基于广义Richardson-Lucy方法的平移式结构照明显微镜

结构照明显微镜（SIM）通过施加 illumination translations相对于 object来实现超过经典衍射极限的 2 倍分辨率提升。该 method还成功实现了一种 ``blind'' configuration，即 with unknown illumination patterns，允许对 illumination delivery更放宽的约束。本文提出了一种 novel super-resolution algorithm，该 algorithm employs a generalized version of the popular Richardson-Lucy algorithm，alongside an optimized and customized optical setup。Both numerical and experimental validations表明，我们的 technique exhibits high noise resilience。Moreover，by implementing random translations instead of ``ordered'' ones，noise-related artifacts被减少。这些 advancements enable wide-field super-resolved imaging with significantly reduced optical complexity。