医学物理
Purpose: To develop a 3D distortion-free reduced-FOV diffusion-prepared GRE sequence and demonstrate its in-vivo application for diffusion imaging of the spinal cord in healthy volunteers. Methods: A 3D multi-shot reduced-FOV…
Purpose: From the myofibrils to the whole muscle scale, muscle micro-constituents exhibit passive and active mechanical properties, potentially coupled to electrical, chemical, and thermal properties. Experimental characterization of some…
Optical imaging of blood flow yields critical functional insights into the circulatory system, but its clinical implementation has typically been limited to shallow depths (~1 millimeter) due to light scattering in biological tissue. Here,…
Today's mechanical tools for bone cutting (osteotomy) cause mechanical trauma that prolongs the healing process. Medical device manufacturers aim to minimize this trauma, with minimally invasive surgery using laser cutting as one…
With a high rate of morbidity and mortality, colorectal cancer (CRC) ranks third in mortality among cancers. By analyzing the texture properties of images and quantifying the heterogeneity of tumors, radiomics and radiogenomics are…
This paper proposes a novel approach to spectral computed tomography (CT) material decomposition that uses the recent advances in generative diffusion models (DMs) for inverse problems. Spectral CT and more particularly photon-counting CT…
Advances in three-dimensional imaging provide the ability to construct and analyze finite element (FE) models to evaluate the biomechanical behavior and function of atrioventricular valves. However, while obtaining patient-specific valve…
Background: Cone-beam computed tomography (CBCT) scans, performed fractionally (e.g., daily or weekly), are widely utilized for patient alignment in the image-guided radiotherapy (IGRT) process, thereby making it a potential imaging…
3D-localization of gamma sources has the potential to improve the outcome of radio-guided surgery. The goal of this paper is to analyze the localization accuracy for point-like sources with a single coded aperture camera. We both simulated…
As a biomarker for liver disease, bilirubin has been utilized in prognostic scoring systems for cirrhosis. While laboratory-based methods are used to determine bilirubin levels in clinical settings, they do not readily lend themselves to…
Background The incidence of stroke places a heavy burden on both society and individuals. Activity is closely related to cardiovascular health. This study aimed to investigate the relationship between the varying domains of PA, like…
Small Angle-X-ray Scattering Tensor Tomography (SAS-TT) is a relatively new, but powerful technique for studying the multiscale architecture of hierarchical structures, which is of particular interest for life science applications.…
Therapeutic ultrasound for brain stimulation has increased in the last years. This energy has shown promising results for treating Alzheimers disease, Parkinsons disease, and traumatic brain injury, among other conditions. However, the…
We propose a suite of technologies for analyzing the interaction between anisotropic arterial walls and blood flow for subject-specific geometries. Utilizing an established lumen modeling strategy, we present a comprehensive pipeline for…
Objective: The transmit encoding model for synthetic aperture imaging is a robust and flexible framework for understanding the effects of acoustic transmission on ultrasound image reconstruction. Our objective is to use machine learning…
The rapid spread of SARS-CoV-2 caused the COVID-19 pandemic and accelerated vaccine development to prevent the spread of the virus and control the disease. Given the sustained high infectivity and evolution of SARS-CoV-2, there is an…
Combining dual-energy computed tomography (DECT) with positron emission tomography (PET) offers many potential clinical applications but typically requires expensive hardware upgrades or increases radiation doses on PET/CT scanners due to…
We demonstrate the use of a phase retrieval technique for propagation-based phase contrast neutron imaging with a polychromatic beam. This enables imaging samples with low absorption contrast and/or improving the signal-to-noise ratio to…
Quantitative analysis of cell structures is essential for biomedical and pharmaceutical research. The standard imaging approach relies on fluorescence microscopy, where cell structures of interest are labeled by chemical staining…
A renewed interest in upright therapy is currently driven by the availability of upright positioning and imaging systems. Aside from reduced cost, upright positioning possibly provides clinical advantages. The comparison between upright and…