生物物理
The dynamics of cellular pattern formation is crucial for understanding embryonic development and tissue morphogenesis. Recent studies have shown that human dermal fibroblasts cultured on liquid crystal elastomers can exhibit an increase in…
In this work, we develop model for neuronal degeneration based on polymer chain folding dynamics and their connectivity in various scale. In the first phase, we just developed the model and numerical simulation need to be complete in order…
Multicellular cable bacteria display an exceptional form of biological conduction, channeling electrical currents across centimeter distances through a regular network of protein fibers embedded in the cell envelope. The fiber conductivity…
The smallest flying insects often have bristled wings resembling feathers or combs. We combined experiments and three-dimensional numerical simulations to investigate the trade-off between wing weight and drag generation. In experiments of…
We study symmetries in the phase plane for separable, autonomous two-state systems of ordinary differential equations (ODEs). We prove two main theoretical results concerning the existence and non-triviality of two orthogonal symmetries for…
Inspired by massive intermediate filament (IF) reorganization in superstretched epithelia, we examine computationally the principles controlling the mechanics of a set of entangled filaments whose ends slide on the cell boundary. We…
Protons in the gap between base pairs of the double helix store the code of life by breaking the chiral symmetry that swaps the sense strand with its complementary partner. When these hydrogen bonds break during replication and…
One of the primary computational requirements of a cellular system is the ability to transfer information between spatially separated components. To accomplish this, biology uses diverse physical channels including production or release of…
Cell crawling crucially depends on the collective dynamics of the acto-myosin cytoskeleton. However, it remains an open question to what extent cell polarization and persistent motion depend on continuous regulatory mechanisms and…
A continuum description is built to characterize the stationary and transient deformations of confluent tissues subject to heterogeneous activities. By defining a coarse-grained texture matrix field to represent the shape and size of cells,…
Known physical mechanisms of temperature dependence anomalies of water properties were used to explain the regularities in temperature dependence (TDs) of dynamic, electrical and optical characteristics of biological systems. The dynamics…
Centrifuges serve as essential instruments in modern experimental sciences, facilitating a wide range of routine sample processing tasks that necessitate material sedimentation. However, the study for real time observation of the dynamical…
We present a field theory to describe the composition of a surface spontaneously exchanging matter with its bulk environment. By only assuming matter conservation in the system, we show with extensive numerical simulations that, depending…
Spiral waves are ubiquitous spatiotemporal patterns that occur in various excitable systems. In cardiac tissue, the formation of these spiral waves is associated with life-threatening arrhythmias, and, therefore, it is important to study…
Introducing environmental feedback into evolutionary game theory has led to the development of eco-evolutionary games, which have gained popularity due to their ability to capture the intricate interplay between the environment and…
The Starling principle describes exchanges in tissues based on the balance of hydrostatic and osmotic flows. This balance neglects the coupling between mechanics and hydrodynamics, a questionable assumption in strained elastic tissues due…
Intracellular transport of cargoes in the cell is essential for the organization and functioning cells, especially those that are large and elongated. The cytoskeletal networks inside large cells can be highly complex, and this cytoskeletal…
We present a tutorial on setting-up the oxDNA coarse-grained model for simulations of DNA and RNA nanotechnology. The model is a popular tool used both by theorists and experimentalists to simulate nucleic acid systems both in biology and…
In this article, I present a novel and computational-efficient approach for treatment-response modeling of tumor progression-free survival (PFS) probability using the physical phenomenon of a quantum particle walking on a one-dimensional…
We utilize whole-body Hydra regeneration from a small tissue segment to develop a physics framework for animal morphogenesis. Introducing experimental controls over this process, an external electric field and a drug that blocks gap…