医学物理
In MRI-guided laser interstitial thermotherapy (MRgLITT), a signal void sometimes appears at the heating center of the measured temperature map. In neurosurgical MRgLITT treatments, cerebrospinal fluid pulsation (CSF), which may lead to…
Purpose: Our aim was to elucidate the critical factors responsible for inducing the FLASH effect, focusing on the role of free radicals through simulation and experimental approaches. Methods and Materials: The whole abdomen of C57BL/6 mice…
Deep learning-based automated contouring and treatment planning has been proven to improve the efficiency and accuracy of radiotherapy. However, conventional radiotherapy treatment planning process has the automated contouring and treatment…
Magnetic resonance (MR)-guided radiation therapy (RT) is enhancing head and neck cancer (HNC) treatment through superior soft tissue contrast and longitudinal imaging capabilities. However, manual tumor segmentation remains a significant…
Audiological datasets contain valuable knowledge about hearing loss in patients, which can be uncovered using data-driven, federated learning techniques. Our previous approach summarized patient information from one audiological dataset…
Background: Intensity-modulated proton therapy (IMPT) using pencil beam technique scans tumor in a layer by layer, then spot by spot manner. It can provide highly conformal dose to tumor targets and spare nearby organs-at-risk (OAR). Fast…
Objective: Proton spot-scanning arc therapy (ARC) is an emerging modality that can improve the high-dose conformity to targets compared with standard intensity-modulated proton therapy (IMPT). However, the efficient treatment delivery of…
Purpose: Deformable image registration (DIR) is critical in adaptive radiation therapy (ART) to account for anatomical changes. Conventional intensity-based DIR methods often fail when image intensities differ. This study evaluates a hybrid…
In this work, we present a fundamental mathematical model for proton transport, tailored to capture the key physical processes underpinning Proton Beam Therapy (PBT). The model provides a robust and computationally efficient framework for…
Purpose: ECG and respiratory-gated preclinical cardiac CEST-MRI acquisitions are difficult due to variable saturation recovery with T1, RF interference in the ECG signal, and offset-to-offset variation in Z-magnetization and cardiac phase…
Abdominal electrocardiogram (AECG) gives a safe and non-invasive way to monitor fetal well-being during pregnancy using surface electrodes. However, it is challenging to extract weak fetal ECG (fECG) from the AECG recordings with larger…
In lung radiotherapy, the primary objective is to optimize treatment outcomes by minimizing exposure to healthy tissues while delivering the prescribed dose to the target volume. The challenge lies in accounting for lung tissue motion due…
The steep dose gradients obtained with pencil beam scanning allow for precise tumor targeting at the cost of high sensitivity to uncertainties. Robust optimization is commonly applied to mitigate uncertainties in density and patient setup,…
Inhalers with corticosteroids and muscle relaxants are prescribed by pulmonologists to mitigate bronchospasms that happen due to tightening of the chest. An adhesive patch attached to a patient with chronic obstructive pulmonary disease can…
Objective: Shoulder exoskeletons can effectively assist with overhead work. However, their impacts on muscle synergy remain unclear. The objective is to systematically investigate the effects of the shoulder exoskeleton on muscle synergies…
Stereotactic Body Radiation Therapy (SBRT) can be a precise, minimally invasive treatment method for liver cancer and liver metastases. However, the effectiveness of SBRT relies on the accurate delivery of the dose to the tumor while…
Mechanical stress-induced damage to the articular cartilage can result in fracture imitation or significant tissue degeneration leading to osteoarthritis (OA) compromising joint mobility. Despite the clinical significance, a comprehensive…
The Rytov approximation has been commonly used to obtain reconstructed images for optical tomography. However, the method requires linearization of the nonlinear inverse problem. Here, we demonstrate nonlinear Rytov approximations by…
3D multi-slab acquisitions are an appealing approach for diffusion MRI because they are compatible with the imaging regime delivering optimal SNR efficiency. In conventional 3D multi-slab imaging, shot-to-shot phase variations caused by…
4D CT imaging is an essential component of radiotherapy of thoracic/abdominal tumors. 4D CT images are, however, often affected by artifacts that compromise treatment planning quality. In this work, deep learning (DL)-based conditional…