医学物理

Four-dimensional (4D) wide coverage computed tomography (CT) is an effective imaging modality for measuring the mechanical function of the myocardium. However, repeated CT measurement across several heartbeats is still a concern. A…

Targeted Alpha Therapy (TAT) has emerged as a promising modality for the treatment of various malignancies, leveraging the high linear energy transfer (LET) and short range of alpha particles to selectively irradiate cancer cells while…

Introduction. Noisy measurements frequently cause noisy and inaccurate images in impedance imaging. No post-processing technique exists to calculate the propagation of measurement noise and use this to suppress noise in the image.…

Ultra-high field MRI offers unprecedented detail for non-invasive visualization of the human brain. However, brain imaging is challenging at 7T due to the B$_1^+$ field inhomogeneity, which results in signal intensity drops in temporal…

Diffusion magnetic resonance imaging offers unique in vivo sensitivity to tissue microstructure in brain white matter, which undergoes significant changes during development and is compromised in virtually every neurological disorder. Yet,…

Background, For the purpose of determining the appropriate course of therapy to maintain fertility, a correct diagnosis of ovarian cysts is crucial. Objective, To contrast the results of magnetic resonance imaging and ultrasonography in…

Xerostomia and radiation-induced salivary gland dysfunction remain a common side effect for head-and-neck radiotherapy patients, and attempts have been made to quantify the heterogeneous dose response within parotid glands. Here several…

FLASH Radiotherapy (RT) is a potentially new cancer radiotherapy technique where an entire therapeutic dose is delivered in about 0.1 s and at ~1000 times higher dose rate than in conventional RT. For clinical trials to be conducted safely,…

Cardiovascular diseases (CVDs) and congenital heart diseases (CHD) pose significant global health challenges. Fluoroscopy-guided endovascular interventions, though effective, are accompanied by ionizing radiation concerns, especially in…

Microwave ablation is a therapeutic procedure to eliminate abnormal tissue within a body selectively. There are two types of ablations; the thermal one aims to raise the temperature at the target, while the non-thermal one induces a…

This report relates to a study group hosted by the EPSRC funded network, Integrating data-driven BIOphysical models into REspiratory MEdicine (BIOREME), and supported by The Insigneo Institute and The Knowledge Transfer Network. The BIOREME…

The use of contrast agents has previously been proposed as a novel method to increase the activation close to the Bragg peak, aiming to improve the quality of proton range monitoring in vivo. In a recent work, we demonstrated the…

This work explores the enhancement of ionization clusters around a gold nanoparticle (NP), indicative of the induction of DNA lesions, a potential trigger for cell-death. Monte Carlo track structure simulations were performed to determine…

PULSAR (personalized, ultra-fractionated stereotactic adaptive radiotherapy) is the adaptation of stereotactic ablative radiotherapy towards personalized cancer management. For the first time, we applied a transformer-based attention…

Cardiovascular diseases are the leading cause of death and disability in the world and thus their detection is extremely important as early as possible so that it can be prognosed and managed appropriately. Hence, electrophysiological…

Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) represent versatile tools with diverse applications spanning physics, chemistry, geology, and medical science. This comprehensive review explores the foundational…

Background: Scintillation dosimetry has promising qualities for ultra-high dose rate (UHDR) radiotherapy (RT), but no system has shown compatibility with mean dose rates ($\bar{DR}$) above 100 Gy/s and doses per pulse ($D_p$) exceeding 1.5…

Magnetic susceptibility imaging may provide valuable information about chemical composition and microstructural organization of tissue. However, its estimation from the MRI signal phase is particularly difficult as it is sensitive to…

Magnetic Resonance Imaging (MRI) has become a popular modality in guiding minimally invasive thermal therapies, due to its advanced, non-ionizing, imaging capabilities and its ability to record changes in temperature. A variety of MR…

This study aims to evaluate the functional status of bilateral neurovascular bundles (NVBs) using pulsed wave Doppler ultrasound in patients undergoing prostate radiotherapy (RT). Sixty-two patients (mean age: 66.1 +/- 7.2 years) underwent…