医学物理
Diffusion Posterior Sampling (DPS) can be used in Computed Tomography (CT) reconstruction by leveraging diffusion-based generative models for unconditional image synthesis while matching the observations (data) of a CT scan. Of particular…
Objective. The availability of magnetic nanoparticles with medical approval for human intervention is fundamental to the clinical translation of magnetic particle imaging (MPI). In this work, we thoroughly evaluate and compare the magnetic…
In MR fingerprinting (MRF) reconstruction, measured data is pattern-matched to simulated signals to extract quantitative tissue parameters. A critical drawback to this approach is the exponentially increasing compute time for mapping of…
$\textbf{Purpose}$: To develop a clinical CEST MR fingerprinting (CEST-MRF) method for brain tumor quantification using EPI acquisition and deep learning reconstruction. $\textbf{Methods}$: A CEST-MRF pulse sequence originally designed for…
Purpose: To develop a fast magnetic resonance fingerprinting (MRF) method for quantitative chemical exchange saturation transfer (CEST) imaging. Methods: We implemented a CEST-MRF method to quantify the chemical exchange rate and volume…
Purpose: Proton MR spectroscopic imaging (1H MRSI) without water suppression (WS) possess some distinct advantages over the conventionally used 1H MRSI with WS. However, the sideband artifacts in the non-water suppressed spectra hinder the…
Field-Effect Transistors with graphene channels or GFETs are an interesting alternative for the detection of analytes in biological fluids since the electrical behavior of the channel changes when exposed to a sample (among other detection…
Ion computed tomography (iCT) is an imaging modality for the direct determination of the relative stopping power (RSP) distribution within a patient's body. Usually, this is done by estimating the path and energy loss of ions traversing the…
Ultrasound Localization Microscopy (ULM) relies on the injection of microbubbles (MBs) to obtain highly resolved density maps of blood circulation in vivo, with a resolution that can reach 10 {\mu}m ~ {\lambda}/10 in the rodent brain.…
Combined extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT) pose complex hemodynamic challenges in intensive care. In this study, a comprehensive lumped parameter model (LPM) is developed to simulate…
Evidence is accumulating in favour of using stereotactic ablative body radiotherapy (SABR) to treat multiple cancer lesions in the lung. Multi-lesion lung SABR plans are complex and require significant resources to create. In this work, we…
Electronic textiles (E-textiles) offer great wearing comfort and unobtrusiveness, thus holding potential for next-generation health monitoring wearables. However, the practical implementation is hampered by challenges associated with poor…
The brain's microvascular cerebral capillary network plays a vital role in maintaining neuronal health, yet capillary dynamics are still not well understood due to limitations in existing imaging techniques. Here, we present Single…
Tumor Treating Fields (TTFields) is a non-invasive anticancer modality that utilizes alternating electric fields to disrupt cancer cell division and growth. While generally well-tolerated with minimal side effects, traditional TTFields…
Radiation therapy (RT) is one of the most effective treatments for cancer, and its success relies on the accurate delineation of targets. However, target delineation is a comprehensive medical decision that currently relies purely on manual…
Background: Experiments have reported low normal tissue toxicities during FLASH radiation, but the mechanism has not been elaborated. Several hypotheses have been proposed to explain the mechanism. The oxygen depletion hypothesis has been…
Aims: The presence of coronary tandem lesions poses a significant challenge for the accurate diagnosis and management of coronary artery diseases. This study set out to provide a deeper understanding of the haemodynamic interactions between…
Broadband NIRS (bNIRS) is an extension of fNIRS that provides the same assessment of oxygenation biomarkers along with a valuable marker for oxygen metabolism at a cellular level, the oxidation state of cytochrome-c-oxidase (oxCCO). bNIRS…
Purpose: To harmonize the use of color for MR relaxometry maps and therefore recommend the use of specific color-maps for representing T1 and T2 maps. Methods: Perceptually linearized color-maps were chosen to have similar color settings as…
The importance of computers is continually increasing in radiotherapy. Efficient algorithms, implementations and the ability to leverage advancements in computer science are crucial to improve cancer care even further and deliver the best…