种群与进化
We have proposed an SEIR compartmental mathematical model. The prime objective of this study is to analyze and forecast the pandemic in Italy for the upcoming months. The basic reproduction number has been calculated. Based on the current…
Prokaryote mobilome genomes rely on host machineries for survival and replication. Given that mobile genetic elements (MGEs) derive their energy from host cells, we investigated the diversity of ATP-utilizing proteins in MGE genomes to…
West Nile virus (WNV) is a vector-borne pathogen of global relevance and is currently the most widely distributed flavivirus of encephalitis worldwide. This virus infects birds, humans, horses, and other mammals, and its transmission cycle…
We study model embeddability, which is a variation of the famous embedding problem in probability theory, when apart from the requirement that the Markov matrix is the matrix exponential of a rate matrix, we additionally ask that the rate…
Carlo Cipolla's stupidity quadrant and his five laws of stupidity were proposed for the first time in 1976. Exposed in a humorous mood by the author, these concepts nevertheless describe very serious features of the interactions among human…
Cultural traits such as words, names, decorative styles, and technical standards often assume arbitrary values and are thought to evolve neutrally. But neutral evolution cannot explain why some traits come and go in cycles of popularity…
In this paper we present a new modelling framework combining replicator dynamics (which is the standard model of frequency dependent selection) with the model of an age-structured population. The new framework allows for the modelling of…
Sea fishing is a highly mobile activity, favoured by the vastness of the oceans, the absence of physical boundaries and the abstraction of legislative boundaries. Understanding and anticipating this mobility is a major challenge for…
In this paper we explore a time-depended SEIR model, in which the dynamics of the infection in four groups from a selected target group (population), divided according to the infection, are modeled by a system of nonlinear ordinary…
A number of epidemics, including the SARS-CoV-1 epidemic of 2002-2004, have been known to exhibit superspreading, in which a small fraction of infected individuals is responsible for the majority of new infections. The existence of…
Viral transmission pathways have profound implications for public safety; it is thus imperative to establish a complete understanding of viable infectious avenues. Mounting evidence suggests SARS-CoV-2 can be transmitted via the air;…
Timely prediction of the COVID-19 progression is not possible without a comprehensive understanding of environmental factors that may affect the infection transmissibility. Studies addressing parameters that may influence COVID-19…
In this article, a biallelic reversible mutation model with linear and quadratic selection is analyzed. The approach reconnects to one proposed by Kimura ( Possibility of extensive neutral evolution under stabilizing selection with special…
At the end of 2020, policy responses to the SARS-CoV-2 outbreak have been shaken by the emergence of virus variants. The emergence of these more contagious, more severe, or even vaccine-resistant strains have challenged worldwide policy…
The spread of infectious epidemics is often accelerated by super-spreader events. Understanding their effect is important, particularly in the context of standard epidemiological models, which require estimates for parameters such as $R_0$.…
The estimate of the cumulative incidence of SARS-CoV-2 of 76% in Manaus by October 2020 by Buss et al. relies on the assumption of an exponentially-declining probability of sero-reversion over time. We present an alternative,…
Widespread growth signatures in COVID-19 confirmed case counts are reported, with sharp transitions between three distinct dynamical regimes (exponential, superlinear and sublinear). Through analytical and numerical analysis, a novel…
Chlamydia trachomatis (Ct) is the most reported sexually transmitted infection in the United States with a major cause of infertility and pelvic inflammatory disease among women. Despite decades of screening women for Ct, rates increase…
Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection worldwide, resulting in approximately sixty thousand annual hospitalizations of <5-year-olds in the United States alone and three million annual…
Immune checkpoint therapy is one of the most promising immunotherapeutic methods that are likely able to give rise to durable treatment response for various cancer types. Despite much progress in the past decade, there are still critical…