医学物理
Nanomedicine research started exploring the combination of therapy and diagnostics, so-called theranostics, to offer a more flexible care with improved outcome. As magnetic nanoparticles show great potential in many diagnostic and…
Lifting up objects from the floor has been identified as a risk factor for low back pain, whereby a flexed spine during lifting is often associated with producing higher loads in the lumbar spine. Even though recent biomechanical studies…
The widely held belief that squat lifting should be preferred over stoop lifting to prevent back injury is increasingly being challenged by recent biomechanical evidence. However, most of these studies only focus on very localized…
Radiotherapy inverse planning often requires planners to modify parameters in the treatment planning system's objective function to produce clinically acceptable plans. Due to the manual steps in this process, plan quality can vary…
Musculoskeletal models have the potential to improve diagnosis and optimize clinical treatment by predicting accurate outcomes on an individual basis. However, the subject-specific modeling of spinal alignment is often strongly simplified…
We present a microscopic mechanism that accounts for the outward burst of "cold" ion species (IS) in a high-energy particle track due to coupling with ''hot" non-ion species (NIS). IS refers to radiolysis products of ionized molecules,…
Spectroscopic x-ray detectors (SXDs) are poised to play a substantial role in the next generation of medical x-ray imaging. Evaluating their performance in terms of the detective quantum efficiency (DQE) requires normalization of the…
Deep learning has a great potential for estimating biomarkers in diffusion weighted magnetic resonance imaging (dMRI). Atlases, on the other hand, are a unique tool for modeling the spatio-temporal variability of biomarkers. In this paper,…
MR-STAT is an emerging quantitative magnetic resonance imaging technique which aims at obtaining multi-parametric tissue parameter maps from single short scans. It describes the relationship between the spatial-domain tissue parameters and…
Novel radiotherapy techniques like synchrotron X-ray microbeam radiation therapy (MRT), require fast dose distribution predictions that are accurate at the sub-mm level, especially close to tissue/bone/air interfaces. Monte Carlo physics…
In addition to topical delivery, nasal sprays offer an alternative drug administration route to the systemic circulation, therefore avoiding the need for painful, invasive delivery techniques. Studies on the efficacy of nasal drug delivery…
Magnetic Particle Imaging (MPI) is a tomographic imaging technique for determining the spatial distribution of superparamagnetic nanoparticles. Current MPI systems are capable of imaging iron masses over a wide dynamic range of more than…
Major topics in medical ultrasound rest on the physics of wave propagation through tissue. These include fundamental treatments of backscatter, speed of sound, attenuation, and speckle formation. Each topic has developed its own rich…
The generalized minimal residual (GMRES) algorithm is applied to image reconstruction using linear computed tomography (CT) models. The GMRES algorithm iteratively solves square, non-symmetric linear systems and it has practical application…
Proton therapy is a cancer treatment technique currently in growth worldwide. It offers advantages with respect to conventional X-ray and $\gamma$-ray radiotherapy, in particular, a better control of the dose deposition allowing to reach a…
Purpose: As a typical chronic kidney disease (CKD), hypertensive nephrosclerosis (HN) is a common syndrome of hypertension, characterized by chronic kidney microvascular damage. Early diagnosis of microvascular damage using conventional…
Magnetic particle imaging is a tracer based imaging technique to determine the spatial distribution of superparamagnetic iron oxide nanoparticles with a high spatial and temporal resolution. Due to physiological constraints, the imaging…
The tomographic imaging method magnetic particle imaging (MPI) requires a multi-patch approach for capturing large field of views. This approach consists of a continuous or stepwise spatial shift of a small sub-volume of only few cubic…
Purpose: To improve upon Extreme MRI, a recently proposed method by Ong Et al. for reconstructing high spatiotemporal resolution, 3D non-Cartesian acquisitions by incorporating motion compensation into these reconstructions using an…
Sunscreen lotions are used to protect the skin from damage due to solar ultraviolet (UV) radiation. The active UV blocking components can be organic molecules or inorganic particles, for example TiO2. While both in vivo and in vitro methods…