医学物理
Photoacoustic computed tomography (PACT) is a hybrid imaging modality, which combines the high optical contrast of pure optical imaging and the high penetration depth of ultrasound imaging. However, photoacoustic image dataset with good…
It has been recently demonstrated that use of ultrasound increases the tissue yield in ultrasound-enhanced fine-needle aspiration biopsy (USeFNAB) as compared to conventional fine-needle aspiration biopsy (FNAB). To date, the association…
Attenuation coefficient (AC) is a fundamental measure of tissue acoustical properties, which can be used in medical diagnostics. In this work, we investigate the feasibility of using convolutional neural networks (CNNs) to directly estimate…
Accurate MR-based attenuation correction (MRAC) is essential for quantitative PET/MR imaging of the brain. In this study, we analyze the regional bias caused by MRAC based on Zero-Echo-Time MR images (ZTEAC) compared to CT-based AC (CTAC)…
Surgical simulators have been widely used in training and evaluation of physicians and surgeons. Virtual reality augmented with haptic technology has made it feasible to develop more realistic surgical simulators. In this context, we set…
Flexible and epidermal sensing devices are becoming vital to enable precision medicine and telemonitoring systems. The NFC (Near Field Communication) protocol is also becoming increasingly important for this application since it is embedded…
In this paper we present KiT-RT (Kinetic Transport Solver for Radiation Therapy), an open-source C++ based framework for solving kinetic equations in radiation therapy applications. The aim of this code framework is to provide a collection…
Proton therapy is a modality in fast development. Characterized by a maximum dose deposition at the end of the proton trajectory followed by a sharp fall-off, proton beams can deliver a highly conformal dose to the tumor while sparing…
The dose delivered to the planning target volume by proton beams is highly conformal, sparing organs at risk and normal tissues. New treatment planning systems adapted to spot scanning techniques have been recently proposed to…
Non-invasive in vivo sensing of the lung with light would help diagnose and monitor pulmonary disorders (caused by e.g. COVID-19, emphysema, immature lung tissue in infants). We investigated the possibility to probe the lung with time…
It has been postulated that the delivery of radiotherapy at ultra-high dose rates ("FLASH") reduces normal tissue toxicities by depleting them of oxygen. The fraction of normal tissue and cancer cells surviving radiotherapy depends on dose…
Synthetic transmit aperture (STA) ultrasound imaging is well known for ideal focusing in the full field of view. However, it suffers from low signal-to-noise ratio (SNR) and low frame rate, because each array element must be activated…
Diffusion-weighted imaging (DWI) is a powerful non-invasive tool which is widely used in clinical routine. Mostly, apparent diffusion coefficient maps are acquired, which cannot be directly related to cellular structure. More recently it…
Synthetic transmit aperture (STA) imaging can achieve optimal lateral resolution in the full field of view, at the cost of low frame rate (FR) and low signal-to-noise ratio (SNR). In our previous studies, compressed sensing based synthetic…
Purpose: To describe the dosimetric commissioning and quality assurance (QA) of the actively scanned proton and carbon ion beams at the Italian National Center for Oncological Hadrontherapy. Methods: The laterally integrated…
The widespread diffusion of precision radiotherapy techniques, geared toward the release of larger dose gradients in shorter time frames, is leading to new challenges in dosimetry. Accurate dose measurements are essential to check for beam…
We present an optimization-based approach to radiation treatment planning over time. Our approach formulates treatment planning as an optimal control problem with nonlinear patient health dynamics derived from the standard linear-quadratic…
Willem Einthoven is widely considered the father of the electrocardiogram (ECG). In 1912, he proposed a method of determining the electric axis of the heart by using an imaginary equilateral triangle connecting the limb leads, now known as…
Activities such as singing or playing a wind instrument release respiratory particles into the air that may contain pathogens and thus pose a risk for infection transmission. Here we report measurements of the size distribution, number, and…
Single-photon emission computed tomography (SPECT) provides a mechanism to estimate regional isotope uptake in lesions and at-risk organs after administration of {\alpha}-particle-emitting radiopharmaceutical therapies ({\alpha}-RPTs).…