生物物理
Hydrogen bond networks play vital roles in biological functions ranging from protein folding to enzyme catalysis. Here we combine electronic structure calculations and ab initio path integral molecular dynamics simulations, which…
We use a three-bead-spring model to investigate the dynamics of bi-flagellate micro-swimmers near a surface. While the primary dynamics and scattering are governed by geometric-dependent direct contact, the fluid flows generated by the…
The present paper deals with an experimental feasibility study concerning the detection of long- range intermolecular interactions through molecular diffusion behavior in solution. This follows previous analyses, theoretical and numerical,…
Many spherical viruses encapsulate their genome in protein shells with icosahedral symmetry. This process is spontaneous and driven by electrostatic interactions between positive domains on the virus coat proteins and the negative genome.…
A trophallaxis inspired model for distributed transport between randomly interacting agents Trophallaxis, the regurgitation and mouth to mouth transfer of liquid food between members of eusocial insect societies, is an important process…
A variety of numerical methods exist for the study of deformable particles in dense suspensions. None of the standard tools, however, currently include volume-changing objects such as oscillating microbubbles in three-dimensional periodic…
Electrical signals play the primary role in rapid communication among organs, tissues and cells in biosystems. We have analyzed and discussed three phenomena of electrical communication in biosystems, including direction-changing movement…
Under supercoiling constraints, naked DNA, such as a large part of bacterial DNA, folds into braided structures called plectonemes. The double-helix can also undergo local structural transitions, leading to the formation of denaturation…
We present a model of the dynamical transition of atomic displacements in proteins. Increased mean-square displacement at higher temperatures is caused by softening of the vibrational force constant by electrostatic and van der Waals forces…
Suspensions of self-motile, elongated particles are a topic of significant current interest, exemplifying a form of `active matter'. Examples include self-propelling bacteria, algae and sperm, and artificial swimmers. Ericksen's model of a…
Crowded environments modify the diffusion of macromolecules, generally slowing their movement and inducing transient anomalous subdiffusion. The presence of obstacles also modifies the kinetics and equilibrium behavior of tracers. While…
Many cells exploit the bending or rotation of flagellar filaments in order to self-propel in viscous fluids. While appropriate theoretical modelling is available to capture flagella locomotion in simple, Newtonian fluids, formidable…
Recent experiments have revealed that the diffusivity of exothermic and fast enzymes is enhanced when they are catalytically active, and different physical mechanisms have been explored and quantified to account for this observation. We…
The present work reports the formation and the characterization of antipleptic and symplectic metachronal waves in 3D cilia arrays immersed in a two-fluid environment, with a viscosity ratio of 20. A coupled…
The propagation of a beneficial mutation in a spatially extended population is usually studied using the phenomenological stochastic Fisher-Kolmogorov (SFKPP) equation. We derive here an individual based, stochastic model founded on the…
Osteocytes and their cell processes reside in a large, interconnected network of voids pervading the mineralized bone matrix of most vertebrates. This osteocyte lacuno-canalicular network (OLCN) is believed to play important roles in…
Undulatory locomotion, as seen in the nematode \emph{Caenorhabditis elegans}, is a common swimming gait of organisms in the low Reynolds number regime, where viscous forces are dominant. While the nematode's motility is expected to be a…
We studied intermediate filaments (IFs) in the retina of the Pied flycatcher (Ficedula hypoleuca) in the foveolar zone. Single IFs span M\"uller cells (MC) lengthwise; cylindrical bundles of IFs (IFBs) appear inside the cone inner segment…
A boundary value problem, which could represent a transcendent temperature conduction problem with evaporation in a part of the boundary, was studied to determine unknown thermophysical parameters, which can be constants or time dependent…
High-fidelity analysis of translocating biomolecules through nanopores demands shortening the nanocapillary length to a minimal value. Existing nanopores and capillaries, however, inherit a finite length from the parent membranes. Here, we…