其他定量生物学
The hardware for data archiving has expanded capacities for digital storage enormously in the past decade or more. This article charts the efforts of IUCr to facilitate discussions and plans relating to raw data archiving and reuse within…
Precision medicine aims to create biomedical solutions tailored to specific factors that affect disease risk and treatment responses within the population. The success of the genomics era and recent widespread availability of electronic…
Budding and grafting are the strategies employed to combat unfavorable environmental conditions and improve some physiological defects in the Pistacia vera tree. Drought and salinity stresses are the most prominent adverse conditions…
Medical digital twins are computational models of human biology relevant to a given medical condition, which can be tailored to an individual patient, thereby predicting the course of disease and individualized treatments, an important goal…
Multimodal neuroimaging grants a powerful in vivo window into the structure and function of the human brain. Recent methodological and conceptual advances have enabled investigations of the interplay between large-scale spatial trends, or…
The term bacteriophage means killer or eater of bacteria. They were initially discovered by F.W. Twort and later on, Felix d'Herelle unveiled them to the world in 1910. Phage therapy has arisen as a favorable option to conventional…
Golden Gate cloning has become a powerful and widely used DNA assembly method. Its modular nature and the reusability of standardized parts allow rapid construction of transcription units and multi-gene constructs. Importantly, its modular…
Background and Objectives: We aim to establish deep learning models to optimize the individualized energy delivery for septic patients. Methods and Study Design: We conducted a study of adult septic patients in Intensive Care Unit (ICU),…
Complexity in biology is often described using a multi-map architecture, where the genotype, representing the encoded information, is mapped to the functional level, known as the phenotype, which is then connected to a latent phenotype we…
Although many people believe their pain fluctuates with weather conditions, both weather and pain may be associated with time spent outside. For example, pleasant weather may mean that people spend more time outside doing physical activity…
Seaweeds are well known to concentrate metals from seawater and have been employed as monitors of metal pollution in coastal waters and estuaries. However, research showing that various intrinsic and extrinsic factors can influence metal…
In this study, 529 variables extracted from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of 922 breast cancer patients have been evaluated, focusing on distinguishing between recurrent and non-recurrent cases, as well as…
Computational biology continues to spread into new fields, becoming more accessible to researchers trained in the wet lab who are eager to take advantage of growing datasets, falling costs, and novel assays that present new opportunities…
Computer programming is a fundamental tool for life scientists, allowing them to carry out many essential research tasks. However, despite a variety of educational efforts, learning to write code can be a challenging endeavor for both…
Analyzing the codon usage frequencies of a specimen of 20 plants, for which the codon-anticodon pattern is known, we have remarked that the hierarchy of the usage frequencies present an almost "universal" behavior. Searching to explain this…
Using longitudinal study data, we dynamically model how aging affects homeostasis in both mice and humans. We operationalize homeostasis as a multivariate mean-reverting stochastic process. We hypothesize that biomarkers have stable…
In the case of polymer medical devices, the surface design plays a crucial role in contact with human tissue. The use of AgNPs as antibacterial agents is well known; however, their anchoring into the polymer surface can still be…
The past decade has witnessed a dramatically growing interest in collective intelligence - the phenomenon of groups having an ability to make more accurate decisions than isolated individuals. However, the vast majority of studies to date…
Human behavior training in improvisational theater has shown extensive behavioral and health benefits. Improved empathy measures in medical students, improved behavior outcome in patients with autism and a reduced recidivism rate are among…
This study explores how the COVID-19 pandemic's economic impact has exacerbated nutritional health disparities among women. It sought to understand the effects of economic challenges on women's dietary choices and access to nutritious food…