生物物理
Currently, the world has been facing the brunt of a pandemic due to a disease called COVID-19 for the last 2 years. To study the spread of such infectious diseases it is important to not only understand their temporal evolution but also the…
Diabetes mellitus is a disease which is currently a huge health hazard globally. The cases of diabetes had increased by a significant amount in past decades. Also it has been predicted that it will further increase in future. Diabetes…
Small extracellular vesicles (sEVs) are known to play an important role in the communication between distant cells and to deliver biological information throughout the body. To date, many studies have focused on the role of sEVs…
This paper presents a novel approach for predicting the relative populations of protein conformations using AlphaFold 2, an AI-powered method that has revolutionized biology by enabling the accurate prediction of protein structures. While…
The glassy cytoplasm, crowded with bio-macromolecules, is fluidized in living cells by mechanical energy derived from metabolism. Characterizing the living cytoplasm as a non-equilibrium system is crucial in elucidating the intricate…
Epithelial morphogenesis, a signature problem of tissue biology and tissue mechanics, continues to inspire biologists and physicists alike. Many treatments focus on tissue fluidization, apical/basal ratio changes, or mechanical…
This paper proposes a novel self-supervised learning method, RELAX-MORE, for quantitative MRI (qMRI) reconstruction. The proposed method uses an optimization algorithm to unroll a model-based qMRI reconstruction into a deep learning…
In vivo, cells navigate through complex environments filled with obstacles. Recently, the term 'topotaxis' has been introduced for navigation along topographic cues such as obstacle density gradients. Experimental and mathematical efforts…
Strongly opinionated minorities can have a dramatic impact on the opinion dynamics of a large population. Two factions of inflexible minorities, polarised into two competing opinions, could lead the entire population to persistent…
The physics of active biological matter, such as bacterial colonies and bird flocks, exhibiting interesting self-organizing dynamical behavior has gained considerable importance in recent years. Recent theoretical advances use techniques…
The present study investigated the effect of a passive lower-limb exoskeleton on lumbar load and verified the effectiveness of biomechanical analysis for evaluating the physical burden while wearing the exoskeleton. Twelve healthy male…
In many organisms, cell division is driven by the constriction of a cytokinetic ring, which consists of actin filaments and crosslinking proteins. While it has long been believed that the constriction is driven by motor proteins, it has…
Many fundamental biological processes are dependent on cellular migration. Although the mechanical mechanisms of single-cell migration are relatively well understood, those underlying migration of multiple cells adhered to each other in a…
Dynabeads are superparamagnetic particles used for immunomagnetic purification of cells and biomolecules. Post-capture, however, target identification relies on tedious culturing, fluorescence staining and/or target amplification. Raman…
Hydra tissue fragments excised freshly from Hydra body bend spontaneously to some quasi-stable shape in several minutes. We propose that the spontaneous bending is driven mechanically by supracellular actomyosin bundles inherited from…
Eukaryotic cells can polarize and migrate in response to electric fields via "galvanotaxis," which aids wound healing. Experimental evidence suggests cells sense electric fields via molecules on the cell's surface redistributing via…
The development of multi-drug-resistant bacterial infections seriously threatens public health, so efforts are needed to develop a new class of safe and effective antibacterial agents. Here, we report a bio-inspired synthesis of…
Large interacting systems in biology often exhibit emergent dynamics, such as coexistence of multiple time scales, manifested by fat tails in the distribution of waiting times. While existing tools in statistical inference, such as maximum…
The Extra-Cellular-Matrix (ECM) is a complex interconnected 3D network that provides structural support for the cells and tissues and defines organ architecture key for their healthy functioning. However, the intimate mechanisms by which…
Sperm modulate their flagellar symmetry to navigate through complex physico-chemical environments and achieve reproductive function. Yet it remains elusive how sperm swim forwards despite the inherent asymmetry of several components that…