种群与进化
In this work we address the analysis of discrete-time models of structured metapopulations subject to environmental stochasticity. Previous works on these models made use of the fact that migrations between the patches can be considered…
We consider a time-continuous Markov branching process of proliferating cells with a countable collection of types. Among-type transitions are inspired by the Tug-of-War process introduced in McFarland et al. as a mathematical model for…
We present a stochastic computational model of avascular tumors, emphasizing the detailed implementation of the first four so-called hallmarks of cancer: self-sufficiency in growth factors, resistance to growth inhibitors, avoidance of…
We introduce a novel, multi-scale model for affinity maturation, which aims to capture the intra-clonal, inter-clonal and epitope-specific organization of the B cell population in a germinal center. We describe the evolution of the B cell…
Geographic barriers prevent migration between populations, thereby facilitating speciation through allopatry. However, these barriers can exhibit dynamic behavior in nature, promoting cycles of expansion and contraction of populations. Such…
We consider a generalization of the classical logistic growth model introducing more than one inflection point. The growth, called multi-sigmoidal, is firstly analyzed from a deterministic point of view in order to obtain the main…
Fish harvesting often targets larger individuals, which can be sex-specific due to size dimorphism or differences in behaviors like migration and spawning. Sex-selective harvesting can have dire consequences in the long run, potentially…
Traditional disease transmission models assume that the infectious period is exponentially distributed with a recovery rate fixed in time and across individuals. This assumption provides analytical and computational advantages, however it…
Natural selection imply that any organisms including human being will evolve to improve its fitness advantage and the selected genotype or phenotype in equilibrium state will not vary over the time. However, evolutionary process of…
In December 2019, the first patients in Wuhan, China were diagnosed with a primary atypical pneumonia, which showed to be unknown and contagious. Since then, known as COVID-19 disease, the responsible viral pathogen, SARS-CoV-2, has spread…
Populations evolve by accumulating advantageous mutations. Every population has some spatial structure that can be modeled by an underlying network. The network then influences the probability that new advantageous mutations fixate.…
China is one of the countries with a high burden of tuberculosis, and although the number of new cases of tuberculosis has been decreasing year by year, the number of new infections per year has remained high and the diagnosis rate of…
During the last decades macroecology has identified broad-scale patterns of abundances and diversity of microbial communities and put forward some potential explanations for them. However, these advances are not paralleled by a full…
While quite a few recent papers have explored game-resource feedback using the framework of evolutionary game theory, almost all the studies are confined to using time-continuous dynamical equations. Moreover, in such literature, the effect…
Phylogenetics is now fundamental in life sciences, providing insights into the earliest branches of life and the origins and spread of epidemics. However, finding suitable phylogenies from the vast space of possible trees remains…
Proliferation of uninfected as well as infected hepatocytes and recycling of DNA-containing capsids are two major mechanisms playing significant roles in the clearance of hepatitis B virus (HBV) infection. In this study, the temporal…
While the importance of extreme conditions is recognised, patterns in species abundances are often interpreted through average environmental conditions within their distributional range. For marine species with pelagic larvae, temperature…
New technologies for acquiring biological information such as eDNA, acoustic or optical sensors, make it possible to generate spatial community observations at unprecedented scales. The potential of these novel community data to standardize…
Ecosystem models are often used to predict the consequences of management decisions in applied ecology, including fisheries management and threatened species conservation. These models are high-dimensional, parameter-rich, and nonlinear,…
Dengue is a vector-borne disease transmitted to humans by vectors of genus Aedes and is a global threat with health, social, and economic impact in many of the tropical countries including Sri Lanka. The virus transmission is significantly…