医学物理
Objective: Image reconstruction in high resolution PET scanners with depth of interaction (DOI) capability is computationally challenging due to the high sampling in detector and image space. This study evaluates the use of a virtual…
Radiometric surveys in radiotherapy bunkers have been carried out in Brazil for many years, both by the same radiotherapy facility for verification of shielding as by the regulatory agency for licensing and control purposes. In recent…
Purpose: Current 3D Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) protocols use transient-state, gradient-spoiled gradient-echo sequences that are prone to cerebrospinal fluid (CSF) pulsation artifacts when applied to the…
The present study introduces an advanced multi-physics and multi-scale modeling approach to investigate in silico colon motility. We introduce a generalized electromechanical framework, integrating cellular electrophysiology and smooth…
Positron Emission Tomography (PET) is a crucial tool in medical imaging, particularly for diagnosing diseases like cancer and Alzheimer's. The advent of Positronium Lifetime Imaging (PLI) has opened new avenues for assessing the tissue…
Significance: Photoacoustic imaging (PAI) promises to measure spatially-resolved blood oxygen saturation, but suffers from a lack of accurate and robust spectral unmixing methods to deliver on this promise. Accurate blood oxygenation…
Electroporation (EP), the temporary or permanent permeabilization of the cell membrane induced by an electric field, is the basis of various applications in medicine and food processing. In EP-based protocol optimization in terms of pulse…
Particle therapy is a well established clinical treatment of tumors. More than one hundred particle therapy centers are in operation world wide. The advantage of using hadrons like protons or carbon ions as particles for tumor irradiation…
Purpose: To develop an efficient navigator-based motion and temporal B0 shift correction technique for 3D multi-echo gradient-echo (ME-GRE) MRI for quantitative susceptibility mapping (QSM) and R2* mapping. Theory and Methods: A dual-echo…
Magnetoencephalography (MEG) conventionally operates within high-performance magnetic shields due to the extremely weak magnetic field signals from the measured objects and the narrow dynamic range of the magnetic sensors employed for…
Photoacoustic (PA) technology can provide information on both the physical structure and chemical composition of bone, showing great potential in bone assessment. However, due to the complex composition and porous structure of cancellous…
One challenge on the path to delivering FLASH-compatible beams with a synchrotron is facilitating an accurate dose-control for the required ultra-high dose rates. We propose the use of pulsed RFKO extraction instead of continuous beam…
Background: Dual-energy imaging on cone-beam CT (CBCT) scanners has great potential in different clinical applications, including image-guided surgery and adaptive proton therapy. However, the clinical practice of dual-energy CBCT (DE-CBCT)…
In recent years, the use of Monte Carlo (MC) simulations in the domain of Medical Physics has become a state-of-the-art technology that consumes lots of computational resources for the accurate prediction of particle interactions. The use…
Background and Objective: Data from electro-anatomical mapping (EAM) systems are playing an increasingly important role in computational modeling studies for the patient-specific calibration of digital twin models. However, data exported…
When the early stopping parameter n.earlystop is relatively small or the cohortsize value is not optimized via simulation, it may be better to use p.tox < 1.4 * target.DLT.rate, or try out different cohort sizes, or increase n.earlystop,…
Using recent advances in generative artificial intelligence (AI) brought by diffusion models, this paper introduces a new synergistic method for spectral computed tomography (CT) reconstruction. Diffusion models define a neural network to…
A comprehensive assessment of retinal health demands reliable and precise methods to measure localized blood perfusion. Despite considerable advancements in imaging techniques, such as indocyanine green and fluorescein angiography, along…
We present the first fully two-dimensional attenuation imaging technique developed for pulse-echo ultrasound systems. Unlike state-of-the-art techniques, which use line-by-line acquisitions, our method uses steered emissions to constrain…
This paper characterizes the microdosimetric spectra of a single-energy carbon-ion pencil beam at MedAustron using a miniature solid-state silicon microdosimeter to estimate the impact of the lateral distribution of the different fragments…