fields of research such as drug discovery and material science. Representation learning techniques have recently been employed with the primary objective…
Strokes are a leading cause of disability, with many experiencing difficulty in recovering arm movement, particularly hand function and grasping ability. There is currently no objective measure of movement quality, and without it,…
We present a sequential transfer learning framework for transformers on functional Magnetic Resonance Imaging (fMRI) data and demonstrate its significant benefits for decoding musical timbre. In the first of two phases, we pre-train our…
Objective: The purpose of this study is to reveal the mechanism of action of Yi Qi Tong Qiao Pill (YQTQP) in the treatment of allergic rhinitis (AR), as well as establish a paradigm for the researches on traditional Chinese medicine (TCM)…
The standard quantitative metric for evaluating enrichment capacity known as $\textit{LogAUC}$ depends on a cutoff parameter that controls what the minimum value of the log-scaled x-axis is. Unless this parameter is chosen carefully for a…
By September, 2022, more than 600 million cases of SARS-CoV-2 infection have been reported globally, resulting in over 6.5 million deaths. COVID-19 mortality risk estimators are often, however, developed with small unrepresentative samples…
Study reproducibility is essential to corroborate, build on, and learn from the results of scientific research but is notoriously challenging in bioinformatics, which often involves large data sets and complex analytic workflows involving…
We propose a speed-up method for the in-focus plane detection in digital holographic microscopy that can be applied to a broad class of autofocusing algorithms that involve repetitive propagation of an object wave to various axial locations…
Most phenomena related to biomedical tasks are inherently complex, and in many cases, are expressed as signals on biomedical Knowledge Graphs (KGs). In this work, we introduce the use of a new representation framework, the Prime Adjacency…
Lung cancer(LC) is a type of malignant neoplasm that originates in the bronchial mucosa or glands.As a clinically common nodule,solitary pulmonary nodules(SPNs) have a significantly higher probability of malignancy when they are larger than…
Objective: The study aimed to determine the prevalence of several non-communicable diseases (NCD) and analyze risk factors among adult patients seeking nutritional guidance in Dhaka, Bangladesh. Result: Our study observed the relationships…
Upper extremity motor impairment affects about 80\% of persons after strokes. For stroke rehabilitation, upper limb kinematic assessments have increasingly been used as primary or secondary outcome measures. Studying the upper extremity…
There is rising evidence of the health benefit associated with specific dietary interventions. Current food-disease databases focus on associations and treatment relationships but haven't provided a reasonable assessment of the strength of…
The unbounded permutations of biological molecules, including proteins and their constituent peptides, presents a dilemma in identifying the components of complex biosamples. Sequence search algorithms used to identify peptide spectra can…
Quantitative structure-property relationships (QSPRs) aid in understanding molecular properties as a function of molecular structure. When the correlation between structure and property weakens, a dataset is described as "rough," but this…
Flow cytometry is a powerful quantitative assay supporting high-throughput collection of single-cell data with a high dynamic range. For flow cytometry to yield reproducible data with a quantitative relationship to the underlying biology,…
Introduction: The Canadian Guidelines recommend physical activity for overall health benefits, including cognitive, emotional, functional, and physical health. However, traditional research methods are inefficient and outdated. This paper…
Today, intensity-modulated radiation therapy (IMRT) is one of the methods used to treat brain tumors. In conventional treatment planning methods, after identifying planning target volume (PTV), and organs at risk (OARs), and determining the…